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Claire  Acevedo
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Claire Acevedo

Assistant Professor, Mechanical Engineering
Adjunct Assistant Professor, Biomedical Engineering
Adjunct Assistant Professor, Bioengineering

Research

Skeletal tissues, Biomechanics, fracture mechanics, fatigue, multiscale approach, synchrotron x-ray radiation experiments


Current Research

Our research in the Fatigue and Fracture of Skeletal Tissues Lab is bridging the gap between fracture mechanics, material characterization and biology. We aim at investigating the structure, function mechanisms and dynamics of skeletal tissues using an experimental multi-scale approach.

Since skeletal tissues and biological materials derive their structural integrity from the molecular to millimetre length-scales, we investigate their hierarchical structure, deformation/fracture mechanisms, and biological activities using advanced x-ray synchrotron instrumentations designed to capture behavior at these multiple dimensions as well as macroscale mechanical testing (strength, toughness and fatigue tests).

Using this multi-scale experimental approach, we have successfully explored highly diverse biosamples (bones from human and animal models, intervertebral discs, fish scale, skin, mantis shrimp telson, etc.) and bone fragility associated with diseases (osteonecrosis, diabetes, osteoporosis, osteogenesis imperfecta), treatments (bisphosphonate and corticosteroid) or Fatigue loading. This work provided a foundation for understanding mechanisms by which the bone’s resistance to fracture can be impaired by disease or treatment.

Synchrotron-based engineering science is pushing the limits of knowledge in biological sciences and other new possibilities for scientific discovery.