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Guido  Gerig
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Phone: 801 587 7875 (SCI admin)

Guido Gerig

Professor of Computer Science
Director Utah Center for Neuroimage Analysis (UCNIA, www.ucnia.org)
Associate Director, Scientific Computing and Imaging Institute (SCI)
Faculty Member, Utah Brain Institute
Adjunct Prof., Utah Dept. of Bioengineering
Adjunct Professor, Bioengineering
2010: Fellow of the American Institute for Medical and Biological Engineering (AIMBE)
2009: Fellow of the Medical Image Computing and Computer-Assisted Intervention (MICCAI) Society
Education:
M.Sc. 1981, Natural Sciences, Swiss Federal Institute of Technology, ETH Zurich, Switzerland
Ph.D. 1987, EE and Computer Science, ETH Zurich, Switzerland
Venia Legendi (Habilitation), 1993, EE and Computer Science, ETH Zurich, Switzerland

Research

Image Processing, Computer Vision, Medical Image Analysis


Current Research

Guido Gerig supports a number of clinical neuroimaging projects with methodology for image processing, registration, atlas building, segmentation, shape analysis, and statistical analysis. Driving clinical problems are brain imaging studies in children with autism, infants at risk for schizophrenia, and the study of early development from birth to 5 years. Current key research topics are segmentation of MRI/DTI of the early developing brain, longitudinal analysis of multi-shape complexes, building of population atlases of volumetric images and embedded shapes, and new methodologies for statistical analysis of diffusion tensor imaging (DTI). Tools and methods developed through driving clinical applications are open source (ITK) and made available to public (http://www.ia.unc.edu/dev).
Main grant participations are Down syndrome: Bridging Genes, Brain and Cognition (NICHD, J. Korenberg USTAR), NAMIC (U54 roadmap National Alliance of Medical Image Computing), UNC-CONTE (Silvio Conte Center for Pathophysiology of Schizophrenia), ACE (Autism Centers of Excellence, IBIS), UNC-BRP (Biological Research Partnership, Advanced Imaging of Infants) and Cocaine Use in Mother-Infant Dyads (UNC-Yale-Utah project, supported by NIDA).


Selected Publications

Swanson MR, Wolff JJ, Elison JT, Gu H, Hazlett HC, Botteron K, Styner M, Paterson S, Gerig G, Constantino J, Dager S, Estes A, Vachet C, Piven J, Splenium development and early spoken language in human infants. Dev Sci 2017 Mar;20(2):

Wolff JJ, Swanson MR, Elison JT, Gerig G, Pruett JR Jr, Styner MA, Vachet C, Botteron KN, Dager SR, Estes AM, Hazlett HC, Schultz RT, Shen MD, Zwaigenbaum L, Piven J, Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism. Mol Autism 2017;8:8

Wang B, Prastawa M, Irimia A, Saha A, Liu W, Goh SY, Vespa PM, Van Horn JD, Gerig G, Modeling 4D Pathological Changes by Leveraging Normative Models. Comput Vis Image Underst 2016 Oct;151:3-13

Kim SH, Lyu I, Fonov VS, Vachet C, Hazlett HC, Smith RG, Piven J, Dager SR, Mckinstry RC, Pruett JR Jr, Evans AC, Collins DL, Botteron KN, Schultz RT, Gerig G, Styner MA, Development of cortical shape in the human brain from 6 to 24months of age via a novel measure of shape complexity. Neuroimage 2016 Jul 15;135:163-76

Muralidharan P, Fishbaugh J, Kim EY, Johnson HJ, Paulsen JS, Gerig G, Fletcher PT, Bayesian Covariate Selection in Mixed-Effects Models For Longitudinal Shape Analysis. Proc IEEE Int Symp Biomed Imaging 2016 Apr;2016:656-659

Conlin CC, Zhang JL, Rousset F, Vachet C, Zhao Y, Morton KA, Carlston K, Gerig G, Lee VS, Performance of an efficient image-registration algorithm in processing MR renography data. J Magn Reson Imaging 2016 Feb;43(2):391-7

Pujol S, Wells W, Pierpaoli C, Brun C, Gee J, Cheng G, Vemuri B, Commowick O, Prima S, Stamm A, Goubran M, Khan A, Peters T, Neher P, Maier-Hein KH, Shi Y, Tristan-Vega A, Veni G, Whitaker R, Styner M, Westin CF, Gouttard S, Norton I, Chauvin L, Mamata H,, The DTI Challenge: Toward Standardized Evaluation of Diffusion Tensor Imaging Tractography for Neurosurgery. J Neuroimaging 2015 Nov-Dec;25(6):875-82

Rutherford HJ, Gerig G, Gouttard S, Potenza MN, Mayes LC, Investigating Maternal Brain Structure and its Relationship to Substance Use and Motivational Systems. Yale J Biol Med 2015 Sep;88(3):211-7

Wolff JJ, Gerig G, Lewis JD, Soda T, Styner MA, Vachet C, Botteron KN, Elison JT, Dager SR, Estes AM, Hazlett HC, Schultz RT, Zwaigenbaum L, Piven J, Altered corpus callosum morphology associated with autism over the first 2 years of life. Brain 2015 Jul;138(Pt 7):2046-58

Kim SH, Fonov V, Collins DL, Gerig G, Styner MA, Shape index distribution based local surface complexity applied to the human cortex. Proc SPIE Int Soc Opt Eng 2015;9413:

Pruett JR Jr, Kandala S, Hoertel S, Snyder AZ, Elison JT, Nishino T, Feczko E, Dosenbach NU, Nardos B, Power JD, Adeyemo B, Botteron KN, McKinstry RC, Evans AC, Hazlett HC, Dager SR, Paterson S, Schultz RT, Collins DL, Fonov VS, Styner M, Gerig G, Das S, , Accurate age classification of 6 and 12 month-old infants based on resting-state functional connectivity magnetic resonance imaging data. Dev Cogn Neurosci 2015 Apr;12:123-33

Salzwedel AP, Grewen KM, Vachet C, Gerig G, Lin W, Gao W, Prenatal drug exposure affects neonatal brain functional connectivity. J Neurosci 2015 Apr 8;35(14):5860-9

Cherel M, Budin F, Prastawa M, Gerig G, Lee K, Buss C, Lyall A, Consing KZ, Styner M, Automatic Tissue Segmentation of Neonate Brain MR Images with Subject-specific Atlases. Proc SPIE Int Soc Opt Eng 2015 Feb 21;9413:

Fishbaugh J, Prastawa M, Gerig G, Durrleman S, Geodesic image regression with a sparse parameterization of diffeomorphisms. Geom Sci Inf (2013) 2013;8085:95-102

Anderson JS, Treiman SM, Ferguson MA, Nielsen JA, Edgin JO, Dai L, Gerig G, Korenberg JR, Violence: heightened brain attentional network response is selectively muted in Down syndrome. J Neurodev Disord 2015;7(1):15

Grewen K, Burchinal M, Vachet C, Gouttard S, Gilmore JH, Lin W, Johns J, Elam M, Gerig G, Prenatal cocaine effects on brain structure in early infancy. Neuroimage 2014 Nov 1;101:114-23

Durrleman S, Prastawa M, Charon N, Korenberg JR, Joshi S, Gerig G, Trouvé A, Morphometry of anatomical shape complexes with dense deformations and sparse parameters. Neuroimage 2014 Nov 1;101:35-49

Lewis JD, Evans AC, Pruett JR, Botteron K, Zwaigenbaum L, Estes A, Gerig G, Collins L, Kostopoulos P, McKinstry R, Dager S, Paterson S, Schultz RT, Styner M, Hazlett H, Piven J, Network inefficiencies in autism spectrum disorder at 24 months. Transl Psychiatry 2014 May 6;4:e388

Fishbaugh J, Prastawa M, Gerig G, Durrleman S, GEODESIC REGRESSION OF IMAGE AND SHAPE DATA FOR IMPROVED MODELING OF 4D TRAJECTORIES. Proc IEEE Int Symp Biomed Imaging 2014 Apr;2014:385-388

Gao Y, Prastawa M, Styner M, Piven J, Gerig G, A JOINT FRAMEWORK FOR 4D SEGMENTATION AND ESTIMATION OF SMOOTH TEMPORAL APPEARANCE CHANGES. Proc IEEE Int Symp Biomed Imaging 2014 Apr;2014:1291-1294

Sharma A, Fletcher PT, Gilmore JH, Escolar ML, Gupta A, Styner M, Gerig G, PARAMETRIC REGRESSION SCHEME FOR DISTRIBUTIONS: ANALYSIS OF DTI FIBER TRACT DIFFUSION CHANGES IN EARLY BRAIN DEVELOPMENT. Proc IEEE Int Symp Biomed Imaging 2014 Apr;2014:559-562

Wang B, Liu W, Prastawa M, Irimia A, Vespa PM, van Horn JD, Fletcher PT, Gerig G, 4D ACTIVE CUT: AN INTERACTIVE TOOL FOR PATHOLOGICAL ANATOMY MODELING. Proc IEEE Int Symp Biomed Imaging 2014 Apr;2014:529-532

Vardhan A, Prastawa M, Vachet C, Piven J, Gerig G, Characterizing growth patterns in longitudinal MRI using image contrast. Proc SPIE Int Soc Opt Eng 2014 Mar 21;9034:90340D

Oguz I, Farzinfar M, Matsui J, Budin F, Liu Z, Gerig G, Johnson HJ, Styner M, DTIPrep: quality control of diffusion-weighted images. Front Neuroinform 2014;8:4

Wang J, Vachet C, Rumple A, Gouttard S, Ouziel C, Perrot E, Du G, Huang X, Gerig G, Styner M, Multi-atlas segmentation of subcortical brain structures via the AutoSeg software pipeline. Front Neuroinform 2014;8:7

Verde AR, Budin F, Berger JB, Gupta A, Farzinfar M, Kaiser A, Ahn M, Johnson H, Matsui J, Hazlett HC, Sharma A, Goodlett C, Shi Y, Gouttard S, Vachet C, Piven J, Zhu H, Gerig G, Styner M, UNC-Utah NA-MIC framework for DTI fiber tract analysis. Front Neuroinform 2014;7:51

Wang B, Prastawa M, Irimia A, Chambers MC, Sadeghi N, Vespa PM, van Horn JD, Gerig G, ANALYZING IMAGING BIOMARKERS FOR TRAUMATIC BRAIN INJURY USING 4D MODELING OF LONGITUDINAL MRI. Proc IEEE Int Symp Biomed Imaging 2013 Dec 31;2013:1392-1395

Vardhan A, Prastawa M, Sharma A, Piven J, Gerig G, MODELING LONGITUDINAL MRI CHANGES IN POPULATIONS USING A LOCALIZED, INFORMATION-THEORETIC MEASURE OF CONTRAST. Proc IEEE Int Symp Biomed Imaging 2013 Dec 31;2013:1396-1399

Sharma A, Durrleman S, Gilmore JH, Gerig G, LONGITUDINAL GROWTH MODELING OF DISCRETE-TIME FUNCTIONS WITH APPLICATION TO DTI TRACT EVOLUTION IN EARLY NEURODEVELOPMENT. Proc IEEE Int Symp Biomed Imaging 2013 Dec 31;2012:1945-1400

Sharma A, Fletcher PT, Gilmore JH, Escolar ML, Gupta A, Styner M, Gerig G, SPATIOTEMPORAL MODELING OF DISCRETE-TIME DISTRIBUTION-VALUED DATA APPLIED TO DTI TRACT EVOLUTION IN INFANT NEURODEVELOPMENT. Proc IEEE Int Symp Biomed Imaging 2013 Dec 31;2013:684-687

Cascio C, Gribbin M, Gouttard S, Smith RG, Jomier M, Field S, Graves M, Hazlett HC, Muller K, Gerig G, Piven J, Fractional anisotropy distributions in 2- to 6-year-old children with autism. J Intellect Disabil Res 2013 Nov;57(11):1037-49

Elison JT, Paterson SJ, Wolff JJ, Reznick JS, Sasson NJ, Gu H, Botteron KN, Dager SR, Estes AM, Evans AC, Gerig G, Hazlett HC, Schultz RT, Styner M, Zwaigenbaum L, Piven J, White matter microstructure and atypical visual orienting in 7-month-olds at risk for autism. Am J Psychiatry 2013 Aug 1;170(8):899-908

Farzinfar M, Oguz I, Smith RG, Verde AR, Dietrich C, Gupta A, Escolar ML, Piven J, Pujol S, Vachet C, Gouttard S, Gerig G, Dager S, McKinstry RC, Paterson S, Evans AC, Styner MA, Diffusion imaging quality control via entropy of principal direction distribution. Neuroimage 2013 May 17;82C:1-12

Elison JT, Wolff JJ, Heimer DC, Paterson SJ, Gu H, Hazlett HC, Styner M, Gerig G, Piven J, Frontolimbic neural circuitry at 6 months predicts individual differences in joint attention at 9 months. Dev Sci 2013 Mar;16(2):186-97

Paniagua B, Emodi O, Hill J, Fishbaugh J, Pimenta LA, Aylward SR, Andinet E, Gerig G, Gilmore J, van Aalst JA, Styner M, 3D of Brain Shape and Volume After Cranial Vault Remodeling Surgery for Craniosynostosis Correction in Infants. Proc SPIE Int Soc Opt Eng 2013 Mar 29;8672:86720V

Farzinfar M, Li Y, Verde AR, Oguz I, Gerig G, Styner MA, DTI Quality Control Assessment via Error Estimation From Monte Carlo Simulations. Proc Soc Photo Opt Instrum Eng 2013 Mar 13;8669:1667549

Verde AR, Berger JB, Gupta A, Farzinfar M, Kaiser A, Chanon VW, Boettiger C, Goodlett C, Shi Y, Zhu H, Gerig G, Gouttard S, Vachet C, Styner M, UNC-Utah NA-MIC DTI framework: Atlas Based Fiber Tract Analysis with Application to a Study of Nicotine Smoking Addiction. Proc SPIE Int Soc Opt Eng 2013 Mar 13;8669:

Sadeghi N, Prastawa M, Fletcher PT, Wolff J, Gilmore JH, Gerig G, Regional characterization of longitudinal DT-MRI to study white matter maturation of the early developing brain. Neuroimage 2013 Mar;68:236-47

Wang B, Prastawa M, Saha A, Awate SP, Irimia A, Chambers MC, Vespa PM, Van Horn JD, Pascucci V, Gerig G, Modeling 4D Changes in Pathological Anatomy using Domain Adaptation: Analysis of TBI Imaging using a Tumor Database. Multimodal Brain Image Anal (2013) 2013;8159:31-39

Short SJ, Elison JT, Goldman BD, Styner M, Gu H, Connelly M, Maltbie E, Woolson S, Lin W, Gerig G, Reznick JS, Gilmore JH, Associations between white matter microstructure and infants' working memory. Neuroimage 2013 Jan 1;64:156-66

Sadeghi N, Prastawa M, Fletcher PT, Vachet C, Wang B, Gilmore J, Gerig G, MULTIVARIATE MODELING OF LONGITUDINAL MRI IN EARLY BRAIN DEVELOPMENT WITH CONFIDENCE MEASURES. Proc IEEE Int Symp Biomed Imaging 2013;:1400-1403

McClure RK, Styner M, Maltbie E, Lieberman JA, Gouttard S, Gerig G, Shi X, Zhu H, Localized differences in caudate and hippocampal shape are associated with schizophrenia but not antipsychotic type. Psychiatry Res 2013 Jan 30;211(1):1-10

Anderson JS, Nielsen JA, Ferguson MA, Burback MC, Cox ET, Dai L, Gerig G, Edgin JO, Korenberg JR, Abnormal brain synchrony in Down Syndrome. Neuroimage Clin 2013;2:703-15

Dougherty MK, Gu H, Bizzell J, Ramsey S, Gerig G, Perkins DO, Belger A, Differences in subcortical structures in young adolescents at familial risk for schizophrenia: A preliminary study. Psychiatry Res 2012 Nov 9;:

Datar M, Muralidharan P, Kumar A, Gouttard S, Piven J, Gerig G, Whitaker R, Fletcher PT, Mixed-Effects Shape Models for Estimating Longitudinal Changes in Anatomy. Spatiotemporal Image Anal Longitud Time Ser Image Data (2012) 2012 Oct;7570:76-87

Kim SH, Fonov V, Dietrich C, Vachet C, Hazlett HC, Smith RG, Graves M, Piven J, Gilmore JH, Collins DL, Gerig G, Styner M, Adaptive prior probability and spatial temporal intensity change estimation for segmentation of the one-year-old human brain. J Neurosci Methods 2012 Sep 29;212(1):43-55

Lyall AE, Woolson S, Wolfe HM, Goldman BD, Reznick JS, Hamer RM, Lin W, Styner M, Gerig G, Gilmore JH, Prenatal isolated mild ventriculomegaly is associated with persistent ventricle enlargement at ages 1 and 2. Early Hum Dev 2012 Aug;88(8):691-8

Geng X, Gouttard S, Sharma A, Gu H, Styner M, Lin W, Gerig G, Gilmore JH, Quantitative tract-based white matter development from birth to age 2years. Neuroimage 2012 Jul 2;61(3):542-57

Hazlett HC, Gu H, McKinstry RC, Shaw DW, Botteron KN, Dager SR, Styner M, Vachet C, Gerig G, Paterson SJ, Schultz RT, Estes AM, Evans AC, Piven J, Brain volume findings in 6-month-old infants at high familial risk for autism. Am J Psychiatry 2012 Jun;169(6):601-8

Wolff JJ, Gu H, Gerig G, Elison JT, Styner M, Gouttard S, Botteron KN, Dager SR, Dawson G, Estes AM, Evans AC, Hazlett HC, Kostopoulos P, McKinstry RC, Paterson SJ, Schultz RT, Zwaigenbaum L, Piven J, Differences in white matter fiber tract development present from 6 to 24 months in infants with autism. Am J Psychiatry 2012 Jun;169(6):589-600

Wang B, Prastawa M, Irimia A, Chambers MC, Vespa PM, Van Horn JD, Gerig G, A Patient-Specific Segmentation Framework for Longitudinal MR Images of Traumatic Brain Injury. Proc SPIE Int Soc Opt Eng 2012 Mar 23;8314:831402

Vachet C, Yvernault B, Bhatt K, Smith RG, Gerig G, Hazlett HC, Styner M, Automatic corpus callosum segmentation using a deformable active Fourier contour model. Proc SPIE Int Soc Opt Eng 2012 Mar 23;8317:

Gouttard S, Goodlett CB, Kubicki M, Gerig G, Measures for Validation of DTI Tractography. Proc SPIE Int Soc Opt Eng 2012 Feb 23;8314:

Fishbaugh J, Durrleman S, Piven J, Gerig G, A framework for longitudinal data analysis via shape regression. Proc SPIE Int Soc Opt Eng 2012 Feb 23;8314:

Fishbaugh J, Prastawa M, Durrleman S, Piven J, Gerig G, Analysis of longitudinal shape variability via subject specific growth modeling. Med Image Comput Comput Assist Interv 2012;15(Pt 1):731-8

Durrleman S, Prastawa M, Korenberg JR, Joshi S, Trouvé A, Gerig G, Topology preserving atlas construction from shape data without correspondence using sparse parameters. Med Image Comput Comput Assist Interv 2012;15(Pt 3):223-30

Vardhan A, Prastawa M, Gouttard S, Piven J, Gerig G, QUANTIFYING REGIONAL GROWTH PATTERNS THROUGH LONGITUDINAL ANALYSIS OF DISTANCES BETWEEN MULTIMODAL MR INTENSITY DISTRIBUTIONS. Proc IEEE Int Symp Biomed Imaging 2012;:1156-1159

Sadeghi N, Prastawa M, Fletcher PT, Gilmore JH, Lin W, Gerig G, STATISTICAL GROWTH MODELING OF LONGITUDINAL DT-MRI FOR REGIONAL CHARACTERIZATION OF EARLY BRAIN DEVELOPMENT. Proc IEEE Int Symp Biomed Imaging 2012;:1507-1510

Wang B, Prastawa M, Awate SP, Irimia A, Chambers MC, Vespa PM, van Horn JD, Gerig G, SEGMENTATION OF SERIAL MRI OF TBI PATIENTS USING PERSONALIZED ATLAS CONSTRUCTION AND TOPOLOGICAL CHANGE ESTIMATION. Proc IEEE Int Symp Biomed Imaging 2012;:1152-1155

Irimia A, Chambers MC, Torgerson CM, Filippou M, Hovda DA, Alger JR, Gerig G, Toga AW, Vespa PM, Kikinis R, Van Horn JD, Patient-tailored connectomics visualization for the assessment of white matter atrophy in traumatic brain injury. Front Neurol 2012 Feb 6;3:10

Irimia A, Chambers MC, Alger JR, Filippou M, Prastawa MW, Wang B, Hovda DA, Gerig G, Toga AW, Kikinis R, Vespa PM, Van Horn JD, Comparison of Acute and Chronic Traumatic Brain Injury Using Semi-Automatic Multimodal Segmentation of MR Volumes. J Neurotrauma 2011 Nov;28(11):2287-306

Zhu H, Kong L, Li R, Styner M, Gerig G, Lin W, Gilmore JH, FADTTS: functional analysis of diffusion tensor tract statistics. Neuroimage 2011 Jun 1;56(3):1412-25

Knickmeyer RC, Kang C, Woolson S, Smith JK, Hamer RM, Lin W, Gerig G, Styner M, Gilmore JH, Twin-singleton differences in neonatal brain structure. Twin Res Hum Genet 2011 Jun;14(3):268-76

Hazlett HC, Poe MD, Gerig G, Styner M, Chappell C, Smith RG, Vachet C, Piven J, Early brain overgrowth in autism associated with an increase in cortical surface area before age 2 years. Arch Gen Psychiatry 2011 May;68(5):467-76

Gerig G, Oguz I, Gouttard S, Lee J, An H, Lin W, McMurray M, Grewen K, Johns J, Styner MA, Synergy of image analysis for animal and human neuroimaging supports translational research on drug abuse. Front Psychiatry 2011;2:53

Fishbaugh J, Durrleman S, Gerig G, Estimation of smooth growth trajectories with controlled acceleration from time series shape data. Med Image Comput Comput Assist Interv 2011;14(Pt 2):401-8

Ha L, Prastawa M, Gerig G, Gilmore JH, Silva CT, Joshi S, Efficient Probabilistic and Geometric Anatomical Mapping Using Particle Mesh Approximation on GPUs. Int J Biomed Imaging 2011;2011:572187

Durrleman S, Prastawa M, Gerig G, Joshi S, Optimal data-driven sparse parameterization of diffeomorphisms for population analysis. Inf Process Med Imaging 2011;22:123-34

Wang Y, Gupta A, Liu Z, Zhang H, Escolar ML, Gilmore JH, Gouttard S, Fillard P, Maltbie E, Gerig G, Styner M, DTI registration in atlas based fiber analysis of infantile Krabbe disease. Neuroimage 2011 Jan 19;:

Rueckert D, Hawkes D, Gerig G, Yang GZ, Editorial. Med Image Anal 2010 Oct;14(5):631-2

Gilmore JH, Kang C, Evans DD, Wolfe HM, Smith JK, Lieberman JA, Lin W, Hamer RM, Styner M, Gerig G, Prenatal and neonatal brain structure and white matter maturation in children at high risk for schizophrenia. Am J Psychiatry 2010 Sep;167(9):1083-91

Shi F, Shen D, Yap PT, Fan Y, Cheng JZ, An H, Wald LL, Gerig G, Gilmore JH, Lin W, CENTS: Cortical enhanced neonatal tissue segmentation. Hum Brain Mapp 2010 Aug 5;:

Gilmore JH, Schmitt JE, Knickmeyer RC, Smith JK, Lin W, Styner M, Gerig G, Neale MC, Genetic and environmental contributions to neonatal brain structure: A twin study. Hum Brain Mapp 2010 Aug;31(8):1174-82

El-Sayed M, Steen RG, Poe MD, Bethea TC, Gerig G, Lieberman J, Sikich L, Brain volumes in psychotic youth with schizophrenia and mood disorders. J Psychiatry Neurosci 2010 Jul;35(4):229-36

Gorczowski K, Styner M, Jeong JY, Marron JS, Piven J, Hazlett HC, Pizer SM, Gerig G, Multi-object analysis of volume, pose, and shape using statistical discrimination. IEEE Trans Pattern Anal Mach Intell 2010 Apr;32(4):652-61

Marc C, Vachet C, Gerig G, Blocher J, Gilmore J, Styner M, Changes of MR and DTI appearance in early human brain development. Proc SPIE Int Soc Opt Eng 2010 Mar 12;7623:

Liu Z, Goodlett C, Gerig G, Styner M, Evaluation of DTI Property Maps as Basis of DTI Atlas Building. Proc SPIE Int Soc Opt Eng 2010 Mar 12;7623:

Sadeghi N, Prastawa M, Gilmore JH, Lin W, Gerig G, Towards Analysis of Growth Trajectory through Multi-modal Longitudinal MR Imaging. Proc SPIE Int Soc Opt Eng 2010 Mar 12;7623:

Liu Z, Wang Y, Gerig G, Gouttard S, Tao R, Fletcher T, Styner M, Quality Control of Diffusion Weighted Images. Proc SPIE Int Soc Opt Eng 2010 Mar 11;7628:

Prastawa M, Sadeghi N, Gilmore JH, Lin W, Gerig G, A NEW FRAMEWORK FOR ANALYZING WHITE MATTER MATURATION IN EARLY BRAIN DEVELOPMENT. Proc IEEE Int Symp Biomed Imaging 2010;:97-100

Ha L, Prastawa M, Gerig G, Gilmore JH, Silva CT, Joshi S, Image registration driven by combined probabilistic and geometric descriptors. Med Image Comput Comput Assist Interv 2010;13(Pt 2):602-9

Sadeghi N, Prastawa M, Gilmore JH, Lin W, Gerig G, Spatio-Temporal Analysis of Early Brain Development. Conf Rec Asilomar Conf Signals Syst Comput 2010;2010:777-781

Mosconi MW, Cody-Hazlett H, Poe MD, Gerig G, Gimpel-Smith R, Piven J, Longitudinal study of amygdala volume and joint attention in 2- to 4-year-old children with autism. Arch Gen Psychiatry 2009 May;66(5):509-16

Prastawa M, Bullitt E, Gerig G, Simulation of brain tumors in MR images for evaluation of segmentation efficacy. Med Image Anal 2009 Apr;13(2):297-311

Mukherjee N, Kang C, Wolfe HM, Hertzberg BS, Smith JK, Lin W, Gerig G, Hamer RM, Gilmore JH, Discordance of prenatal and neonatal brain development in twins. Early Hum Dev 2009 Mar;85(3):171-5

Goodlett CB, Fletcher PT, Gilmore JH, Gerig G, Group analysis of DTI fiber tract statistics with application to neurodevelopment. Neuroimage 2009 Mar;45(1 Suppl):S133-42

Hazlett HC, Poe MD, Lightbody AA, Gerig G, Macfall JR, Ross AK, Provenzale J, Martin A, Reiss AL, Piven J, Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism. J Neurodev Disord 2009 Mar 1;1(1):81-90

Zhang F, Hancock ER, Goodlett C, Gerig G, Probabilistic white matter fiber tracking using particle filtering and von Mises-Fisher sampling. Med Image Anal 2009 Feb;13(1):5-18

Shi F, Yap PT, Fan Y, Cheng JZ, Wald LL, Gerig G, Lin W, Shen D, Cortical Enhanced Tissue Segmentation of Neonatal Brain MR Images Acquired by a Dedicated Phased Array Coil. Proc IEEE Comput Soc Conf Comput Vis Pattern Recognit 2009;2009(5204348):39-45

Durrleman S, Pennec X, Trouvé A, Gerig G, Ayache N, Spatiotemporal atlas estimation for developmental delay detection in longitudinal datasets. Med Image Comput Comput Assist Interv 2009;12(Pt 1):297-304

Datar M, Cates J, Fletcher PT, Gouttard S, Gerig G, Whitaker R, Particle based shape regression of open surfaces with applications to developmental neuroimaging. Med Image Comput Comput Assist Interv 2009;12(Pt 2):167-74

Gouttard S, Prastawa M, Bullitt E, Lin W, Goodlett C, Gerig G, Constrained data decomposition and regression for analyzing healthy aging from fiber tract diffusion properties. Med Image Comput Comput Assist Interv 2009;12(Pt 1):321-8

Gilmore JH, Smith LC, Wolfe HM, Hertzberg BS, Smith JK, Chescheir NC, Evans DD, Kang C, Hamer RM, Lin W, Gerig G, Prenatal mild ventriculomegaly predicts abnormal development of the neonatal brain. Biol Psychiatry 2008 Dec 15;64(12):1069-76

Gao W, Lin W, Chen Y, Gerig G, Smith JK, Jewells V, Gilmore JH, Temporal and Spatial Development of Axonal Maturation and Myelination of White Matter in the Developing Brain. AJNR Am J Neuroradiol 2008 Nov 11;:

Knickmeyer RC, Gouttard S, Kang C, Evans D, Wilber K, Smith JK, Hamer RM, Lin W, Gerig G, Gilmore JH, A structural MRI study of human brain development from birth to 2 years. J Neurosci 2008 Nov 19;28(47):12176-82

Lin W, Zhu Q, Gao W, Chen Y, Toh CH, Styner M, Gerig G, Smith JK, Biswal B, Gilmore JH, Functional Connectivity MR Imaging Reveals Cortical Functional Connectivity in the Developing Brain. AJNR Am J Neuroradiol 2008 Sep 10;:

Gouttard S, Styner M, Prastawa M, Piven J, Gerig G, Assessment of reliability of multi-site neuroimaging via traveling phantom study. Med Image Comput Comput Assist Interv 2008;11(Pt 2):263-70

Goodlett CB, Fletcher PT, Gilmore JH, Gerig G, Group statistics of DTI fiber bundles using spatial functions of tensor measures. Med Image Comput Comput Assist Interv 2008;11(Pt 1):1068-75

Gilmore JH, Lin W, Corouge I, Vetsa YS, Smith JK, Kang C, Gu H, Hamer RM, Lieberman JA, Gerig G, Early postnatal development of corpus callosum and corticospinal white matter assessed with quantitative tractography. AJNR Am J Neuroradiol 2007 Oct;28(9):1789-95

Taylor WD, Macfall JR, Gerig G, Krishnan RR, Structural integrity of the uncinate fasciculus in geriatric depression: Relationship with age of onset. Neuropsychiatr Dis Treat 2007 Oct;3(5):669-74

Huang X, Lee YZ, McKeown M, Gerig G, Gu H, Lin W, Lewis MM, Ford S, Troster AI, Weinberger DR, Styner , Asymmetrical ventricular enlargement in Parkinson's disease. Mov Disord 2007 Aug 15;22(11):1657-60

Belmonte MK, Mazziotta JC, Minshew NJ, Evans AC, Courchesne E, Dager SR, Bookheimer SY, Aylward EH, Amaral DG, Cantor RM, Chugani DC, Dale AM, Davatzikos C, Gerig G, Herbert MR, Lainhart JE, Murphy DG, Piven J, Reiss AL, Schultz RT, Zeffiro TA, Levi-Pearl, Offering to Share: How to Put Heads Together in Autism Neuroimaging. J Autism Dev Disord 2007 Mar 9;:

Gilmore JH, Lin W, Prastawa MW, Looney CB, Vetsa YS, Knickmeyer RC, Evans DD, Smith JK, Hamer RM, Lieberman JA, Gerig , Regional gray matter growth, sexual dimorphism, and cerebral asymmetry in the neonatal brain. J Neurosci 2007 Feb 7;27(6):1255-60

Cascio CJ, Gerig G, Piven , Diffusion tensor imaging: Application to the study of the developing brain. J Am Acad Child Adolesc Psychiatry 2007 Feb;46(2):213-23

Zhang F, Goodlett C, Hancock E, Gerig G, Probabilistic fiber tracking using particle filtering. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 2007;10(Pt 2):144-52

Goodlett C, Fletcher PT, Lin W, Gerig G, Quantification of measurement error in DTI: theoretical predictions and validation. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 2007;10(Pt 1):10-7

Terriberry TB, Damon JN, Pizer SM, Joshi SC, Gerig , Population-based fitting of medial shape models with correspondence optimization. Inf Process Med Imaging 2007;20:700-12

Cascio C, Styner M, Smith RG, Poe MD, Gerig G, Hazlett HC, Jomier M, Bammer R, Piven , Reduced relationship to cortical white matter volume revealed by tractography-based segmentation of the corpus callosum in young children with developmental delay. Am J Psychiatry 2006 Dec;163(12):2157-63

Gilmore JH, Lin W, Gerig , Fetal and neonatal brain development. Am J Psychiatry 2006 Dec;163(12):2046

Corouge I, Fletcher PT, Joshi S, Gouttard S, Gerig , Fiber tract-oriented statistics for quantitative diffusion tensor MRI analysis. Med Image Anal 2006 Oct;10(5):786-98

Yushkevich PA, Piven J, Hazlett HC, Smith RG, Ho S, Gee JC, Gerig , User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. Neuroimage 2006 Jul 1;31(3):1116-28

Lorenzen P, Prastawa M, Davis B, Gerig G, Bullitt E, Joshi , Multi-modal image set registration and atlas formation. Med Image Anal 2006 Jun;10(3):440-51

Hazlett HC, Poe MD, Gerig G, Smith RG, Piven , Cortical gray and white brain tissue volume in adolescents and adults with autism. Biol Psychiatry 2006 Jan 1;59(1):1-6

Hoptman MJ, Volavka J, Czobor P, Gerig G, Chakos M, Blocher J, Citrome LL, Sheitman B, Lindenmayer JP, Lieberman JA, Bilder R , Aggression and quantitative MRI measures of caudate in patients with chronic schizophrenia or schizoaffective disorder. J Neuropsychiatry Clin Neurosci 2006 Fall;18(4):509-15

Goodlett C, Davis B, Jean R, Gilmore J, Gerig , Improved correspondence for DTI population studies via unbiased atlas building. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 2006;9(Pt 2):260-7

Hazlett HC, Poe M, Gerig G, Smith RG, Provenzale J, Ross A, Gilmore J, Piven , Magnetic resonance imaging and head circumference study of brain size in autism: birth through age 2 years. Arch Gen Psychiatry 2005 Dec;62(12):1366-76

Hoptman MJ, Volavka J, Weiss EM, Czobor P, Szeszko PR, Gerig G, Chakos M, Blocher J, Citrome LL, Lindenmayer JP, Sheitman B, Lieberman JA, Bilder R , Quantitative MRI measures of orbitofrontal cortex in patients with chronic schizophrenia or schizoaffective disorder. Psychiatry Res 2005 Nov 30;140(2):133-45

Pinkham A, Penn D, Wangelin B, Perkins D, Gerig G, Gu H, Lieberman , Facial emotion perception and fusiform gyrus volume in first episode schizophrenia. Schizophr Res 2005 Nov 15;79(2-3):341-3

Bullitt E, Zeng D, Gerig G, Aylward S, Joshi S, Smith JK, Lin W, Ewend M , Vessel tortuosity and brain tumor malignancy: a blinded study. Acad Radiol 2005 Oct;12(10):1232-40

Prastawa M, Gilmore JH, Lin W, Gerig , Automatic segmentation of MR images of the developing newborn brain. Med Image Anal 2005 Oct;9(5):457-66

Cevidanes LH, Franco AA, Gerig G, Proffit WR, Slice DE, Enlow DH, Lederman HM, Amorim L, Scanavini MA, Vigorito J , Comparison of relative mandibular growth vectors with high-resolution 3-dimensional imaging. Am J Orthod Dentofacial Orthop 2005 Jul;128(1):27-34

Cevidanes LH, Franco AA, Gerig G, Proffit WR, Slice DE, Enlow DH, Yamashita HK, Kim YJ, Scanavini MA, Vigorito J , Assessment of mandibular growth and response to orthopedic treatment with 3-dimensional magnetic resonance images. Am J Orthod Dentofacial Orthop 2005 Jul;128(1):16-26

Styner M, Lieberman JA, McClure RK, Weinberger DR, Jones DW, Gerig , Morphometric analysis of lateral ventricles in schizophrenia and healthy controls regarding genetic and disease-specific factors. Proc Natl Acad Sci U S A 2005 Mar 29;102(13):4872-7

Chakos MH, Schobel SA, Gu H, Gerig G, Bradford D, Charles C, Lieberman J , Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia. Br J Psychiatry 2005 Jan;186:26-31

Prastawa M, Bullitt E, Gerig , Synthetic ground truth for validation of brain tumor MRI segmentation. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 2005;8(Pt 1):26-33

Mortamet B, Zeng D, Gerig G, Prastawa M, Bullitt , Effects of healthy aging measured by intracranial compartment volumes using a designed MR brain database. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 2005;8(Pt 1):383-91

Corouge I, Fletcher PT, Joshi S, Gilmore JH, Gerig , Fiber tract-oriented statistics for quantitative diffusion tensor MRI analysis. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 2005;8(Pt 1):131-9

Terriberry TB, Joshi SC, Gerig , Hypothesis testing with nonlinear shape models. Inf Process Med Imaging 2005;19:15-26

Bullitt E, Ewend MG, Aylward S, Lin W, Gerig G, Joshi S, Jung I, Muller K, Smith J , Abnormal vessel tortuosity as a marker of treatment response of malignant gliomas: preliminary report. Technol Cancer Res Treat 2004 Dec;3(6):577-84

Gilmore JH, Zhai G, Wilber K, Smith JK, Lin W, Gerig , 3 Tesla magnetic resonance imaging of the brain in newborns. Psychiatry Res 2004 Nov 15;132(1):81-5

Prastawa M, Bullitt E, Ho S, Gerig , A brain tumor segmentation framework based on outlier detection. Med Image Anal 2004 Sep;8(3):275-83

Styner M, Lieberman JA, Pantazis D, Gerig , Boundary and medial shape analysis of the hippocampus in schizophrenia. Med Image Anal 2004 Sep;8(3):197-203

Joshi S, Davis B, Jomier M, Gerig , Unbiased diffeomorphic atlas construction for computational anatomy. Neuroimage 2004;23 Suppl 1:S151-60

Gerig G, Gouttard S, Corouge , Analysis of brain white matter via fiber tract modeling. Conf Proc IEEE Eng Med Biol Soc 2004;6:4421-4

Prastawa M, Bullitt E, Moon N, Van Leemput K, Gerig , Automatic brain tumor segmentation by subject specific modification of atlas priors. Acad Radiol 2003 Dec;10(12):1341-8

Zhai G, Lin W, Wilber KP, Gerig G, Gilmore J , Comparisons of regional white matter diffusion in healthy neonates and adults performed with a 3.0-T head-only MR imaging unit. Radiology 2003 Dec;229(3):673-81

Lin W, An H, Chen Y, Nicholas P, Zhai G, Gerig G, Gilmore J, Bullitt , Practical consideration for 3T imaging. Magn Reson Imaging Clin N Am 2003 Nov;11(4):615-39, vi

Bullitt E, Gerig G, Pizer SM, Lin W, Aylward S , Measuring tortuosity of the intracerebral vasculature from MRA images. IEEE Trans Med Imaging 2003 Sep;22(9):1163-71

Styner M, Gerig G, Lieberman J, Jones D, Weinberger , Statistical shape analysis of neuroanatomical structures based on medial models. Med Image Anal 2003 Sep;7(3):207-20

Joshi S, Lorenzen P, Gerig G, Bullitt , Structural and radiometric asymmetry in brain images. Med Image Anal 2003 Jun;7(2):155-70

Shenton ME, Gerig G, McCarley RW, Szekely G, Kikinis , Amygdala-hippocampal shape differences in schizophrenia: the application of 3D shape models to volumetric MR data. Psychiatry Res 2002 Aug 20;115(1-2):15-35

Gilmore JH, Gerig G, Specter B, Charles HC, Wilber JS, Hertzberg BS, Kliewer M , Infant cerebral ventricle volume: a comparison of 3-D ultrasound and magnetic resonance imaging. Ultrasound Med Biol 2001 Aug;27(8):1143-6