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Douglas A. Christensen

Phone: 801-581-7859
Office: 2456 MEB

Douglas A. Christensen

Advisor, Undergraduate Minor Program
BSEE - Brigham Young University
MS - Stanford University
PhD - University of Utah


Waves used for biomedical applications, including therapeutic ultrasound, ultrasonic imaging and optical biosensors.

Current Research

For additional information, including recent teaching assignments, patents and conference presentations, please visit my HOME PAGE.

Current research projects include:

Modeling of Therapeutic Ultrasound: Ultrasound can be used as an energy delivery means. It has found use as a drug-delivery modality, in bone healing, and in tissue heating and ablation. To model the path of the ultrasound beam in imhomogeneous tissue, we have developed a numerical technique called the fast hybrid angular spectrum method (HAS). This project is in collaboration with Profs. Bob Roemer, Dennis Parker and Mikhail Skliar.

Below are some selected additional publications that are not listed in the PubMed "Selected Publications" collection (at the very bottom of this page):

-J. D. Andrade, J. N. Lin, V. Hlady, J. Herron, D. A. Christensen, and J. Kopecek, "Immunosensors: Remaining Problems in the Development of Remote, Continuous, Multi-Channel Devices," Biosensor Technology, R. B. Buck, et al., eds., Dekker, 1990.
-J.N. Lin, I.N. Chang, J.D. Andrade, J.N. Herron, and D.A. Christensen, "Comparison of Site-Specific Coupling Chemistry for Antibody Immobilization on Different Solid Supports," Journal of Chromatography, Vol. 542, pp. 41-54, 1991.
-W. Sui, D.A. Christensen, and C.H. Durney, "Extending the Two-Dimensional FDTD Method to Hybrid Electromagnetic Systems with Active and Passive Lumped Elements," IEEE Transactions on Microwave Theory and Techniques, Vol. 40, pp. 724-730, April 1992.
-R.B. Gwynn and D.A. Christensen, "A Method for Accurate Optical Alignment Using Diffraction Rings from Lenses with Spherical Aberration," Applied Optics, Vol. 32, No. 7, pp. 1210-1215, March 1993.
-D.A. Christensen, J. Rotge, A. Klemas, G. Loos, and D. Merriman, "Laser Diode Coherence Length Variation for Balancing Fiber Optic Interferometers,” Optical Engineering, Vol. 33, No. 6, pp. 2034-2038, June 1994.
-D.A. Christensen, T. Johansson, and D. Petelenz, "Biosensor Development at the University of Utah," Engineering in Medicine and Biology, Vol. 13, No. 3, pp. 388-395, June/July 1994.
-D.A. Christensen, "Analysis of Near Field Tip Patterns Including Object Interaction Using Finite-Difference Time-Domain Calculations," Ultramicroscopy, Vol. 57, Nos. 2/3, pp. 189-195, February 1995.
-D.N. Buechler, D. H. Roper, C. H. Durney, and D. A. Christensen, "Modeling Sources in the FDTD Formulation and Their Use in Quantifying Source and Boundary Condition Errors," IEEE Transactions on Microwave Theory and Techniques, Vol. 43, No. 4, pp. 810-814, April 1995.
-T.E. Plowman, W. M. Reichert, C. R. Peters, H. K. Wang, D. A. Christensen, and J. N. Herron, "Femtomolar Sensitivity Using a Channel-etched Thin Film Waveguide Fluoroimmunosensor," Biosensors and Bioelectronics, Vol. 11, No. 1/2, pp. 149-160, 1996.
-C.H. Durney, W. Sui, D. A. Christensen, and J. Zhu, "A General Formulation for Connecting Sources and Passive Lumped-Circuit Elements Across Multiple 3-D FDTD Cells," IEEE Microwave and Guided Wave Letters, Vol. 6, No. 2, pp. 85-87, February 1996.
-D.A. Christensen and D. Fowers, "Modeling SPR Sensors with the Finite-Difference Time-Domain Method," Biosensors and Bioelectronics, Vol. 11, No. 6/7, pp. 677-684, 1996.
-S.D. Dyer and D.A. Christensen, "Dispersion Effects in Fiber Optic Interferometry," Optical Engineering, vol. 36, no. 9, pp. 2440-2447, September 1997.
-T.E. Plowman, J.D. Durtschi, H-K Wang, D.A. Christensen, J.N. Herron and W.M. Reichert, “Multiple-analyte Fluoroimmunoassay using an Integrated Optical Waveguide Sensor,” Analytical Chemistry, vol. 71, pp. 4344-4352, 1999.
-C.M. Furse, D.H. Roper, D.N. Buechler, D.A. Christensen, and C.H. Durney, "The Problem and Treatment of DC Offsets in FDTD Simulations," IEEE Transactions on Antennas and Propagation, vol. 48, pp. 1198-1201, August 2000.
-D.N. Buechler, D.A. Christensen, C.H. Durney and B.J. Simon, “Calculation of Electric Fields in the Human Knee Produced by a Knee-Thigh Electrode Pair,” Applied Computational Electromagneti

Selected Publications

Iversen MM, Christensen DA, Parker DL, Holman HA, Chen J, Frerck MJ, Rabbitt RD, Low-intensity ultrasound activates vestibular otolith organs through acoustic radiation force. J Acoust Soc Am 2017 Jun;141(6):4209

Farrer AI, Almquist S, Dillon CR, Neumayer LA, Parker DL, Christensen DA, Payne A, Phase aberration simulation study of MRgFUS breast treatments. Med Phys 2016 Mar;43(3):1374-84

Odéen H, Almquist S, de Bever J, Christensen DA, Parker DL, MR thermometry for focused ultrasound monitoring utilizing model predictive filtering and ultrasound beam modeling. J Ther Ultrasound 2016;4:23

Almquist S, Parker DL, Christensen DA, Rapid full-wave phase aberration correction method for transcranial high-intensity focused ultrasound therapies. J Ther Ultrasound 2016;4:30

Payne A, de Bever J, Farrer A, Coats B, Parker DL, Christensen DA, A simulation technique for 3D MR-guided acoustic radiation force imaging. Med Phys 2015 Feb;42(2):674-84

Farrer AI, Odéen H, de Bever J, Coats B, Parker DL, Payne A, Christensen DA, Characterization and evaluation of tissue-mimicking gelatin phantoms for use with MRgFUS. J Ther Ultrasound 2015;3:9

Dillon CR, Payne A, Christensen DA, Roemer RB, The accuracy and precision of two non-invasive, magnetic resonance-guided focused ultrasound-based thermal diffusivity estimation methods. Int J Hyperthermia 2014 Sep;30(6):362-71

Odéen H, de Bever J, Almquist S, Farrer A, Todd N, Payne A, Snell JW, Christensen DA, Parker DL, Treatment envelope evaluation in transcranial magnetic resonance-guided focused ultrasound utilizing 3D MR thermometry. J Ther Ultrasound 2014;2:19

Dillon CR, Todd N, Payne A, Parker DL, Christensen DA, Roemer RB, Effects of MRTI sampling characteristics on estimation of HIFU SAR and tissue thermal diffusivity. Phys Med Biol 2013 Oct 21;58(20):7291-307

Dillon CR, Vyas U, Payne A, Christensen DA, Roemer RB, An analytical solution for improved HIFU SAR estimation. Phys Med Biol 2012 Jul 21;57(14):4527-44

Brinton MR, Tagge CA, Stewart RJ, Cheung AK, Shiu YT, Christensen DA, Thermal sensitivity of endothelial cells on synthetic vascular graft material. Int J Hyperthermia 2012;28(2):163-74

Vyas U, Christensen DA, Extension of the angular spectrum method to calculate pressure from a spherically curved acoustic source. J Acoust Soc Am 2011 Nov;130(5):2687-93

Brinton MR, Stewart RJ, Cheung AK, Christensen DA, Shiu YT, Modelling ultrasound-induced mild hyperthermia of hyperplasia in vascular grafts. Theor Biol Med Model 2011 Nov 3;8:42

Payne A, Vyas U, Todd N, de Bever J, Christensen DA, Parker DL, The effect of electronically steering a phased array ultrasound transducer on near-field tissue heating. Med Phys 2011 Sep;38(9):4971-81

Duer R, Lund R, Tanaka R, Christensen DA, Herron JN, In-plane parallel scanning: a microarray technology for point-of-care testing. Anal Chem 2010 Nov 1;82(21):8856-65

Rapoport N, Christensen DA, Kennedy AM, Nam KH, Cavitation properties of block copolymer stabilized phase-shift nanoemulsions used as drug carriers. Ultrasound Med Biol 2010 Mar;36(3):419-29

Hu N, Christensen DA, Agrawal AK, Beaumont C, Clark EB, Hawkins JA, Dependence of aortic arch morphogenesis on intracardiac blood flow in the left atrial ligated chick embryo. Anat Rec (Hoboken) 2009 May;292(5):652-60

Rapoport NY, Efros AL, Christensen DA, Kennedy AM, Nam KH, Microbubble Generation in Phase-Shift Nanoemulsions used as Anticancer Drug Carriers. Bubble Sci Eng Technol 2009;1(1-2):31-39

Christensen DA, Herron JN, Optical system design for biosensors based on CCD detection. Methods Mol Biol 2009;503:239-58

Gao Z, Kennedy AM, Christensen DA, Rapoport NY, Drug-loaded nano/microbubbles for combining ultrasonography and targeted chemotherapy. Ultrasonics 2008 Aug;48(4):260-70

Hagmann MJ, Christensen DA, Mousa MS, Baturin A, Sheshin EP, Anomalous high-frequency oscillations in a field emission tube and their significance in pulsed field emission. Ultramicroscopy 2007 Sep;107(9):854-6

Husseini GA, Diaz de la Rosa MA, Richardson ES, Christensen DA, Pitt WG, The role of cavitation in acoustically activated drug delivery. J Control Release 2005 Oct 3;107(2):253-61

Rapoport NY, Christensen DA, Fain HD, Barrows L, Gao Z, Ultrasound-triggered drug targeting of tumors in vitro and in vivo. Ultrasonics 2004 Apr;42(1-9):943-50

Christensen DA, Horch KW, Experience with the first three years of an accelerated dual-degree program in biomedical engineering. Conf Proc IEEE Eng Med Biol Soc 2004;7:5149-51

Tolley SE, Wang HK, Smith RS, Christensen DA, Herron JN, Single-chain polymorphism analysis in long QT syndrome using planar waveguide fluorescent biosensors. Anal Biochem 2003 Apr 15;315(2):223-37

Marin A, Sun H, Husseini GA, Pitt WG, Christensen DA, Rapoport NY, Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake. J Control Release 2002 Nov 7;84(1-2):39-47

Buechler DN, Christensen DA, Durney CH, Simon B, Calculation of electric fields induced in the human knee by a coil applicator. Bioelectromagnetics 2001 May;22(4):224-31

Husseini GA, Myrup GD, Pitt WG, Christensen DA, Rapoport NY, Factors affecting acoustically triggered release of drugs from polymeric micelles. J Control Release 2000 Oct 3;69(1):43-52

Dyer SD, Christensen DA, Pupil-size effects in fiber optic stellar interferometry. J Opt Soc Am A Opt Image Sci Vis 1999 Sep;16(9):2275-80

Buechler DN, Durney CH, Christensen DA, Calculation of electric fields induced near metal implants by magnetic resonance imaging switched-gradient magnetic fields. Magn Reson Imaging 1997;15(10):1157-66

Hendee SP, Faour FA, Christensen DA, Patrick B, Durney CH, Blumenthal DK, The effects of weak extremely low frequency magnetic fields on calcium/calmodulin interactions. Biophys J 1996 Jun;70(6):2915-23

Shaw JA, Durney CH, Christensen DA, Computer-aided design of two-dimensional electric-type hyperthermia applicators using the finite-difference time-domain method. IEEE Trans Biomed Eng 1991 Sep;38(9):861-70

Decker-Dunn D, Christensen DA, Vincent GM, Multifiber gradient-index lens laser angioplasty probe. Lasers Surg Med 1990;10(1):85-93