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Jessica R. Kramer
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Phone: 801-213-2039
Office: 5209 Sorenson Molecular Biotechnology Building (SMBB)

Jessica R. Kramer

National Institute of Health Postdoc, Stanford University
University of California Chancellor's Postdoc, UC Berkeley
Ph.D. Organic Chemistry, UCLA
B.S. Biochemistry, University of Utah

Research

Biomaterials, Cancer Diagnostics & Therapeutics, Glycobiology, Regenerative Medicine, Drug Delivery


Current Research

Glycocalyx engineering and cancer:

The surface of every cell is covered with an array of glycoproteins and glycolipids that collectively form the glycocalyx. Cancer cells have a strikingly altered glycocalyx, but the causes and effects are poorly understood. The Kramer lab is developing tools for precision glycocalyx engineering that enable systematic studies of the surface of cancer cells and at sites of inflammation. This knowledge aids in design of diagnostics, therapeutics, and vaccines for epithelial cancers.

Cryopreservation of tissue and whole organs:

Cells, tissues, and whole organs are essential elements in life-saving regenerative medicine. To slow cellular degradation processes and bacterial growth, tissues must be stored at reduced or sub-zero temperatures. Many therapeutic cells have reduced viability after freeze/thaw procedures, and platelets, and whole organs can't be frozen at all. Tragically, some organs go unused simply because they cannot be transplanted in time. Our lab researches bioinspired materials and methods that address the need for effective, low cost, biocompatible cryopreservation.

Delivery of therapeutics to the CNS:

Clinical use of therapeutic drugs, proteins, and genetic materials is often challenged by selective targeting of diseased tissue while sparing healthy tissue. Treatment of central nervous system (CNS) diseases is particularly difficult since crossing the blood brain barrier remains problematic. The Kramer lab is researching materials and methods that safely and efficiently deliver therapeutics across the blood brain barrier, and to other tissues throughout the human body.


Selected Publications

Kramer JR, Onoa B, Bustamante C, Bertozzi CR, Chemically tunable mucin chimeras assembled on living cells. Proc Natl Acad Sci U S A 2015 Oct 13;112(41):12574-9

Kramer JR, Schmidt NW, Mayle KM, Kamei DT, Wong GC, Deming TJ, Reinventing Cell Penetrating Peptides Using Glycosylated Methionine Sulfonium Ion Sequences. ACS Cent Sci 2015 May 27;1(2):83-8

Kramer JR, Deming TJ, Multimodal switching of conformation and solubility in homocysteine derived polypeptides. J Am Chem Soc 2014 Apr 16;136(15):5547-50

Rodriguez AR, Kramer JR, Deming TJ, Enzyme-triggered cargo release from methionine sulfoxide containing copolypeptide vesicles. Biomacromolecules 2013 Oct 14;14(10):3610-4

Kramer JR, Deming TJ, Reversible chemoselective tagging and functionalization of methionine containing peptides. Chem Commun (Camb) 2013 Jun 7;49(45):5144-6

Kramer JR, Deming TJ, Preparation of multifunctional and multireactive polypeptides via methionine alkylation. Biomacromolecules 2012 Jun 11;13(6):1719-23

Kramer JR, Deming TJ, Glycopolypeptides with a redox-triggered helix-to-coil transition. J Am Chem Soc 2012 Mar 7;134(9):4112-5

Kramer JR, Deming TJ, General method for purification of a-amino acid-n-carboxyanhydrides using flash chromatography. Biomacromolecules 2010 Dec 13;11(12):3668-72

Kramer JR, Deming TJ, Glycopolypeptides via living polymerization of glycosylated-L-lysine N-carboxyanhydrides. J Am Chem Soc 2010 Oct 27;132(42):15068-71