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Dan J. Kadrmas
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Phone: 801-581-5937
Office: UCAIR, 729 Arapeen Drive

Dan J. Kadrmas

Associate Professor of Radiology
Adjunct Professor, Bioengineering



Research

Positron Emission Tomography


Current Research

Functional imaging with positron emission tomography (PET), especially advanced technologies for:
- Multi-tracer PET tumor imaging to characterize multiple aspects of tumor physiology, e.g. glucose metabolism + blood flow + hypoxia + growth
- Multi-modality PET/CT and PET/MRI imaging, where high resolution anatomic imaging is coupled with functional PET to improve the resolution, quantitation, and descriptive value of the functional imaging information
- Statistical fully-3D tomographic image reconstruction algoriths with advanced physics and statistical modeling


Selected Publications

Morey AM, Noo F, Kadrmas DJ, Effect of Using 2mm Voxels on Observer Performance for PET Lesion Detection. IEEE Trans Nucl Sci 2016 Jun;63(3):1359-1366

Zhang JL, Michael Morey A, Kadrmas DJ, Application of separable parameter space techniques to multi-tracer PET compartment modeling. Phys Med Biol 2016 Feb 7;61(3):1238-58

Horn KP, Yap JT, Agarwal N, Morton KA, Kadrmas DJ, Beardmore B, Butterfield RI, Boucher K, Hoffman JM, FDG and FLT-PET for Early measurement of response to 37.5 mg daily sunitinib therapy in metastatic renal cell carcinoma. Cancer Imaging 2015 Sep 3;15:15

Morey AM, Kadrmas DJ, Effect of varying number of OSEM subsets on PET lesion detectability. J Nucl Med Technol 2013 Dec;41(4):268-73

Kadrmas DJ, Hoffman JM, Methodology for quantitative rapid multi-tracer PET tumor characterizations. Theranostics 2013 Oct 4;3(10):757-73

Kadrmas DJ, Oktay MB, Generalized separable parameter space techniques for fitting 1K-5K serial compartment models. Med Phys 2013 Jul;40(7):072502

Kadrmas DJ, Rust TC, Hoffman JM, Single-scan dual-tracer FLT+FDG PET tumor characterization. Phys Med Biol 2013 Feb 7;58(3):429-49

Kadrmas DJ, Oktay MB, Casey ME, Hamill JJ, Effect of Scan Time on Oncologic Lesion Detection in Whole-Body PET. IEEE Trans Nucl Sci 2012 Oct;59(5):1940-1947

Zeng GL, Kadrmas DJ, Gullberg GT, Fourier domain closed-form formulas for estimation of kinetic parameters in reversible multi-compartment models. Biomed Eng Online 2012 Sep 20;11:70

Zeng GL, Hernandez A, Kadrmas DJ, Gullberg GT, Kinetic parameter estimation using a closed-form expression via integration by parts. Phys Med Biol 2012 Sep 21;57(18):5809-21

Enslow MS, Zollinger LV, Morton KA, Butterfield RI, Kadrmas DJ, Christian PE, Boucher KM, Heilbrun ME, Jensen RL, Hoffman JM, Comparison of 18F-fluorodeoxyglucose and 18F-fluorothymidine PET in differentiating radiation necrosis from recurrent glioma. Clin Nucl Med 2012 Sep;37(9):854-61

Zeng GL, Gullberg GT, Kadrmas DJ, Closed-form kinetic parameter estimation solution to the truncated data problem. Phys Med Biol 2010 Dec 21;55(24):7453-68

Black NF, McJames S, Kadrmas DJ, Rapid Multi-Tracer PET Tumor Imaging With F-FDG and Secondary Shorter-Lived Tracers. IEEE Trans Nucl Sci 2009 Oct 1;56(5):2750-2758

Kadrmas DJ, Casey ME, Conti M, Jakoby BW, Lois C, Townsend DW, Impact of time-of-flight on PET tumor detection. J Nucl Med 2009 Aug;50(8):1315-23

Kadrmas DJ, Casey ME, Black NF, Hamill JJ, Panin VY, Conti M, Experimental comparison of lesion detectability for four fully-3D PET reconstruction schemes. IEEE Trans Med Imaging 2009 Apr;28(4):523-34

Pack NA, DiBella EV, Rust TC, Kadrmas DJ, McGann CJ, Butterfield R, Christian PE, Hoffman JM, Estimating myocardial perfusion from dynamic contrast-enhanced CMR with a model-independent deconvolution method. J Cardiovasc Magn Reson 2008 Nov 12;10:52

Kadrmas DJ, Rotate-and-slant projector for fast LOR-based fully-3-D iterative PET reconstruction. IEEE Trans Med Imaging 2008 Aug;27(8):1071-83

Black NF, McJames S, Rust TC, Kadrmas DJ, Evaluation of rapid dual-tracer (62)Cu-PTSM + (62)Cu-ATSM PET in dogs with spontaneously occurring tumors. Phys Med Biol 2008 Jan 7;53(1):217-32

Rust TC, DiBella EV, McGann CJ, Christian PE, Hoffman JM, Kadrmas DJ, Rapid dual-injection single-scan 13N-ammonia PET for quantification of rest and stress myocardial blood flows. Phys Med Biol 2006 Oct 21;51(20):5347-62

Rust TC, Kadrmas DJ, Rapid dual-tracer PTSM+ATSM PET imaging of tumour blood flow and hypoxia: a simulation study. Phys Med Biol 2006 Jan 7;51(1):61-75

Kadrmas DJ, LOR-OSEM: statistical PET reconstruction from raw line-of-response histograms. Phys Med Biol 2004 Oct 21;49(20):4731-44

Rust TC, Kadrmas DJ, Survey of parallel slat collimator designs for hybrid PET imaging. Phys Med Biol 2003 Mar 21;48(6):N97-104

Kadrmas DJ, Christian PE, Comparative evaluation of lesion detectability for 6 PET imaging platforms using a highly reproducible whole-body phantom with (22)Na lesions and localization ROC analysis. J Nucl Med 2002 Nov;43(11):1545-54

Khare HS, Dibella EV, Kadrmas DJ, Christian PE, Gullberg GT, Comparison of Static and Dynamic Cardiac Perfusion Thallium-201 SPECT. IEEE Trans Nucl Sci 2001 Jun;48(3):774

Di Bella EV, Kadrmas DJ, Christian PE, Feasibility of dual-isotope coincidence/single-photon imaging of the myocardium. J Nucl Med 2001 Jun;42(6):944-50

Kadrmas DJ, Gullberg GT, 4D maximum a posteriori reconstruction in dynamic SPECT using a compartmental model-based prior. Phys Med Biol 2001 May;46(5):1553-74

Di Bella EV, Ross SG, Kadrmas DJ, Khare HS, Christian PE, McJames S, Gullberg AG, Compartmental modeling of technetium-99m-labeled teboroxime with dynamic single-photon emission computed tomography: comparison with static thallium-201 in a canine model. Invest Radiol 2001 Mar;36(3):178-85

Di Bella EV, Khare HS, Kadrmas DJ, Gullberg GT, SPECT Imaging of Teboroxime during Myocardial Blood Flow Changes. IEEE Trans Nucl Sci 2000 Jun;47(3):nihpa165910

Kadrmas DJ, DiBella EV, Huesman RH, Gullberg GT, Analytical propagation of errors in dynamic SPECT: estimators, degrading factors, bias and noise. Phys Med Biol 1999 Aug;44(8):1997-2014

Kadrmas DJ, Frey EC, Tsui BM, Simultaneous technetium-99m/thallium-201 SPECT imaging with model-based compensation for cross-contaminating effects. Phys Med Biol 1999 Jul;44(7):1843-60

Kadrmas DJ, Frey EC, Tsui BM, Application of reconstruction-based scatter compensation to thallium-201 SPECT: implementations for reduced reconstructed image noise. IEEE Trans Med Imaging 1998 Jun;17(3):325-33

Kadrmas DJ, Frey EC, Karimi SS, Tsui BM, Fast implementations of reconstruction-based scatter compensation in fully 3D SPECT image reconstruction. Phys Med Biol 1998 Apr;43(4):857-73