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Kuberan  Balagurunathan

Phone: 801 587-9474
Office: BPRB 295C

Kuberan Balagurunathan

Professor of Medicinal Chemistry
Adjunct Professor, Bioengineering

Current Research

Chemical biology of cell surface-bound carbohydrates such as heparan, chondroitin, dermatan and keratan sulfates. Determining their pathological and physiological roles at the molecular level. Designing new carbohydrate-based drugs

Selected Publications

Bhushan I, Alabbas A, Kuberan B, Gupta RB, Desai UR, IMMOBILIZATION ALTERS HEPARIN CLEAVING PROPERTIES OF HEPARINASE I. Glycobiology 2017 Aug 22;:

Bi Y, Might M, Vankayalapati H, Kuberan B, Repurposing of Proton Pump Inhibitors as first identified small molecule inhibitors of endo-▀-N-acetylglucosaminidase (ENGase) for the treatment of NGLY1 deficiency, a rare genetic disease. Bioorg Med Chem Lett 2017 Jul 1;27(13):2962-2966

Mencio C, Kuberan B, Goller F, Contributions of rapid neuromuscular transmission to the fine control of acoustic parameters of birdsong. J Neurophysiol 2017 Feb 1;117(2):637-645

Chua JS, Tran VM, Kalita M, Quintero MV, Antelope O, Muruganandam G, Saijoh Y, Kuberan B, A glycan-based approach to therapeutic angiogenesis. PLoS One 2017;12(8):e0182301

Holman HA, Tran VM, Kalita M, Nguyen LN, Arungundram S, Kuberan B, Rabbitt RD, BODIPY-Conjugated Xyloside Primes Fluorescent Glycosaminoglycans in the Inner Ear of Opsanus tau. J Assoc Res Otolaryngol 2016 Dec;17(6):525-540

Brown S, Kuberan B, Production of size-defined heparosan, heparan sulfate, and heparin oligosaccharides by enzymatic depolymerization. Methods Mol Biol 2015;1229:21-9

Raman K, Kuberan B, Arungundram S, Chemical modification of heparin and heparosan. Methods Mol Biol 2015;1229:31-6

Mencio C, Swarup VP, Soliai M, Kuberan B, Synthesis of sulfur isotope-labeled sulfate donor, 3'-phosphoadenosine-5'-phosphosulfate, for studying glycosaminoglycan functions. Methods Mol Biol 2015;1229:37-42

Victor XV, Tran VM, Kuberan B, Nguyen TK, Preparation of isotope-enriched heparan sulfate precursors for structural biology studies. Methods Mol Biol 2015;1229:43-8

Mencio C, Garud DR, Kuberan B, Koketsu M, Synthesis of selective inhibitors of heparan sulfate and chondroitin sulfate proteoglycan biosynthesis. Methods Mol Biol 2015;1229:69-78

Kalita M, Quintero MV, Raman K, Tran VM, Kuberan B, Synthesis and biomedical applications of xylosides. Methods Mol Biol 2015;1229:517-28

Joice A, Raman K, Mencio C, Quintero MV, Brown S, Nguyen TK, Kuberan B, Enzymatic synthesis of heparan sulfate and heparin. Methods Mol Biol 2015;1229:11-9

Foulcer SJ, Nelson CM, Quintero MV, Kuberan B, Larkin J, Dours-Zimmermann MT, Zimmermann DR, Apte SS, Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5. J Biol Chem 2014 Oct 3;289(40):27859-73

Raman K, Arungundram S, Kuberan B, Chemogenesis of an antiangiogenic glycosaminoglycan. ACS Med Chem Lett 2014 Jun 12;5(6):644-6

Tran VM, Kuberan B, Synthesis of fluorophore-tagged xylosides that prime glycosaminoglycan chains. Bioconjug Chem 2014 Feb 19;25(2):262-8

Kalita M, Balivada S, Swarup VP, Mencio C, Raman K, Desai UR, Troyer D, Kuberan B, A nanosensor for ultrasensitive detection of oversulfated chondroitin sulfate contaminant in heparin. J Am Chem Soc 2014 Jan 15;136(2):554-7

Karanth S, Tran VM, Kuberan B, Schlegel A, Polyunsaturated fatty acyl-coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice. Dis Model Mech 2013 Nov;6(6):1365-77

Swarup VP, Hsiao TW, Zhang J, Prestwich GD, Kuberan B, Hlady V, Exploiting differential surface display of chondroitin sulfate variants for directing neuronal outgrowth. J Am Chem Soc 2013 Sep 11;135(36):13488-94

Hsiao TW, Swarup VP, Kuberan B, Tresco PA, Hlady V, Astrocytes specifically remove surface-adsorbed fibrinogen and locally express chondroitin sulfate proteoglycans. Acta Biomater 2013 Jul;9(7):7200-8

Swarup VP, Mencio CP, Hlady V, Kuberan B, Sugar glues for broken neurons. Biomol Concepts 2013 Jun;4(3):233-57

Nguyen TK, Tran VM, Sorna V, Eriksson I, Kojima A, Koketsu M, Loganathan D, KjellÚn L, Dorsky RI, Chien CB, Kuberan B, Dimerized glycosaminoglycan chains increase FGF signaling during zebrafish development. ACS Chem Biol 2013 May 17;8(5):939-48

Tran VM, Nguyen TK, Sorna V, Loganathan D, Kuberan B, Synthesis and assessment of glycosaminoglycan priming activity of cluster-xylosides for potential use as proteoglycan mimetics. ACS Chem Biol 2013 May 17;8(5):949-57

Raman K, Mencio C, Desai UR, Kuberan B, Sulfation patterns determine cellular internalization of heparin-like polysaccharides. Mol Pharm 2013 Apr 1;10(4):1442-9

Raman K, Karuturi R, Swarup VP, Desai UR, Kuberan B, Discovery of novel sulfonated small molecules that inhibit vascular tube formation. Bioorg Med Chem Lett 2012 Jul 1;22(13):4467-70

Nguyen TK, Arungundram S, Tran VM, Raman K, Al-Mafraji K, Venot A, Boons GJ, Kuberan B, A synthetic heparan sulfate oligosaccharide library reveals the novel enzymatic action of D-glucosaminyl 3-O-sulfotransferase-3a. Mol Biosyst 2012 Feb;8(2):609-14

Raman K, Nguyen TK, Kuberan B, Is N-sulfation just a gateway modification during heparan sulfate biosynthesis? FEBS Lett 2011 Nov 4;585(21):3420-3

Nguyen TK, Raman K, Tran VM, Kuberan B, Investigating the mechanism of the assembly of FGF1-binding heparan sulfate motifs. FEBS Lett 2011 Sep 2;585(17):2698-702

Babu P, Victor XV, Nelsen E, Nguyen TK, Raman K, Kuberan B, Hydrogen/deuterium exchange-LC-MS approach to characterize the action of heparan sulfate C5-epimerase. Anal Bioanal Chem 2011 Jul;401(1):237-44

Raman K, Ninomiya M, Nguyen TK, Tsuzuki Y, Koketsu M, Kuberan B, Novel glycosaminoglycan biosynthetic inhibitors affect tumor-associated angiogenesis. Biochem Biophys Res Commun 2011 Jan 7;404(1):86-9

Tran VM, Nguyen TK, Raman K, Kuberan B, Applications of isotopes in advancing structural and functional heparanomics. Anal Bioanal Chem 2011 Jan;399(2):559-70

Tsuzuki Y, Nguyen TK, Garud DR, Kuberan B, Koketsu M, 4-deoxy-4-fluoro-xyloside derivatives as inhibitors of glycosaminoglycan biosynthesis. Bioorg Med Chem Lett 2010 Dec 15;20(24):7269-73

Nguyen TK, Tran VM, Victor XV, Skalicky JJ, Kuberan B, Characterization of uniformly and atom-specifically (13)C-labeled heparin and heparan sulfate polysaccharide precursors using (13)C NMR spectroscopy and ESI mass spectrometry. Carbohydr Res 2010 Oct 13;345(15):2228-32

Raman K, Kuberan B, Click-xylosides mitigate glioma cell invasion in vitro. Mol Biosyst 2010 Oct;6(10):1800-2

Tran VM, Victor XV, Yockman JW, Kuberan B, RGD-xyloside conjugates prime glycosaminoglycans. Glycoconj J 2010 Aug;27(6):625-33

Raman K, Kuberan B, Differential effects of Heparitinase I and Heparitinase III on endothelial tube formation in vitro. Biochem Biophys Res Commun 2010 Jul 23;398(2):191-3

Raman K, Kuberan B, Chemical Tumor Biology of Heparan Sulfate Proteoglycans. Curr Chem Biol 2010 Jan 1;4(1):20-31

Sigulinsky C, Babu P, Victor XV, Kuberan B, Preparation and characterization of (15)N-enriched, size-defined heparan sulfate precursor oligosaccharides. Carbohydr Res 2010 Jan 26;345(2):250-6

Babu P, Kuberan B, Fluorescent-tagged heparan sulfate precursor oligosaccharides to probe the enzymatic action of heparitinase I. Anal Biochem 2010 Jan 1;396(1):124-32

Victor XV, Nguyen TK, Ethirajan M, Tran VM, Nguyen KV, Kuberan B, Investigating the elusive mechanism of glycosaminoglycan biosynthesis. J Biol Chem 2009 Sep 18;284(38):25842-53

Garud DR, Tran VM, Victor XV, Koketsu M, Kuberan B, Inhibition of heparan sulfate and chondroitin sulfate proteoglycan biosynthesis. J Biol Chem 2008 Oct 24;283(43):28881-7

Kuberan B, Ethirajan M, Victor XV, Tran V, Nguyen K, Do A, "Click" xylosides initiate glycosaminoglycan biosynthesis in a mammalian cell line. Chembiochem 2008 Jan 25;9(2):198-200