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Aaron L. Fogelson
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Phone: 801-581-8150
Office: 312 LCB

Aaron L. Fogelson

Professor of Mathematics
Adjunct Professor, Bioengineering
BA Wesleyan University Mathematics
PhD New York University Mathematics

Research

Modeling in physiological fluid dynamics. Interaction of physical processes (flow, mechanics) with biochemistry in physiological systems.


Current Research

Modeling of many aspects of blood clot formation and dissolution including platelet aggregation, coagulation enzyme biochemistry, fibrin gel formation, and fibrin lysis.


Selected Publications

Walton BL, Lehmann M, Skorczewski T, Holle LA, Beckman JD, Cribb JA, Mooberry MJ, Wufsus AR, Cooley BC, Homeister JW, Pawlinski R, Falvo MR, Key NS, Fogelson AL, Neeves KB, Wolberg AS, Elevated hematocrit enhances platelet accumulation following vascular injury. Blood 2017 Mar 1;:

Elizondo P, Fogelson AL, A Mathematical Model of Venous Thrombosis Initiation. Biophys J 2016 Dec 20;111(12):2722-2734

Leiderman K, Chang WC, Ovanesov M, Fogelson AL, Synergy Between Tissue Factor and Exogenous Factor XIa in Initiating Coagulation. Arterioscler Thromb Vasc Biol 2016 Dec;36(12):2334-2345

Eichinger CD, Fogelson AL, Hlady V, Functional assay of antiplatelet drugs based on margination of platelets in flowing blood. Biointerphases 2016 Jun 30;11(2):029805

Shankar V, Wright GB, Kirby RM, Fogelson AL, A Radial Basis Function (RBF)-Finite Difference (FD) Method for Diffusion and Reaction-Diffusion Equations on Surfaces. J Sci Comput 2016 Jun 1;63(3):745-768

Fogelson AL, Neeves KB, Fluid Mechanics of Blood Clot Formation. Annu Rev Fluid Mech 2015 Jan 1;47:377-403

Du J, Guy RD, Fogelson AL, An Immersed Boundary Method for Two-fluid Mixtures. J Comput Phys 2014 Apr 1;262:231-243

Skorczewski T, Erickson LC, Fogelson AL, Platelet motion near a vessel wall or thrombus surface in two-dimensional whole blood simulations. Biophys J 2013 Apr 16;104(8):1764-72

Shankar V, Wright GB, Fogelson AL, Kirby RM, A study of different modeling choices for simulating platelets within the immersed boundary method. Appl Numer Math 2013 Jan;63:58-77

Sircar S, Keener JP, Fogelson AL, The effect of divalent vs. monovalent ions on the swelling of mucin-like polyelectrolyte gels: governing equations and equilibrium analysis. J Chem Phys 2013 Jan 7;138(1):014901

Du J, Keener JP, Guy RD, Fogelson AL, Low-Reynolds-number swimming in viscous two-phase fluids. Phys Rev E Stat Nonlin Soft Matter Phys 2012 Mar;85(3-2):036304

Du J, Keener JP, Guy RD, Fogelson AL, Low-Reynolds-number swimming in viscous two-phase fluids. Phys Rev E Stat Nonlin Soft Matter Phys 2012 Mar;85(3 Pt 2):036304

Fogelson AL, Hussain YH, Leiderman K, Blood clot formation under flow: the importance of factor XI depends strongly on platelet count. Biophys J 2012 Jan 4;102(1):10-8

Keener JP, Sircar S, Fogelson AL, Influence of the standard free energy on swelling kinetics of gels. Phys Rev E Stat Nonlin Soft Matter Phys 2011 Apr;83(4 Pt 1):041802

Leiderman K, Fogelson AL, Grow with the flow: a spatial-temporal model of platelet deposition and blood coagulation under flow. Math Med Biol 2011 Mar;28(1):47-84

Fogelson AL, Keener JP, Toward an understanding of fibrin branching structure. Phys Rev E Stat Nonlin Soft Matter Phys 2010 May;81(5 Pt 1):051922

Crowl LM, Fogelson AL, Computational model of whole blood exhibiting lateral platelet motion induced by red blood cells. Int j numer method biomed eng 2010 Mar 1;26(3-4):471-487

Leiderman KM, Miller LA, Fogelson AL, The effects of spatial inhomogeneities on flow through the endothelial surface layer. J Theor Biol 2008 May 21;252(2):313-25

Guy RD, Fogelson AL, Keener JP, Fibrin gel formation in a shear flow. Math Med Biol 2007 Mar;24(1):111-30

Fogelson AL, Tania N, Coagulation under flow: the influence of flow-mediated transport on the initiation and inhibition of coagulation. Pathophysiol Haemost Thromb 2005;34(2-3):91-108

Fogelson AL, Guy RD, Platelet-wall interactions in continuum models of platelet thrombosis: formulation and numerical solution. Math Med Biol 2004 Dec;21(4):293-334

Yi CS, Fogelson AL, Keener JP, Peskin CS, A mathematical study of volume shifts and ionic concentration changes during ischemia and hypoxia. J Theor Biol 2003 Jan 7;220(1):83-106

Guy RD, Fogelson AL, Probabilistic modeling of platelet aggregation: effects of activation time and receptor occupancy. J Theor Biol 2002 Nov 7;219(1):33-53

Fogelson AL, Kuharsky AL, Membrane binding-site density can modulate activation thresholds in enzyme systems. J Theor Biol 1998 Jul 7;193(1):1-18

Fogelson AL, Wang NT, Platelet dense-granule centralization and the persistence of ADP secretion. Am J Physiol 1996 Mar;270(3 Pt 2):H1131-40