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Edward W. Hsu

Phone: 801 585-7550
Office: 1242 SMBB

Edward W. Hsu

Ph.D. in Biomedical Engineering, Johns Hopkins University School of Medicine
B.A.Sc. in Engineering Physics, University of British Columbia


magnetic resonance imaging and microscopy, and tissue functional anatomy

Current Research

Functional properties of tissues are highly dependent on their microstructure. For example, electrical conduction of the myocardium and mechanical coupling in the intervertebral disc are mediated by their respective fiber architecture. Our research is devoted to (a) the development of nondestructive techniques to quantitatively assess tissue microstructure, and (b) the integration of structure and morphologically-accurate models of tissue function. A promising approach is to combine high-resolution magnetic resonance imaging and diffusion tensor visualization. The latter is sensitive to the anisotropic diffusion of water present in ordered tissues.

Selected Publications

Gomez AD, Zou H, Bowen ME, Liu X, Hsu EW, McKellar SH, Right Ventricular Fiber Structure as a Compensatory Mechanism in Pressure Overload: A Computational Study. J Biomech Eng 2017 Aug 1;139(8):

Abdullah OM, Seidel T, Dahl M, Gomez AD, Yiep G, Cortino J, Sachse FB, Albertine KH, Hsu EW, Diffusion tensor imaging and histology of developing hearts. NMR Biomed 2016 Oct;29(10):1338-49

Abdullah OM, Gomez AD, Merchant S, Heidinger M, Poelzing S, Hsu EW, Orientation dependence of microcirculation-induced diffusion signal in anisotropic tissues. Magn Reson Med 2016 Oct;76(4):1252-62

Merchant SS, Gomez AD, Morgan JL, Hsu EW, Parametric Modeling of the Mouse Left Ventricular Myocardial Fiber Structure. Ann Biomed Eng 2016 Sep;44(9):2661-73

Merchant SS, Kosaka Y, Yost HJ, Hsu EW, Brunelli L, Micro-Computed Tomography for the Quantitative 3-Dimensional Assessment of the Compact Myocardium in the Mouse Embryo. Circ J 2016 Jul 25;80(8):1795-803

Winters AA, Bou-Ghannam S, Thorp H, Hawayek JA, Atkinson DL, Bartlett CE, Silva FJ, Hsu EW, Moreno AP, Grainger DA, Patel AN, Evaluation of Multiple Biological Therapies for Ischemic Cardiac Disease. Cell Transplant 2016;25(9):1591-1607

Sun CY, Zhu YM, Chu CY, Yang F, Liu WY, Korenberg JR, Hsu EW, Assessment of the Characteristics of Orientation Distribution Functions in HARDI Using Morphological Metrics. PLoS One 2016;11(2):e0150161

McKellar SH, Javan H, Bowen ME, Liu X, Schaaf CL, Briggs CM, Zou H, Gomez AD, Abdullah OM, Hsu EW, Selzman CH, Animal model of reversible, right ventricular failure. J Surg Res 2015 Apr;194(2):327-33

Gomez AD, Zou H, Shiu YT, Hsu EW, Characterization of regional deformation and material properties of the intact explanted vein by microCT and computational analysis. Cardiovasc Eng Technol 2014 Dec;5(4):359-370

Abdullah OM, Drakos SG, Diakos NA, Wever-Pinzon O, Kfoury AG, Stehlik J, Selzman CH, Reid BB, Brunisholz K, Verma DR, Myrick C, Sachse FB, Li DY, Hsu EW, Characterization of diffuse fibrosis in the failing human heart via diffusion tensor imaging and quantitative histological validation. NMR Biomed 2014 Nov;27(11):1378-86

Welsh CL, Dibella EV, Adluru G, Hsu EW, Model-based reconstruction of undersampled diffusion tensor k-space data. Magn Reson Med 2013 Aug;70(2):429-40

Towner RA, Gillespie DL, Schwager A, Saunders DG, Smith N, Njoku CE, Krysiak RS 3rd, Larabee C, Iqbal H, Floyd RA, Bourne DW, Abdullah O, Hsu EW, Jensen RL, Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007. Neuro Oncol 2013 Jan 17;:

Healy LJ, Jiang Y, Hsu EW, Quantitative comparison of myocardial fiber structure between mice, rabbit, and sheep using diffusion tensor cardiovascular magnetic resonance. J Cardiovasc Magn Reson 2011 Nov 25;13:74

Deren KE, Packer M, Forsyth J, Milash B, Abdullah OM, Hsu EW, McAllister JP 2nd, Reactive astrocytosis, microgliosis and inflammation in rats with neonatal hydrocephalus. Exp Neurol 2010 Nov;226(1):110-9

Lee JN, Hsu EW, Rashkin E, Thatcher JW, Kreitschitz S, Gale P, Healy L, Marchand WR, Reliability of fMRI motor tasks in structures of the corticostriatal circuitry: Implications for future studies and circuit function. Neuroimage 2009 Oct 7;:

Deren KE, Forsyth J, Abdullah O, Hsu EW, Klinge PM, Silverberg GD, Johanson CE, McAllister JP 2nd, Low levels of amyloid-beta and its transporters in neonatal rats with and without hydrocephalus. Cerebrospinal Fluid Res 2009 May 26;6:4

Marchand WR, Lee JN, Thatcher JW, Hsu EW, Rashkin E, Suchy Y, Chelune G, Starr J, Barbera SS, Putamen coactivation during motor task execution. Neuroreport 2008 Jun 11;19(9):957-60

Mistry NN, Hsu E , Retrospective distortion correction for 3D MR diffusion tensor microscopy using mutual information and fourier deformations. Magn Reson Med 2006 Jun 13;:

Chen B, Hsu E , Noise removal in magnetic resonance diffusion tensor imaging. Magn Reson Med 2005 Aug;54(2):393-401

Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Fata B, Hsu EW, Saloner D, Guccione J , MRI-based finite-element analysis of left ventricular aneurysm. Am J Physiol Heart Circ Physiol 2005 Aug;289(2):H692-700

Walker JC, Guccione JM, Jiang Y, Zhang P, Wallace AW, Hsu EW, Ratcliffe M , Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheep. J Thorac Cardiovasc Surg 2005 Feb;129(2):382-90

Jiang Y, Hsu E , Accelerating MR diffusion tensor imaging via filtered reduced-encoding projection-reconstruction. Magn Reson Med 2005 Jan;53(1):93-102

Jiang Y, Pandya K, Smithies O, Hsu E , Three-dimensional diffusion tensor microscopy of fixed mouse hearts. Magn Reson Med 2004 Sep;52(3):453-60

Gilchrist CL, Xia JQ, Setton LA, Hsu E , High-resolution determination of soft tissue deformations using MRI and first-order texture correlation. IEEE Trans Med Imaging 2004 May;23(5):546-53

Taylor WD, Hsu E, Krishnan KR, MacFall J , Diffusion tensor imaging: background, potential, and utility in psychiatric research. Biol Psychiatry 2004 Feb 1;55(3):201-7

Muzikant AL, Hsu EW, Wolf PD, Henriquez C , Region specific modeling of cardiac muscle: comparison of simulated and experimental potentials. Ann Biomed Eng 2002 Jul-Aug;30(7):867-83

Wolfe SP, Hsu E, Reid LM, Macdonald J , A novel multi-coaxial hollow fiber bioreactor for adherent cell types. Part 1: hydrodynamic studies. Biotechnol Bioeng 2002 Jan 5;77(1):83-90

Hsu EW, Buckley DL, Bui JD, Blackband SJ, Forder J , Two-component diffusion tensor MRI of isolated perfused hearts. Magn Reson Med 2001 Jun;45(6):1039-45

Hsu EW, Henriquez C , Myocardial fiber orientation mapping using reduced encoding diffusion tensor imaging. J Cardiovasc Magn Reson 2001;3(4):339-47

Setton LA, Guilak F, Hsu EW, Vail T , Biomechanical factors in tissue engineered meniscal repair. Clin Orthop Relat Res 1999 Oct;(367 Suppl):S254-72

Hsu EW, Setton L , Diffusion tensor microscopy of the intervertebral disc anulus fibrosus. Magn Reson Med 1999 May;41(5):992-9

Hsu EW, Hedlund LW, MacFall J , Functional MRI of the rat somatosensory cortex: effects of hyperventilation. Magn Reson Med 1998 Sep;40(3):421-6

Hsu EW, Reeder SB, MacFall J , Single-shot, variable flip-angle slice-selective excitation with four gradient-modulated adiabatic half-passage segments. Magn Reson Med 1998 Aug;40(2):334-40

Hsu EW, Xue R, Holmes A, Forder J , Delayed reduction of tissue water diffusion after myocardial ischemia. Am J Physiol 1998 Aug;275(2 Pt 2):H697-702

Hsu EW, Muzikant AL, Matulevicius SA, Penland RC, Henriquez C , Magnetic resonance myocardial fiber-orientation mapping with direct histological correlation. Am J Physiol 1998 May;274(5 Pt 2):H1627-34

Hagedorn M, Kleinhans FW, Freitas R, Liu J, Hsu EW, Wildt DE, Rall W , Water distribution and permeability of zebrafish embryos, Brachydanio rerio. J Exp Zool 1997 Aug 15;278(6):356-71

Hagedorn M, Hsu E, Kleinhans FW, Wildt D , New approaches for studying the permeability of fish embryos: toward successful cryopreservation. Cryobiology 1997 Jun;34(4):335-47

Hsu EW, Aiken NR, Blackband S , A study of diffusion isotropy in single neurons by using NMR microscopy. Magn Reson Med 1997 Apr;37(4):624-7

Hsu EW, Aiken NR, Blackband S , Nuclear magnetic resonance microscopy of single neurons under hypotonic perturbation. Am J Physiol 1996 Dec;271(6 Pt 1):C1895-900

Aiken NR, Hsu EW, Horsman A, Blackband S , Maturation effects on the NMR microimaging characteristics of single neurons. Am J Physiol 1996 Oct;271(4 Pt 1):C1295-302

Hagedorn M, Hsu EW, Pilatus U, Wildt DE, Rall WR, Blackband S , Magnetic resonance microscopy and spectroscopy reveal kinetics of cryoprotectant permeation in a multicompartmental biological system. Proc Natl Acad Sci U S A 1996 Jul 23;93(15):7454-9

Hsu EW, Schoeniger JS, Bowtell R, Aiken NR, Horsman A, Blackband S , A modified imaging sequence for accurate T2 measurements using NMR microscopy. J Magn Reson B 1995 Oct;109(1):66-9

Hsu EW, Mori , Analytical expressions for the NMR apparent diffusion coefficients in an anisotropic system and a simplified method for determining fiber orientation. Magn Reson Med 1995 Aug;34(2):194-200

Bowtell RW, Peters A, Sharp JC, Mansfield P, Hsu EW, Aiken N, Horsman A, Blackband S , NMR microscopy of single neurons using spin echo and line narrowed 2DFT imaging. Magn Reson Med 1995 Jun;33(6):790-4

Schoeniger JS, Aiken N, Hsu E, Blackband S , Relaxation-time and diffusion NMR microscopy of single neurons. J Magn Reson B 1994 Mar;103(3):261-73