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David  Krizaj
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David Krizaj

Professor of Ophthalmology & Visual Sciences
Adjunct Professor of Neurobiology & Anatomy
Adjunct Professor, Bioengineering
graduate - New York University
postdoctoral - University of California San Francisco

Research

Visual signaling, mechanotransduction, nanoscaffold models of aqueous outflow


Selected Publications

Jo AO, Noel JM, Lakk M, Yarishkin O, Ryskamp DA, Shibasaki K, McCall MA, Križaj D, Mouse retinal ganglion cell signalling is dynamically modulated through parallel anterograde activation of cannabinoid and vanilloid pathways. J Physiol 2017 Aug 2;:

Phuong TTT, Redmon SN, Yarishkin O, Winter JM, Li DY, Križaj D, Calcium influx through TRPV4 channels modulates the adherens contacts between retinal microvascular endothelial cells. J Physiol 2017 Sep 26;:

Lakk M, Yarishkin O, Baumann JM, Iuso A, Križaj D, Cholesterol regulates polymodal sensory transduction in Müller glia. Glia 2017 Aug 30;:

Butler MR, Ma H, Yang F, Belcher J, Le YZ, Mikoshiba K, Biel M, Michalakis S, Iuso A, Križaj D, Ding XQ, Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency. J Biol Chem 2017 Jul 7;292(27):11189-11205

Toft-Bertelsen TL, Križaj D, MacAulay N, When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor. J Physiol 2017 Jun 1;595(11):3287-3302

Phuong TT, Yarishkin O, Križaj D, Subcellular propagation of calcium waves in Müller glia does not require autocrine/paracrine purinergic signaling. Channels (Austin) 2016 Sep 2;10(5):421-427

Ryskamp DA, Frye AM, Phuong TT, Yarishkin O, Jo AO, Xu Y, Lakk M, Iuso A, Redmon SN, Ambati B, Hageman G, Prestwich GD, Torrejon KY, Križaj D, TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye. Sci Rep 2016 Aug 11;6:30583

Jo AO, Lakk M, Frye AM, Phuong TT, Redmon SN, Roberts R, Berkowitz BA, Yarishkin O, Križaj D, Differential volume regulation and calcium signaling in two ciliary body cell types is subserved by TRPV4 channels. Proc Natl Acad Sci U S A 2016 Apr 5;113(14):3885-90

Molnár T, Yarishkin O, Iuso A, Barabas P, Jones B, Marc RE, Phuong TT, Križaj D, Store-Operated Calcium Entry in Müller Glia Is Controlled by Synergistic Activation of TRPC and Orai Channels. J Neurosci 2016 Mar 16;36(11):3184-98

Iuso A, Križaj D, TRPV4-AQP4 interactions 'turbocharge' astroglial sensitivity to small osmotic gradients. Channels (Austin) 2016;10(3):172-4

Križaj D, Polymodal Sensory Integration in Retinal Ganglion Cells. Adv Exp Med Biol 2016;854:693-8

Barabas P, Gorusupudi A, Bernstein PS, Krizaj D, Mouse Models of Stargardt 3 Dominant Macular Degeneration. Adv Exp Med Biol 2016;854:137-43

Cahoon JM, Rai RR, Carroll LS, Uehara H, Zhang X, O'Neil CL, Medina RJ, Das SK, Muddana SK, Olson PR, Nielson S, Walker K, Flood MM, Messenger WB, Archer BJ, Barabas P, Krizaj D, Gibson CC, Li DY, Koh GY, Gao G, Stitt AW, Ambati BK, Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy. Diabetes 2015 Dec;64(12):4247-59

Jo AO, Ryskamp DA, Phuong TT, Verkman AS, Yarishkin O, MacAulay N, Križaj D, TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia. J Neurosci 2015 Sep 30;35(39):13525-37

Ryskamp DA, Jo AO, Frye AM, Vazquez-Chona F, MacAulay N, Thoreson WB, Križaj D, Swelling and eicosanoid metabolites differentially gate TRPV4 channels in retinal neurons and glia. J Neurosci 2014 Nov 19;34(47):15689-700

Deering-Rice CE, Mitchell VK, Romero EG, Abdel Aziz MH, Ryskamp DA, Križaj D, Gopal VR, Reilly CA, Drofenine: A 2-APB Analogue with Greater Selectivity for Human TRPV3. Pharmacol Res Perspect 2014 Oct;2(5):e00062

Ryskamp DA, Redmon S, Jo AO, Križaj D, TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision. Cells 2014 Sep 12;3(3):914-38

Chen M, Križaj D, Thoreson WB, Intracellular calcium stores drive slow non-ribbon vesicle release from rod photoreceptors. Front Cell Neurosci 2014;8:20

Luo L, Zhang X, Hirano Y, Tyagi P, Barabás P, Uehara H, Miya TR, Singh N, Archer B, Qazi Y, Jackman K, Das SK, Olsen T, Chennamaneni SR, Stagg BC, Ahmed F, Emerson L, Zygmunt K, Whitaker R, Mamalis C, Huang W, Gao G, Srinivas SP, Krizaj D, Baffi J, Ambati, Targeted intraceptor nanoparticle therapy reduces angiogenesis and fibrosis in primate and murine macular degeneration. ACS Nano 2013 Apr 23;7(4):3264-75

Barabas P, Liu A, Xing W, Chen CK, Tong Z, Watt CB, Jones BW, Bernstein PS, Križaj D, Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration. Proc Natl Acad Sci U S A 2013 Mar 26;110(13):5181-6

Molnar T, Barabas P, Birnbaumer L, Punzo C, Kefalov V, Križaj D, Store-operated channels regulate intracellular calcium in mammalian rods. J Physiol 2012 Aug 1;590(15):3465-81

Križaj D, Calcium stores in vertebrate photoreceptors. Adv Exp Med Biol 2012;740:873-89

Xing W, Akopian A, Križaj D, Trafficking of presynaptic PMCA signaling complexes in mouse photoreceptors requires Cav1.4 a1 subunits. Adv Exp Med Biol 2012;723:739-44

Huang W, Xing W, Ryskamp DA, Punzo C, Križaj D, Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strains. Exp Eye Res 2011 Nov;93(5):700-9

Barabas P, Huang W, Chen H, Koehler CL, Howell G, John SW, Tian N, Rentería RC, Krizaj D, Missing optomotor head-turning reflex in the DBA/2J mouse. Invest Ophthalmol Vis Sci 2011 Aug 29;52(9):6766-73

Ryskamp DA, Witkovsky P, Barabas P, Huang W, Koehler C, Akimov NP, Lee SH, Chauhan S, Xing W, Rentería RC, Liedtke W, Krizaj D, The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells. J Neurosci 2011 May 11;31(19):7089-101

Krizaj D, Mercer AJ, Thoreson WB, Barabas P, Intracellular pH modulates inner segment calcium homeostasis in vertebrate photoreceptors. Am J Physiol Cell Physiol 2011 Jan;300(1):C187-97

Križaj D, Huang W, Furukawa T, Punzo C, Xing W, Plasticity of TRPM1 expression and localization in the wild type and degenerating mouse retina. Vision Res 2010 Nov 23;50(23):2460-5

Barabas P, Cutler Peck C, Krizaj D, Do calcium channel blockers rescue dying photoreceptors in the Pde6b ( rd1 ) mouse? Adv Exp Med Biol 2010;664:491-9