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Joel  Harris
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Phone: 801-581-3585
Office: 182 HEB

Joel Harris

Distinguished Professor of Chemistry
Adjunct Professor, Bioengineering



Selected Publications

Kitt JP, Bryce DA, Minteer SD, Harris JM, Raman Spectroscopy Reveals Selective Interactions of Cytochrome c with Cardiolipin That Correlate with Membrane Permeability. J Am Chem Soc 2017 Mar 7;:

Bryce DA, Kitt JP, Harris JM, Confocal Raman Microscopy Investigation of Molecular Transport into Individual Chromatographic Silica Particles. Anal Chem 2017 Mar 7;89(5):2755-2763

Uddin MI, Islam S, Nishat NS, Hossain M, Rafique TA, Rashu R, Hoq MR, Zhang Y, Saha A, Harris JB, Calderwood SB, Bhuiyan TR, Ryan ET, Leung DT, Qadri F, Biomarkers of Environmental Enteropathy are Positively Associated with Immune Responses to an Oral Cholera Vaccine in Bangladeshi Children. PLoS Negl Trop Dis 2016 Nov 8;10(11):e0005039

Kitt JP, Harris JM, Confocal Raman Microscopy of Hybrid-Supported Phospholipid Bilayers within Individual C18-Functionalized Chromatographic Particles. Langmuir 2016 Sep 6;32(35):9033-44

Kitt JP, Bryce DA, Harris JM, Calorimetry-Derived Composition Vectors to Resolve Component Raman Spectra in Phospholipid Phase Transitions. Appl Spectrosc 2016 Jul;70(7):1165-75

Peterson EM, Manhart MW, Harris JM, Competitive Assays of Label-Free DNA Hybridization with Single-Molecule Fluorescence Imaging Detection. Anal Chem 2016 Jun 21;88(12):6410-7

Cooper JT, Harris JM, Spatially Multiplexed Imaging: Fluorescence Correlation Spectroscopy for Efficient Measurement of Molecular Diffusion at Solid-Liquid Interfaces. Appl Spectrosc 2016 Apr;70(4):695-701

Peterson EM, Manhart MW, Harris JM, Single-Molecule Fluorescence Imaging of Interfacial DNA Hybridization Kinetics at Selective Capture Surfaces. Anal Chem 2016 Jan 19;88(2):1345-54

Hardcastle CD, Harris JM, Confocal Raman Microscopy for pH-Gradient Preconcentration and Quantitative Analyte Detection in Optically Trapped Phospholipid Vesicles. Anal Chem 2015 Aug 4;87(15):7979-86

Hartley JM, Chu TW, Peterson EM, Zhang R, Yang J, Harris J, Kopecek J, Super-Resolution Imaging and Quantitative Analysis of Membrane Protein/Lipid Raft Clustering Mediated by Cell-Surface Self-Assembly of Hybrid Nanoconjugates. Chembiochem 2015 Aug 17;16(12):1725-9

Kitt JP, Harris JM, Confocal Raman Microscopy for in Situ Measurement of Octanol-Water Partitioning within the Pores of Individual C18-Functionalized Chromatographic Particles. Anal Chem 2015 May 19;87(10):5340-7

Kitt JP, Bryce DA, Harris JM, Spatial filtering of a diode laser beam for confocal Raman microscopy. Appl Spectrosc 2015 Apr;69(4):513-7

Cooper J, Harris JM, Fluorescence-correlation spectroscopy study of molecular transport within reversed-phase chromatographic particles compared to planar model surfaces. Anal Chem 2014 Dec 2;86(23):11766-72

Elliott LC, Barhoum M, Harris JM, Bohn PW, Correction: Trajectory analysis of single molecules exhibiting non-Brownian motion. Phys Chem Chem Phys 2014 Oct 28;16(40):22427

Elliott LC, Barhoum M, Harris JM, Bohn PW, Correction: Trajectory analysis of single molecules exhibiting non-Brownian motion. Phys Chem Chem Phys 2014 Sep 24;16(40):22427

Cooper JT, Harris JM, Imaging fluorescence-correlation spectroscopy for measuring fast surface diffusion at liquid/solid interfaces. Anal Chem 2014 Aug 5;86(15):7618-26

Kitt JP, Harris JM, Confocal Raman microscopy for in situ detection of solid-phase extraction of pyrene into single C18-silica particles. Anal Chem 2014 Feb 4;86(3):1719-25

Harris JP, Manship DR, Breckenridge WH, Wright TG, Comparison of the interactions in the rare gas hydride and Group 2 metal hydride anions. J Chem Phys 2014 Feb 28;140(8):084304

Schaefer JJ, Crawford AC, Porter MD, Harris JM, Confocal Raman microscopy for investigating synthesis and characterization of individual optically trapped vinyl-polymerized surfactant particles. Appl Spectrosc 2014;68(6):633-41

Cooper JT, Peterson EM, Harris JM, Fluorescence imaging of single-molecule retention trajectories in reversed-phase chromatographic particles. Anal Chem 2013 Oct 1;85(19):9363-70

Peterson EM, Harris JM, Imaging fluorescent nanoparticles to probe photoinduced charging of a semiconductor-solution interface. Langmuir 2013 Sep 24;29(38):11941-9

Ma C, Harris JM, Surface-enhanced Raman spectroscopy detection of ionic solutes by surfactant-mediated adsorption to a hydrophobic surface. Appl Spectrosc 2013 Jul;67(7):801-7

Peterson EM, Harris JM, Single-molecule fluorescence imaging of DNA at a potential-controlled interface. Langmuir 2013 Jul 2;29(26):8292-301

Myers GA, Gacek DA, Peterson EM, Fox CB, Harris JM, Microscopic rates of peptide-phospholipid bilayer interactions from single-molecule residence times. J Am Chem Soc 2012 Dec 5;134(48):19652-60

Schaefer JJ, Ma C, Harris JM, Confocal Raman microscopy probing of temperature-controlled release from individual, optically-trapped phospholipid vesicles. Anal Chem 2012 Nov 6;84(21):9505-12

Ma C, Harris JM, Surface-enhanced Raman scattering study of the kinetics of self-assembly of carboxylate-terminated n-alkanethiols on silver. Langmuir 2012 Feb 7;28(5):2628-36

Heider EC, Myers GA, Harris JM, Spectroscopic microscopy analysis of the interior pH of individual phospholipid vesicles. Anal Chem 2011 Nov 1;83(21):8230-8

Myers GA, Harris JM, Confocal Raman microscopy of pH-gradient-based 10?000-fold preconcentration of compounds within individual, optically trapped phospholipid vesicles. Anal Chem 2011 Aug 1;83(15):6098-105

Heider EC, Peterson EM, Barhoum M, Gericke KH, Harris JM, Quantitative fluorescence microscopy to determine molecular occupancy of phospholipid vesicles. Anal Chem 2011 Jul 1;83(13):5128-36

Heider EC, Barhoum M, Edwards K, Gericke KH, Harris JM, Structural characterization of individual vesicles using fluorescence microscopy. Anal Chem 2011 Jun 15;83(12):4909-15

Schibel AE, Heider EC, Harris JM, White HS, Fluorescence microscopy of the pressure-dependent structure of lipid bilayers suspended across conical nanopores. J Am Chem Soc 2011 May 25;133(20):7810-5

Ma C, Harris JM, Surface-enhanced Raman spectroscopy investigation of the potential-dependent acid-base chemistry of silver-immobilized 2-mercaptobenzoic acid. Langmuir 2011 Apr 5;27(7):3527-33

Elliott LC, Barhoum M, Harris JM, Bohn PW, Trajectory analysis of single molecules exhibiting non-Brownian motion. Phys Chem Chem Phys 2011 Mar 14;13(10):4326-34

Gasser-Ramirez JL, Harris JM, Quantitative confocal Raman microscopy study of ion-interaction retention at reversed-phase chromatographic interfaces. Anal Chem 2010 Jul 1;82(13):5743-50

Cherney DP, Harris JM, Confocal Raman microscopy of optical-trapped particles in liquids. Annu Rev Anal Chem (Palo Alto Calif) 2010;3:277-97

Peterson EM, Harris JM, Quantitative detection of single molecules in fluorescence microscopy images. Anal Chem 2010 Jan 1;82(1):189-96

Heider EC, Barhoum M, Peterson EM, Schaefer J, Harris JM, Identification of single fluorescent labels using spectroscopic microscopy. Appl Spectrosc 2010 Jan;64(1):37-45

Gasser-Ramirez JL, Harris JM, Confocal Raman microscopy investigation of the wetting of reversed-phase liquid chromatographic stationary phase particles. Anal Chem 2009 Sep 15;81(18):7632-8

Maran U, Britt D, Fox CB, Harris JM, Orendt AM, Conley H, Davis R, Hlady V, Stang PJ, Self-assembly of a triangle-shaped, hexaplatinum-incorporated, supramolecular amphiphile in solution and at interfaces. Chemistry 2009 Aug 24;15(34):8566-77

Fox CB, Wayment JR, Myers GA, Endicott SK, Harris JM, Single-molecule fluorescence imaging of peptide binding to supported lipid bilayers. Anal Chem 2009 Jul 1;81(13):5130-8

Gasser-Ramirez JL, Harris JM, Confocal Raman microscopy of the interfacial regions of liquid chromatographic stationary-phase materials. Anal Chem 2009 Apr 15;81(8):2869-76

Wayment JR, Harris JM, Biotin-avidin binding kinetics measured by single-molecule imaging. Anal Chem 2009 Jan 1;81(1):336-42

Oklejas V, Uibel RH, Horton R, Harris JM, Electric-field control of the tautomerization and metal ion binding reactivity of 8-hydroxyquinoline immobilized to an electrode surface. Anal Chem 2008 Mar 15;80(6):1891-901

Olson LG, Harris JM, Surface-enhanced Raman spectroscopy studies of surfactant adsorption to a hydrophobic interface. Appl Spectrosc 2008 Feb;62(2):149-56

Fox CB, Uibel RH, Harris JM, Detecting phase transitions in phosphatidylcholine vesicles by Raman microscopy and self-modeling curve resolution. J Phys Chem B 2007 Oct 4;111(39):11428-36

Fox CB, Myers GA, Harris JM, Temperature-controlled confocal Raman microscopy to detect phase transitions in phospholipid vesicles. Appl Spectrosc 2007 May;61(5):465-9

Wayment JR, Harris JM, Controlling binding site densities on glass surfaces. Anal Chem 2006 Nov 15;78(22):7841-9

Cherney DP, Myers GA, Horton RA, Harris JM, Optically trapping confocal Raman microscopy of individual lipid vesicles: kinetics of phospholipase A(2)-catalyzed hydrolysis of phospholipids in the membrane bilayer. Anal Chem 2006 Oct 1;78(19):6928-35

Fox CB, Horton RA, Harris JM, Detection of drug-membrane interactions in individual phospholipid vesicles by confocal Raman microscopy. Anal Chem 2006 Jul 15;78(14):4918-24

Wang G, Zhang B, Wayment JR, Harris JM, White HS, Electrostatic-gated transport in chemically modified glass nanopore electrodes. J Am Chem Soc 2006 Jun 14;128(23):7679-86

Bridges TE, Uibel RH, Harris JM, Measuring diffusion of molecules into individual polymer particles by confocal Raman microscopy. Anal Chem 2006 Apr 1;78(7):2121-9

Uibel RH, Harris JM, Templating of multiple ligand metal ion complexation sites in 8-hydroxyquinoline-modified silica sol-gel materials investigated by in situ Raman spectroscopy. Anal Chem 2005 Feb 15;77(4):991-1000

Olson LG, Uibel RH, Harris JM, C18-modified metal-colloid substrates for surface-enhanced Raman detection of trace-level polycyclic aromatic hydrocarbons in aqueous solution. Appl Spectrosc 2004 Dec;58(12):1394-400

Cherney DP, Bridges TE, Harris JM, Optical trapping of unilamellar phospholipid vesicles: investigation of the effect of optical forces on the lipid membrane shape by confocal-Raman microscopy. Anal Chem 2004 Sep 1;76(17):4920-8

Uibel RH, Harris JM, Resolution of intermediate adsorbate structures in the potential-dependent self-assembly of n-hexanethiolate on Silver by in situ surface-enhanced Raman spectroscopy. Appl Spectrosc 2004 Aug;58(8):934-44

Oklejas V, Harris JM, Potential-dependent surface-enhanced Raman scattering from adsorbed thiocyanate for characterizing silver surfaces with improved reproducibility. Appl Spectrosc 2004 Aug;58(8):945-51

Bridges TE, Houlne MP, Harris JM, Spatially resolved analysis of small particles by confocal Raman microscopy: depth profiling and optical trapping. Anal Chem 2004 Feb 1;76(3):576-84

McCain KS, Schluesche P, Harris JM, Modifying the adsorption behavior of polyamidoamine dendrimers at silica surfaces investigated by total internal reflection fluorescence correlation spectroscopy. Anal Chem 2004 Feb 15;76(4):930-8

McCain KS, Schluesche P, Harris JM, Poly(amidoamine) dendrimers as nanoscale diffusion probes in sol-gel films investigated by total internal reflection fluorescence spectroscopy. Anal Chem 2004 Feb 15;76(4):939-46

Cherney DP, Conboy JC, Harris JM, Optical-trapping Raman microscopy detection of single unilamellar lipid vesicles. Anal Chem 2003 Dec 1;75(23):6621-8

McCain KS, Hanley DC, Harris JM, Single-molecule fluorescence trajectories for investigating molecular transport in thin silica sol-gel films. Anal Chem 2003 Sep 1;75(17):4351-9

McCain KS, Harris JM, Total internal reflection fluorescence-correlation spectroscopy study of molecular transport in thin sol-gel films. Anal Chem 2003 Jul 15;75(14):3616-24

Kleimeyer JA, Harris JM, Monitoring the formation and decay of transient photosensitized intermediates using pump-probe UV resonance Raman spectroscopy. II: Kinetic modeling and multidimensional least-squares analysis. Appl Spectrosc 2003 Apr;57(4):448-53

Kleimeyer JA, Harris JM, Monitoring the formation and decay of transient photosensitized intermediates using pump-probe UV resonance Raman spectroscopy. I: Self-modeling curve resolution. Appl Spectrosc 2003 Apr;57(4):439-47

Houlne MP, Sjostrom CM, Uibel RH, Kleimeyer JA, Harris JM, Confocal Raman microscopy for monitoring chemical reactions on single optically trapped, solid-phase support particles. Anal Chem 2002 Sep 1;74(17):4311-9

Shield SR, Harris JM, Triplet-state photoexcitation dipole-jump relaxation method to observe adsorption/desorption kinetics at a reversed-phase silica/solution interface. Anal Chem 2002 May 15;74(10):2248-56

Oklejas V, Sjostrom C, Harris JM, SERS detection of the vibrational Stark effect from nitrile-terminated SAMs to probe electric fields in the diffuse double-layer. J Am Chem Soc 2002 Mar 20;124(11):2408-9

Hanley DC, Harris JM, Quantitative dosing of surfaces with fluorescent molecules: characterization of fractional monolayer coverages by counting single molecules. Anal Chem 2001 Nov 1;73(21):5030-7

Olson LG, Lo YS, Beebe TP Jr, Harris JM, Characterization of silane-modified immobilized gold colloids as a substrate for surface-enhanced Raman spectroscopy. Anal Chem 2001 Sep 1;73(17):4268-76

Rivera D, Harris JM, In situ ATR-FT-IR kinetic studies of molecular transport and surface binding in thin sol-gel films: reactions of chlorosilane reagents in porous silica materials. Anal Chem 2001 Feb 1;73(3):411-23

Rivera D, Poston PE, Uibel RH, Harris JM, In situ adsorption studies at silica/solution interfaces by attenuated total internal reflection fourier transform infrared spectroscopy: examination of adsorption models in normal-phase liquid chromatography Anal Chem 2000 Apr 1;72(7):1543-54

Lacy WB, Olson LG, Harris JM, Quantitative SERS Measurements on Dielectric-Overcoated Silver-Island Films by Solution-Deposition Control of Surface Concentrations. Anal Chem 1999 Jul 1;71(13):2564-70

Shield SR, Harris JM, Time-resolved fluorescence monitoring of aromatic radicals in photoinitiated processes. Anal Chem 1998 Jul 1;70(13):2576-83

Hansen RL, Harris JM, Total internal reflection fluorescence correlation spectroscopy for counting molecules at solid/liquid interfaces. Anal Chem 1998 Jul 1;70(13):2565-75

Hansen RL, Zhu XR, Harris JM, Fluorescence correlation spectroscopy with patterned photoexcitation for measuring solution diffusion coefficients of robust fluorophores. Anal Chem 1998 Apr 1;70(7):1281-7

Hansen RL, Harris JM, Lateral diffusion of molecules partitioned into silica-bound alkyl chains:? influence of chain length and bonding density. Anal Chem 1996 Sep 1;68(17):2879-84

Ren FY, Harris JM, Temperature-jump investigation of alkyl chain length effects on sorption/desorption kinetics at reversed-phase chromatographic interfaces. Anal Chem 1996 May 1;68(9):1651-7

Hansen RL, Harris JM, Lateral diffusion of molecules partitioned into C-18 ligands on silica surfaces. Anal Chem 1995 Feb 1;67(3):492-8

Karger AE, Harris JM, Gesteland RF, Multiwavelength fluorescence detection for DNA sequencing using capillary electrophoresis. Nucleic Acids Res 1991 Sep 25;19(18):4955-62

Dorsey CC, Pelletier MJ, Harris JM, Time correlation method for measuring fluorescence decays with a cw laser. Rev Sci Instrum 1979 Mar;50(3):333