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James P. Keener

Phone: 801-581-6089
Office: 233 JWB

James P. Keener

Distinguished Professor of Mathematics
Adjunct Professor, Bioengineering

Selected Publications

Lewis OL, Keener JP, Fogelson AL, A physics-based model for maintenance of the pH gradient in the gastric mucus layer. Am J Physiol Gastrointest Liver Physiol 2017 Sep 7;:ajpgi.00221.2017

Bannish BE, Chernysh IN, Keener JP, Fogelson AL, Weisel JW, Molecular and Physical Mechanisms of Fibrinolysis and Thrombolysis from Mathematical Modeling and Experiments. Sci Rep 2017 Aug 7;7(1):6914

Miles CE, Keener JP, Bidirectionality from cargo thermal fluctuations in motor-mediated transport. J Theor Biol 2017 Jul 7;424:37-48

Lawley SD, Keener JP, Rebinding in biochemical reactions on membranes. Phys Biol 2017 Jul 28;14(5):056002

Renault TT, Abraham AO, Bergmiller T, Paradis G, Rainville S, Charpentier E, Guet CC, Tu Y, Namba K, Keener JP, Minamino T, Erhardt M, Bacterial flagella grow through an injection-diffusion mechanism. Elife 2017 Mar 6;6:

Lawley SD, Keener JP, Including Rebinding Reactions in Well-Mixed Models of Distributive Biochemical Reactions. Biophys J 2016 Nov 15;111(10):2317-2326

Veeraraghavan R, Lin J, Keener JP, Gourdie R, Poelzing S, Potassium channels in the Cx43 gap junction perinexus modulate ephaptic coupling: an experimental and modeling study. Pflugers Arch 2016 Oct;468(10):1651-61

George SA, Sciuto KJ, Lin J, Salama ME, Keener JP, Gourdie RG, Poelzing S, Extracellular sodium and potassium levels modulate cardiac conduction in mice heterozygous null for the Connexin43 gene. Pflugers Arch 2015 Nov;467(11):2287-97

Veeraraghavan R, Lin J, Hoeker GS, Keener JP, Gourdie RG, Poelzing S, Sodium channels in the Cx43 gap junction perinexus may constitute a cardiac ephapse: an experimental and modeling study. Pflugers Arch 2015 Oct;467(10):2093-105

Shtylla B, Keener JP, Mathematical modeling of bacterial track-altering motors: Track cleaving through burnt-bridge ratchets. Phys Rev E Stat Nonlin Soft Matter Phys 2015 Apr;91(4):042711

Keener JP, Shtylla B, A mathematical model of force generation by flexible kinetochore-microtubule attachments. Biophys J 2014 Mar 4;106(5):998-1007

Mageswaran SK, Dixon MG, Curtiss M, Keener JP, Babst M, Binding to any ESCRT can mediate ubiquitin-independent cargo sorting. Traffic 2014 Feb;15(2):212-29

Lin J, Keener JP, Microdomain effects on transverse cardiac propagation. Biophys J 2014 Feb 18;106(4):925-31

Hunter GA, Keener JP, Mechanisms underlying the additive and redundant Qrr phenotypes in Vibrio harveyi and Vibrio cholerae. J Theor Biol 2014 Jan 7;340:38-49

Hunter GA, Vasquez FG, Keener JP, A mathematical model and quantitative comparison of the small RNA circuit in the Vibrio harveyi and Vibrio cholerae quorum sensing systems. Phys Biol 2013 Aug;10(4):046007

Lin J, Keener JP, Ephaptic coupling in cardiac myocytes. IEEE Trans Biomed Eng 2013 Feb;60(2):576-82

Sircar S, Keener JP, Fogelson AL, The effect of divalent vs. monovalent ions on the swelling of mucin-like polyelectrolyte gels: governing equations and equilibrium analysis. J Chem Phys 2013 Jan 7;138(1):014901

Du J, Keener JP, Guy RD, Fogelson AL, Low-Reynolds-number swimming in viscous two-phase fluids. Phys Rev E Stat Nonlin Soft Matter Phys 2012 Mar;85(3-2):036304

Du J, Keener JP, Guy RD, Fogelson AL, Low-Reynolds-number swimming in viscous two-phase fluids. Phys Rev E Stat Nonlin Soft Matter Phys 2012 Mar;85(3 Pt 2):036304

Keener JP, Newby JM, Perturbation analysis of spontaneous action potential initiation by stochastic ion channels. Phys Rev E Stat Nonlin Soft Matter Phys 2011 Jul;84(1 Pt 1):011918

Keener JP, Sircar S, Fogelson AL, Influence of the standard free energy on swelling kinetics of gels. Phys Rev E Stat Nonlin Soft Matter Phys 2011 Apr;83(4 Pt 1):041802

Erhardt M, Singer HM, Wee DH, Keener JP, Hughes KT, An infrequent molecular ruler controls flagellar hook length in Salmonella enterica. EMBO J 2011 Jun 7;30(14):2948-61

Lin J, Keener JP, Modeling electrical activity of myocardial cells incorporating the effects of ephaptic coupling. Proc Natl Acad Sci U S A 2010 Dec 7;107(49):20935-40

Tania N, Keener JP, Calsequestrin mediates changes in spontaneous calcium release profiles. J Theor Biol 2010 Aug 7;265(3):359-76

Tania N, Keener JP, Calsequestrin mediates changes in spontaneous calcium release profiles. J Theor Biol 2010 Jun 1;:

Fogelson AL, Keener JP, Toward an understanding of fibrin branching structure. Phys Rev E Stat Nonlin Soft Matter Phys 2010 May;81(5 Pt 1):051922

Shtylla B, Keener JP, A mechanomolecular model for the movement of chromosomes during mitosis driven by a minimal kinetochore bicyclic cascade. J Theor Biol 2010 Apr 21;263(4):455-70

Keener JP, Exact reductions of Markovian dynamics for ion channels with a single permissive state. J Math Biol 2010 Apr;60(4):473-9

Keener JP, A molecular ruler mechanism for length control of extended protein structures in bacteria. J Theor Biol 2010 Apr 21;263(4):481-9

Keener JP, Invariant manifold reductions for Markovian ion channel dynamics. J Math Biol 2009 Mar;58(3):447-57

Copene ED, Keener JP, Ephaptic coupling of cardiac cells through the junctional electric potential. J Math Biol 2008 Aug;57(2):265-84

Lee YS, Keener JP, A calcium-induced calcium release mechanism mediated by calsequestrin. J Theor Biol 2008 May 2;:

Guy RD, Fogelson AL, Keener JP, Fibrin gel formation in a shear flow. Math Med Biol 2007 Mar;24(1):111-30

Keener JP, How Salmonella Typhimurium measures the length of flagellar filaments. Bull Math Biol 2006 Oct;68(7):1761-78

Keener JP, Stochastic calcium oscillations. Math Med Biol 2006 Mar;23(1):1-25

Keener JP, A model for length control of flagellar hooks of Salmonella typhimurium. J Theor Biol 2005 May 21;234(2):263-75

Keener JP, The topology of defibrillation. J Theor Biol 2004 Oct 21;230(4):459-73

Keener JP, Model for the onset of fibrillation following coronary artery occlusion. J Cardiovasc Electrophysiol 2003 Nov;14(11):1225-32

Keener JP, Cytrynbaum E, The effect of spatial scale of resistive inhomogeneity on defibrillation of cardiac tissue. J Theor Biol 2003 Jul 21;223(2):233-48

Yi CS, Fogelson AL, Keener JP, Peskin CS, A mathematical study of volume shifts and ionic concentration changes during ischemia and hypoxia. J Theor Biol 2003 Jan 7;220(1):83-106

Spitzer KW, Skolnick RL, Peercy BE, Keener JP, Vaughan-Jones RD, Facilitation of intracellular H(+) ion mobility by CO(2)/HCO(3)(-) in rabbit ventricular myocytes is regulated by carbonic anhydrase. J Physiol 2002 May 15;541(Pt 1):159-67

Keener JP, Diffusion induced oscillatory insulin secretion. Bull Math Biol 2001 Jul;63(4):625-41

Keener JP, Lewis TJ, The biphasic mystery: why a biphasic shock is more effective than a monophasic shock for defibrillation. J Theor Biol 1999 Sep 7;200(1):1-17

Keener JP, Bogar K, A numerical method for the solution of the bidomain equations in cardiac tissue. Chaos 1998 Mar;8(1):234-241

Keener JP, The effect of gap junctional distribution on defibrillation. Chaos 1998 Mar;8(1):175-187

Keener JP, Panfilov AV, A biophysical model for defibrillation of cardiac tissue. Biophys J 1996 Sep;71(3):1335-45

Keener JP, Direct activation and defibrillation of cardiac tissue. J Theor Biol 1996 Feb 7;178(3):313-24

Panfilov AV, Keener JP, Generation of reentry in anisotropic myocardium. J Cardiovasc Electrophysiol 1993 Aug;4(4):412-21

Keener JP, An eikonal-curvature equation for action potential propagation in myocardium. J Math Biol 1991;29(7):629-51

Keener JP, The effects of discrete gap junction coupling on propagation in myocardium. J Theor Biol 1991 Jan 7;148(1):49-82

Keener JP, The effects of gap junctions on propagation in myocardium: a modified cable theory. Ann N Y Acad Sci 1990;591:257-77

Keener JP, On the formation of circulating patterns of excitation in anisotropic excitable media. J Math Biol 1988;26(1):41-56