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Lucas H. Timmins
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Phone: 801-581-8112
Office: 2474 MEB

Lucas H. Timmins

Post-doc, Biomedical Engineering, Georgia Tech; Cardiology, Emory University School of Medicine
Ph.D., Biomedical Engineering, Texas A&M University
B.S., Biomedical Engineering, Texas A&M University

Research

Vascular biomechanics; Computational and experimental biomechanics; Medical device design


Current Research

*accepting applications for PhD students (rotations) to begin August 2017

Our lab is focused on understanding the complex and interrelated mechanical, structural, and biological alterations that results in the degeneration of cardiovascular tissue from a normal to pathologic state. We develop and apply computational and experimental techniques to address clinically important problems in cardiovascular disease, including: elucidating mechanically influenced biologic mechanisms, evaluating the structure-function relationship in vascular tissues, and establishing engineering techniques to advance clinical diagnosis and prognosis. Given the multidisciplinary nature of our research, the laboratory enjoys active collaborations with engineers, scientists, and clinicians.


Selected Publications

Kim CW, Pokutta-Paskaleva A, Kumar S, Timmins LH, Morris AD, Kang DW, Dalal S, Chadid T, Kuo KM, Raykin J, Li H, Yanagisawa H, Gleason RL Jr, Jo H, Brewster LP, Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1. Circulation 2017 Sep 26;136(13):1217-1232

Birjiniuk J, Timmins LH, Young M, Leshnower BG, Oshinski JN, Ku DN, Veeraswamy RK, Pulsatile Flow Leads to Intimal Flap Motion and Flow Reversal in an In Vitro Model of Type B Aortic Dissection. Cardiovasc Eng Technol 2017 Jun 12;:

Timmins LH, Molony DS, Eshtehardi P, McDaniel MC, Oshinski JN, Giddens DP, Samady H, Oscillatory wall shear stress is a dominant flow characteristic affecting lesion progression patterns and plaque vulnerability in patients with coronary artery disease. J R Soc Interface 2017 Feb;14(127):

Timmins LH, Molony DS, Eshtehardi P, McDaniel MC, Oshinski JN, Samady H, Giddens DP, Focal association between wall shear stress and clinical coronary artery disease progression. Ann Biomed Eng 2015 Jan;43(1):94-106

Timmins LH, Mackie BD, Oshinski JN, Giddens DP, Samady H, Colocalization of low and oscillatory coronary wall shear stress with subsequent culprit lesion resulting in myocardial infarction in an orthotopic heart transplant patient. JACC Cardiovasc Interv 2013 Nov;6(11):1210-1

Timmins LH, Suever JD, Eshtehardi P, McDaniel MC, Oshinski JN, Samady H, Giddens DP, Framework to co-register longitudinal virtual histology-intravascular ultrasound data in the circumferential direction. IEEE Trans Med Imaging 2013 Nov;32(11):1989-96

Samady H, Eshtehardi P, McDaniel MC, Suo J, Dhawan SS, Maynard C, Timmins LH, Quyyumi AA, Giddens DP, Coronary artery wall shear stress is associated with progression and transformation of atherosclerotic plaque and arterial remodeling in patients with coronary artery disease. Circulation 2011 Aug 16;124(7):779-88

Timmins LH, Miller MW, Clubb FJ Jr, Moore JE Jr, Increased artery wall stress post-stenting leads to greater intimal thickening. Lab Invest 2011 Jun;91(6):955-67

Timmins LH, Wu Q, Yeh AT, Moore JE Jr, Greenwald SE, Structural inhomogeneity and fiber orientation in the inner arterial media. Am J Physiol Heart Circ Physiol 2010 May;298(5):H1537-45

Timmins LH, Moreno MR, Meyer CA, Criscione JC, Rachev A, Moore JE Jr, Stented artery biomechanics and device design optimization. Med Biol Eng Comput 2007 May;45(5):505-13