Personal Profile
Home → Directory → Faculty → Jindrich Kopecek
Jindrich  Kopecek
E-mail:

Phone: 801-581-7211
Office: 205B BPRB

Jindrich Kopecek

Ph.D., D.Sc. Czechoslovak Academy of Sciences



Research

Research in the Biomedical Polymers Laboratory focuses on the design, synthesis, and characterization of biorecognizable biomedical polymers.


Selected Publications

Pelaz B, Alexiou C, Alvarez-Puebla RA, Alves F, Andrews AM, Ashraf S, Balogh LP, Ballerini L, Bestetti A, Brendel C, Bosi S, Carril M, Chan WC, Chen C, Chen X, Chen X, Cheng Z, Cui D, Du J, Dullin C, Escudero A, Feliu N, Gao M, George M, Gogotsi Y, Grünwe, Diverse Applications of Nanomedicine. ACS Nano 2017 Mar 28;11(3):2313-2381

Yang J, Zhang R, Pan H, Li Y, Fang Y, Zhang L, Kopecek J, Backbone Degradable N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates with Gemcitabine and Paclitaxel: Impact of Molecular Weight on Activity toward Human Ovarian Carcinoma Xenografts. Mol Pharm 2017 Feb 3;:

Zhang L, Fang Y, Kopecek J, Yang J, A new construct of antibody-drug conjugates for treatment of B-cell non-Hodgkin's lymphomas. Eur J Pharm Sci 2017 Feb 27;:

Low SA, Galliford CV, Jones-Hall YL, Roy J, Yang J, Low PS, Kopecek J, Healing efficacy of fracture-targeted GSK3ß inhibitor-loaded micelles for improved fracture repair. Nanomedicine (Lond) 2017 Feb;12(3):185-193

Zhang R, Yang J, Radford DC, Fang Y, Kopecek J, FRET Imaging of Enzyme-Responsive HPMA Copolymer Conjugate. Macromol Biosci 2017 Jan;17(1):

Zhang L, Fang Y, Yang J, Kopecek J, Drug-free macromolecular therapeutics: Impact of structure on induction of apoptosis in Raji B cells. J Control Release 2016 Dec 24;:

Yang J, Kopecek J, Design of smart HPMA copolymer-based nanomedicines. J Control Release 2016 Oct 28;240:9-23

Zhang L, Zhang R, Yang J, Wang J, Kopecek J, Indium-based and iodine-based labeling of HPMA copolymer-epirubicin conjugates: Impact of structure on the in vivo fate. J Control Release 2016 Aug 10;235:306-18

Hartley JM, Zhang R, Gudheti M, Yang J, Kopecek J, Tracking and quantifying polymer therapeutic distribution on a cellular level using 3D dSTORM. J Control Release 2016 Jun 10;231:50-9

Zhang R, Yang J, Zhou Y, Shami PJ, Kopecek J, N-(2-Hydroxypropyl)methacrylamide Copolymer-Drug Conjugates for Combination Chemotherapy of Acute Myeloid Leukemia. Macromol Biosci 2016 Jan;16(1):121-8

Chu TW, Feng J, Yang J, Kopecek J, Hybrid polymeric hydrogels via peptide nucleic acid (PNA)/DNA complexation. J Control Release 2015 Dec 28;220(Pt B):608-16

Yang J, Kopecek J, POLYMERIC BIOMATERIALS AND NANOMEDICINES. J Drug Deliv Sci Technol 2015 Dec 1;30(Pt B):318-330

Yang J, Zhang R, Radford DC, Kopecek J, FRET-trackable biodegradable HPMA copolymer-epirubicin conjugates for ovarian carcinoma therapy. J Control Release 2015 Nov 28;218:36-44

Yang J, Zhang R, Christopher Radford D, Kopecek J, Design and synthesis of FRET-trackable HPMA-based biodegradable conjugates for drug/gene delivery. J Control Release 2015 Sep 10;213:e58

Hartley JM, Chu TW, Peterson EM, Zhang R, Yang J, Harris J, Kopecek J, Super-Resolution Imaging and Quantitative Analysis of Membrane Protein/Lipid Raft Clustering Mediated by Cell-Surface Self-Assembly of Hybrid Nanoconjugates. Chembiochem 2015 Aug 17;16(12):1725-9

Chu TW, Kopecek J, Drug-Free Macromolecular Therapeutics--A New Paradigm in Polymeric Nanomedicines. Biomater Sci 2015 Jul;3(7):908-22

Zhang R, Yang J, Chu TW, Hartley JM, Kopecek J, Multimodality imaging of coiled-coil mediated self-assembly in a "drug-free" therapeutic system. Adv Healthc Mater 2015 May;4(7):1054-65

Chu TW, Zhang R, Yang J, Chao MP, Shami PJ, Kopecek J, A Two-Step Pretargeted Nanotherapy for CD20 Crosslinking May Achieve Superior Anti-Lymphoma Efficacy to Rituximab. Theranostics 2015;5(8):834-46

Zhou Y, Yang J, Zhang R, Kopecek J, Combination therapy of prostate cancer with HPMA copolymer conjugates containing PI3K/mTOR inhibitor and docetaxel. Eur J Pharm Biopharm 2015 Jan;89:107-15

Peng ZH, Kopecek J, HPMA Copolymer CXCR4 Antagonist Conjugates Substantially Inhibited the Migration of Prostate Cancer Cells. ACS Macro Lett 2014 Dec 16;3(12):1240-1243

Chu TW, Kosak KM, Shami PJ, Kopecek J, Drug-free macromolecular therapeutics induce apoptosis of patient chronic lymphocytic leukemia cells. Drug Deliv Transl Res 2014 Dec;4(5-6):389-94

Low SA, Yang J, Kopecek J, Bone-targeted acid-sensitive doxorubicin conjugate micelles as potential osteosarcoma therapeutics. Bioconjug Chem 2014 Nov 19;25(11):2012-20

Yang J, Kopecek J, Macromolecular therapeutics. J Control Release 2014 Sep 28;190:288-303

Zhang R, Yang J, Sima M, Zhou Y, Kopecek J, Sequential combination therapy of ovarian cancer with degradable N-(2-hydroxypropyl)methacrylamide copolymer paclitaxel and gemcitabine conjugates. Proc Natl Acad Sci U S A 2014 Aug 19;111(33):12181-6

Kverka M, Hartley JM, Chu TW, Yang J, Heidchen R, Kopecek J, Immunogenicity of coiled-coil based drug-free macromolecular therapeutics. Biomaterials 2014 Jul;35(22):5886-96

Duangjai A, Luo K, Zhou Y, Yang J, Kopecek J, Combination cytotoxicity of backbone degradable HPMA copolymer gemcitabine and platinum conjugates toward human ovarian carcinoma cells. Eur J Pharm Biopharm 2014 May;87(1):187-96

Peng ZH, Kopecek J, Synthesis and activity of tumor-homing peptide iRGD and histone deacetylase inhibitor valproic acid conjugate. Bioorg Med Chem Lett 2014 Apr 15;24(8):1928-33

Kopecek J, Stanwix H, Interview with Professor Jindrich Kopecek. Nanomedicine (Lond) 2014 Apr;9(5):577-9

Chu TW, Yang J, Zhang R, Sima M, Kopecek J, Cell surface self-assembly of hybrid nanoconjugates via oligonucleotide hybridization induces apoptosis. ACS Nano 2014 Jan 28;8(1):719-30

Zhou Y, Yang J, Rhim JS, Kopecek J, HPMA copolymer-based combination therapy toxic to both prostate cancer stem/progenitor cells and differentiated cells induces durable anti-tumor effects. J Control Release 2013 Dec 28;172(3):946-53

Larson N, Yang J, Ray A, Cheney DL, Ghandehari H, Kopecek J, Biodegradable multiblock poly(N-2-hydroxypropyl)methacrylamide gemcitabine and paclitaxel conjugates for ovarian cancer cell combination treatment. Int J Pharm 2013 Sep 15;454(1):435-43

Pan H, Sima M, Miller SC, Kopecková P, Yang J, Kopecek J, Efficiency of high molecular weight backbone degradable HPMA copolymer-prostaglandin E1 conjugate in promotion of bone formation in ovariectomized rats. Biomaterials 2013 Sep;34(27):6528-38

Pan H, Sima M, Yang J, Kopecek J, Synthesis of long-circulating, backbone degradable HPMA copolymer-doxorubicin conjugates and evaluation of molecular-weight-dependent antitumor efficacy. Macromol Biosci 2013 Feb;13(2):155-60

Zhang R, Luo K, Yang J, Sima M, Sun Y, Janát-Amsbury MM, Kopecek J, Synthesis and evaluation of a backbone biodegradable multiblock HPMA copolymer nanocarrier for the systemic delivery of paclitaxel. J Control Release 2013 Feb 28;166(1):66-74

Kopecek J, Polymer-drug conjugates: origins, progress to date and future directions. Adv Drug Deliv Rev 2013 Jan;65(1):49-59

Zhou Y, Kopecek J, Biological rationale for the design of polymeric anti-cancer nanomedicines. J Drug Target 2013 Jan;21(1):1-26

Chu TW, Yang J, Kopecek J, Anti-CD20 multivalent HPMA copolymer-Fab' conjugates for the direct induction of apoptosis. Biomaterials 2012 Oct;33(29):7174-81

Low SA, Kopecek J, Targeting polymer therapeutics to bone. Adv Drug Deliv Rev 2012 Sep;64(12):1189-204

Kopecek J, Yang J, Smart self-assembled hybrid hydrogel biomaterials. Angew Chem Int Ed Engl 2012 Jul 23;51(30):7396-417

Fowers KD, Kopecek J, Targeting of multidrug-resistant human ovarian carcinoma cells with anti-P-glycoprotein antibody conjugates. Macromol Biosci 2012 Apr;12(4):502-14

Liu J, Kopecková P, Pan H, Sima M, Bühler P, Wolf P, Elsässer-Beile U, Kopecek J, Prostate-cancer-targeted N-(2-hydroxypropyl)methacrylamide copolymer/docetaxel conjugates. Macromol Biosci 2012 Mar;12(3):412-22

Johnson RN, Kopecková P, Kopecek J, Biological activity of anti-CD20 multivalent HPMA copolymer-Fab' conjugates. Biomacromolecules 2012 Mar 12;13(3):727-35

Zhou Y, Yang J, Kopecek J, Selective inhibitory effect of HPMA copolymer-cyclopamine conjugate on prostate cancer stem cells. Biomaterials 2012 Feb;33(6):1863-72

Wu K, Yang J, Liu J, Kopecek J, Coiled-coil based drug-free macromolecular therapeutics: in vivo efficacy. J Control Release 2012 Jan 10;157(1):126-31

Krimmer SG, Pan H, Liu J, Yang J, Kopecek J, Synthesis and characterization of poly(e-caprolactone)-block-poly[N-(2-hydroxypropyl)methacrylamide] micelles for drug delivery. Macromol Biosci 2011 Aug 11;11(8):1041-51

Wu LC, Yang J, Kopecek J, Hybrid hydrogels self-assembled from graft copolymers containing complementary ß-sheets as hydroxyapatite nucleation scaffolds. Biomaterials 2011 Aug;32(23):5341-53

Luo K, Yang J, Kopecková P, Kopecek J, Biodegradable Multiblock Poly[N-(2-hydroxypropyl)methacrylamide] via Reversible Addition-Fragmentation Chain Transfer Polymerization and Click Chemistry. Macromolecules 2011 Apr 26;44(8):2481-2488

Yang J, Luo K, Pan H, Kopecková P, Kopecek J, Synthesis of Biodegradable Multiblock Copolymers by Click Coupling of RAFT-Generated HeterotelechelicPolyHPMA Conjugates. React Funct Polym 2011 Mar 1;71(3):294-302

Pan H, Yang J, Kopecková P, Kopecek J, Backbone degradable multiblock N-(2-hydroxypropyl)methacrylamide copolymer conjugates via reversible addition-fragmentation chain transfer polymerization and thiol-ene coupling reaction. Biomacromolecules 2011 Jan 10;12(1):247-52

Giantsos-Adams K, Lopez-Quintero V, Kopeckova P, Kopecek J, Tarbell JM, Dull R, Study of the therapeutic benefit of cationic copolymer administration to vascular endothelium under mechanical stress. Biomaterials 2011 Jan;32(1):288-94

Kopecek J, Biomaterials and drug delivery: past, present, and future. Mol Pharm 2010 Aug 2;7(4):922-5

Yang J, Jacobsen MT, Pan H, Kopecek J, Synthesis and characterization of enzymatically degradable PEG-based peptide-containing hydrogels. Macromol Biosci 2010 Apr 8;10(4):445-54

Liu J, Bauer H, Callahan J, Kopecková P, Pan H, Kopecek J, Endocytic uptake of a large array of HPMA copolymers: Elucidation into the dependence on the physicochemical characteristics. J Control Release 2010 Apr 2;143(1):71-9

Wu K, Liu J, Johnson RN, Yang J, Kopecek J, Drug-free macromolecular therapeutics: induction of apoptosis by coiled-coil-mediated cross-linking of antigens on the cell surface. Angew Chem Int Ed Engl 2010 Feb 15;49(8):1451-5

Kopecek J, Kopecková P, HPMA copolymers: origins, early developments, present, and future. Adv Drug Deliv Rev 2010 Feb 17;62(2):122-49

Kopecek J, HYDROGELS FROM SOFT CONTACT LENSES AND IMPLANTS TO SELF-ASSEMBLED NANOMATERIALS. J Polym Sci A Polym Chem 2009 Nov 15;47(22):5929-5946

Gao SQ, Sun Y, Kopecková P, Peterson CM, Kopecek J, Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts. Macromol Biosci 2009 Nov 10;9(11):1135-42

Radu-Wu LC, Yang J, Wu K, Kopecek J, Self-assembled hydrogels from poly[N-(2-hydroxypropyl)methacrylamide] grafted with beta-sheet peptides. Biomacromolecules 2009 Aug 10;10(8):2319-27

Sheparovych R, Roiter Y, Yang J, Kopec?ek J, Minko S, Stimuli-Responsive Properties of Peptide-Based Copolymers Studied via Directional Growth of Self-Assembled Patterns on Solid Substrate. Biomacromolecules 2009 Jul 13;10(7):1955-1961

Callahan J, Kopeckov P, Kopecek J, Intracellular trafficking and subcellular distribution of a large array of HPMA copolymers. Biomacromolecules 2009 Jul 13;10(7):1704-14

Liu J, Kopecková P, Bühler P, Wolf P, Pan H, Bauer H, Elsässer-Beile U, Kopecek J, Biorecognition and subcellular trafficking of HPMA copolymer-anti-PSMA antibody conjugates by prostate cancer cells. Mol Pharm 2009 May-Jun;6(3):959-70

Kopecek J, Yang J, Peptide-directed self-assembly of hydrogels. Acta Biomater 2009 Mar;5(3):805-16

Radu LC, Yang J, Kopecek J, Self-assembling diblock copolymers of poly[N-(2-hydroxypropyl)methacrylamide] and a beta-sheet peptide. Macromol Biosci 2009 Jan 9;9(1):36-44

Johnson RN, Kopecková P, Kopecek J, Synthesis and evaluation of multivalent branched HPMA copolymer-Fab' conjugates targeted to the B-cell antigen CD20. Bioconjug Chem 2009 Jan;20(1):129-37

Miller SC, Pan H, Wang D, Bowman BM, Kopecková P, Kopecek J, Feasibility of using a bone-targeted, macromolecular delivery system coupled with prostaglandin E(1) to promote bone formation in aged, estrogen-deficient rats. Pharm Res 2008 Dec;25(12):2889-95

Yuan W, Yang J, Kopecková P, Kopecek J, Smart hydrogels containing adenylate kinase: translating substrate recognition into macroscopic motion. J Am Chem Soc 2008 Nov 26;130(47):15760-1

Cuchelkar V, Kopecková P, Kopecek J, Novel HPMA copolymer-bound constructs for combined tumor and mitochondrial targeting. Mol Pharm 2008 Sep-Oct;5(5):776-86

Hongrapipat J, Kopecková P, Liu J, Prakongpan S, Kopecek J, Combination chemotherapy and photodynamic therapy with fab' fragment targeted HPMA copolymer conjugates in human ovarian carcinoma cells. Mol Pharm 2008 Sep-Oct;5(5):696-709

Pan H, Sima M, Kopecková P, Wu K, Gao S, Liu J, Wang D, Miller SC, Kopecek J, Biodistribution and pharmacokinetic studies of bone-targeting N-(2-hydroxypropyl)methacrylamide copolymer-alendronate conjugates. Mol Pharm 2008 Jul-Aug;5(4):548-58

Pan H, Liu J, Dong Y, Sima M, Kopecková P, Brandi ML, Kopecek J, Release of prostaglandin E(1) from N-(2-hydroxypropyl)methacrylamide copolymer conjugates by bone cells. Macromol Biosci 2008 Jul 7;8(7):599-605

Cuchelkar V, Kopecková P, Kopecek J, Synthesis and biological evaluation of disulfide-linked HPMA copolymer-mesochlorin e6 conjugates. Macromol Biosci 2008 May 13;8(5):375-83

Xu C, Kopecek J, Genetically engineered block copolymers: influence of the length and structure of the coiled-coil blocks on hydrogel self-assembly. Pharm Res 2008 Mar;25(3):674-82

Hongrapipat J, Kopecková P, Prakongpan S, Kopecek J, Enhanced antitumor activity of combinations of free and HPMA copolymer-bound drugs. Int J Pharm 2008 Mar 3;351(1-2):259-70

Yang J, Wu K, Konák C, Kopecek J, Dynamic light scattering study of self-assembly of HPMA hybrid graft copolymers. Biomacromolecules 2008 Feb;9(2):510-7

Gao SQ, Sun Y, Kopecková P, Peterson CM, Kopecek J, Pharmacokinetic modeling of absorption behavior of 9-aminocamptothecin (9-AC) released from colon-specific HPMA copolymer-9-AC conjugate in rats. Pharm Res 2008 Jan;25(1):218-26

Kopecek J, Hydrogel biomaterials: a smart future? Biomaterials 2007 Dec;28(34):5185-92

Malugin A, Kopecková P, Kopecek J, Liberation of doxorubicin from HPMA copolymer conjugate is essential for the induction of cell cycle arrest and nuclear fragmentation in ovarian carcinoma cells. J Control Release 2007 Dec 4;124(1-2):6-10

Pan H, Kopecková P, Liu J, Wang D, Miller SC, Kopecek J, Stability in plasmas of various species of HPMA copolymer-PGE1 conjugates. Pharm Res 2007 Dec;24(12):2270-80

Wang D, Miller SC, Shlyakhtenko LS, Portillo AM, Liu XM, Papangkorn K, Kopeckova P, Lyubchenko Y, Higuchi WI, Kopecek , Osteotropic Peptide That Differentiates Functional Domains of the Skeleton. Bioconjug Chem 2007 Aug 17;:

Ding H, Kopecková P, Kopecek J, Self-association properties of HPMA copolymers containing an amphipathic heptapeptide. J Drug Target 2007 Aug-Sep;15(7-8):465-74

Gao SQ, Lu ZR, Kopecková P, Kopecek J, Biodistribution and pharmacokinetics of colon-specific HPMA copolymer--9-aminocamptothecin conjugate in mice. J Control Release 2007 Feb 12;117(2):179-85

Wang D, Sima M, Mosley RL, Davda JP, Tietze N, Miller SC, Gwilt PR, Kopecková P, Kopecek J, Pharmacokinetic and biodistribution studies of a bone-targeting drug delivery system based on N-(2-hydroxypropyl)methacrylamide copolymers. Mol Pharm 2006 Nov-Dec;3(6):717-25

Ding H, Prodinger WM, Kopecek J, Two-step fluorescence screening of CD21-binding peptides with one-bead one-compound library and investigation of binding properties of N-(2-hydroxypropyl)methacrylamide copolymer-peptide conjugates. Biomacromolecules 2006 Nov;7(11):3037-46

Callahan J, Kopecek J, Semitelechelic HPMA copolymers functionalized with triphenylphosphonium as drug carriers for membrane transduction and mitochondrial localization. Biomacromolecules 2006 Aug;7(8):2347-56

Pan H, Kopeckova P, Wang D, Yang J, Miller S, Kopecek , Water-soluble HPMA copolymer-prostaglandin E1 conjugates containing a cathepsin K sensitive spacer. J Drug Target 2006 Jul;14(6):425-35

Pan H, Kopecková P, Wang D, Yang J, Miller S, Kopecek J, Water-soluble HPMA copolymer--prostaglandin E1 conjugates containing a cathepsin K sensitive spacer. J Drug Target 2006 Jul;14(6):425-35

Malugin A, Kopecková P, Kopecek J, HPMA copolymer-bound doxorubicin induces apoptosis in ovarian carcinoma cells by the disruption of mitochondrial function. Mol Pharm 2006 May-Jun;3(3):351-61

Yang J, Xu C, Wang C, Kopecek J, Refolding hydrogels self-assembled from N-(2-hydroxypropyl)methacrylamide graft copolymers by antiparallel coiled-coil formation. Biomacromolecules 2006 Apr;7(4):1187-95

Ding H, Prodinger WM, Kopecek J, Identification of CD21-binding peptides with phage display and investigation of binding properties of HPMA copolymer-peptide conjugates. Bioconjug Chem 2006 Mar-Apr;17(2):514-23

Yang J, Xu C, Kopecková P, Kopecek J, Hybrid hydrogels self-assembled from HPMA copolymers containing peptide grafts. Macromol Biosci 2006 Mar 14;6(3):201-9

Chivukula P, Dusek K, Wang D, Dusková-Smrcková M, Kopecková P, Kopecek J, Synthesis and characterization of novel aromatic azo bond-containing pH-sensitive and hydrolytically cleavable IPN hydrogels. Biomaterials 2006 Mar;27(7):1140-51

Gao SQ, Lu ZR, Petri B, Kopecková P, Kopecek J, Colon-specific 9-aminocamptothecin-HPMA copolymer conjugates containing a 1,6-elimination spacer. J Control Release 2006 Jan 10;110(2):323-31

Malugin A, Kopecková P, Kopecek J, HPMA copolymer-bound doxorubicin induces apoptosis in human ovarian carcinoma cells by a Fas-independent pathway. Mol Pharm 2004 May-Jun;1(3):174-82

Wang D, Miller SC, Kopecková P, Kopecek J, Bone-targeting macromolecular therapeutics. Adv Drug Deliv Rev 2005 May 25;57(7):1049-76

Wang D, Miller SC, Kopecek J, Targeted drug delivery for musculoskeletal diseases. Adv Drug Deliv Rev 2005 May 25;57(7):935-7

Xu C, Breedveld V, Kopecek J, Reversible hydrogels from self-assembling genetically engineered protein block copolymers. Biomacromolecules 2005 May-Jun;6(3):1739-49

Nori A, Kopecek J, Intracellular targeting of polymer-bound drugs for cancer chemotherapy. Adv Drug Deliv Rev 2005 Feb 28;57(4):609-36

Miller SC, Wang D, Kopecková P, Kopecek J, Biopolymer-based delivery systems for advanced imaging and skeletal tissue-specific therapeutics. J Bone Miner Metab 2005;23 Suppl:103-8

Hyde RM, Jensen K, Kopecek J, Broom AD, Confocal microscopy studies of a model oligoribonucleotide HIV inhibitor. Nucleosides Nucleotides Nucleic Acids 2005;24(10-12):1875-84

Wang D, Miller SC, Sima M, Parker D, Buswell H, Goodrich KC, Kopecková P, Kopecek J, The arthrotropism of macromolecules in adjuvant-induced arthritis rat model: a preliminary study. Pharm Res 2004 Oct;21(10):1741-9

Wang D, Li W, Pechar M, Kopecková P, Brömme D, Kopecek J, Cathepsin K inhibitor-polymer conjugates: potential drugs for the treatment of osteoporosis and rheumatoid arthritis. Int J Pharm 2004 Jun 11;277(1-2):73-9

Nishiyama N, Nori A, Malugin A, Kasuya Y, Kopecková P, Kopecek J, Free and N-(2-hydroxypropyl)methacrylamide copolymer-bound geldanamycin derivative induce different stress responses in A2780 human ovarian carcinoma cells. Cancer Res 2003 Nov 15;63(22):7876-82

Merdan T, Callahan J, Petersen H, Kunath K, Bakowsky U, Kopecková P, Kissel T, Kopecek J, Pegylated polyethylenimine-Fab' antibody fragment conjugates for targeted gene delivery to human ovarian carcinoma cells. Bioconjug Chem 2003 Sep-Oct;14(5):989-96

Wang D, Miller S, Sima M, Kopecková P, Kopecek J, Synthesis and evaluation of water-soluble polymeric bone-targeted drug delivery systems. Bioconjug Chem 2003 Sep-Oct;14(5):853-9

Kopecek J, Smart and genetically engineered biomaterials and drug delivery systems. Eur J Pharm Sci 2003 Sep;20(1):1-16

Tijerina M, Kopecková P, Kopecek J, Mechanisms of cytotoxicity in human ovarian carcinoma cells exposed to free Mce6 or HPMA copolymer-Mce6 conjugates. Photochem Photobiol 2003 Jun;77(6):645-52

Tijerina M, Kopecková P, Kopecek J, Correlation of subcellular compartmentalization of HPMA copolymer-Mce6 conjugates with chemotherapeutic activity in human ovarian carcinoma cells. Pharm Res 2003 May;20(5):728-37

Jensen KD, Nori A, Tijerina M, Kopecková P, Kopecek J, Cytoplasmic delivery and nuclear targeting of synthetic macromolecules. J Control Release 2003 Feb 21;87(1-3):89-105

Peterson CM, Shiah JG, Sun Y, Kopecková P, Minko T, Straight RC, Kopecek J, HPMA copolymer delivery of chemotherapy and photodynamic therapy in ovarian cancer. Adv Exp Med Biol 2003;519:101-23

Nori A, Jensen KD, Tijerina M, Kopecková P, Kopecek J, Tat-conjugated synthetic macromolecules facilitate cytoplasmic drug delivery to human ovarian carcinoma cells. Bioconjug Chem 2003 Jan-Feb;14(1):44-50

Jensen KD, Kopecková P, Kopecek J, Antisense oligonucleotides delivered to the lysosome escape and actively inhibit the hepatitis B virus. Bioconjug Chem 2002 Sep-Oct;13(5):975-84

Wang D, Pechar M, Li W, Kopecková P, Brömme D, Kopecek J, Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors. Biochemistry 2002 Jul 16;41(28):8849-59

Tang A, Kopecek J, Presentation of epitopes on genetically engineered peptides and selection of lymphoma-targeting moieties based on epitope biorecognition. Biomacromolecules 2002 May-Jun;3(3):421-31

Luo Y, Bernshaw NJ, Lu ZR, Kopecek J, Prestwich GD, Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates. Pharm Res 2002 Apr;19(4):396-402

Kasuya Y, Lu ZR, Kopecková P, Tabibi SE, Kopecek J, Influence of the structure of drug moieties on the in vitro efficacy of HPMA copolymer-geldanamycin derivative conjugates. Pharm Res 2002 Feb;19(2):115-23

Lu ZR, Shiah JG, Sakuma S, Kopecková P, Kopecek J, Design of novel bioconjugates for targeted drug delivery. J Control Release 2002 Jan 17;78(1-3):165-73

Kasuya Y, Lu Z, Kopecková P, Kopecek J, Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems. Bioorg Med Chem Lett 2001 Aug 20;11(16):2089-91

Sakuma S, Lu ZR, Kopecková P, Kopecek J, Biorecognizable HPMA copolymer-drug conjugates for colon-specific delivery of 9-aminocamptothecin. J Control Release 2001 Aug 10;75(3):365-79

Wróblewski S, Berenson M, Kopecková P, Kopecek J, Potential of lectin-N-(2-hydroxypropyl)methacrylamide copolymer-drug conjugates for the treatment of pre-cancerous conditions. J Control Release 2001 Jul 6;74(1-3):283-93

Tijerina M, Kopecková P, Kopecek J, The effects of subcellular localization of N-(2-hydroxypropyl)methacrylamide copolymer-Mce(6) conjugates in a human ovarian carcinoma. J Control Release 2001 Jul 6;74(1-3):269-73

Lu ZR, Shiah JG, Kopecková P, Kopecek J, Preparation and biological evaluation of polymerizable antibody Fab' fragment targeted polymeric drug delivery system. J Control Release 2001 Jul 6;74(1-3):263-8

Shiah JG, Sun Y, Kopecková P, Peterson CM, Straight RC, Kopecek J, Combination chemotherapy and photodynamic therapy of targetable N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin/mesochlorin e(6)-OV-TL 16 antibody immunoconjugates. J Control Release 2001 Jul 6;74(1-3):249-53

Kasuya Y, Lu ZR, Kopecková P, Minko T, Tabibi SE, Kopecek J, Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates. J Control Release 2001 Jul 6;74(1-3):203-11

Kopecek J, Kopecková P, Minko T, Lu ZR, Peterson CM, Water soluble polymers in tumor targeted delivery. J Control Release 2001 Jul 6;74(1-3):147-58

Tang A, Wang C, Stewart RJ, Kopecek J, The coiled coils in the design of protein-based constructs: hybrid hydrogels and epitope displays. J Control Release 2001 May 14;72(1-3):57-70

Minko T, Kopecková P, Kopecek J, Preliminary evaluation of caspases-dependent apoptosis signaling pathways of free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells. J Control Release 2001 Apr 28;71(3):227-37

Wróblewski S, Ríhová B, Rossmann P, Hudcovicz T, Reháková Z, Kopecková P, Kopecek J, The influence of a colonic microbiota on HPMA copolymer lectin conjugates binding in rodent intestine. J Drug Target 2001 Apr;9(2):85-94

Lu ZR, Gao SQ, Kopecková P, Kopecek J, Modification of cyclosporin A and conjugation of its derivative to HPMA copolymers. Bioconjug Chem 2001 Jan-Feb;12(1):129-33

Jensen KD, Kopecková P, Bridge JH, Kopecek J, The cytoplasmic escape and nuclear accumulation of endocytosed and microinjected HPMA copolymers and a basic kinetic study in Hep G2 cells. AAPS PharmSci 2001;3(4):E32

Shiah JG, Dvorák M, Kopecková P, Sun Y, Peterson CM, Kopecek J, Biodistribution and antitumour efficacy of long-circulating N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates in nude mice. Eur J Cancer 2001 Jan;37(1):131-9

Wang C, Kopecek J, Stewart RJ, Hybrid hydrogels cross-linked by genetically engineered coiled-coil block proteins. Biomacromolecules 2001 Fall;2(3):912-20

Fowers KD, Callahan J, Byron P, Kopecek JI, Preparation of Fab' from murine IgG2a for thiol reactive conjugation. J Drug Target 2001;9(4):281-94

Chen L, Kopecek J, Stewart RJ, Responsive hybrid hydrogels with volume transitions modulated by a titin immunoglobulin module. Bioconjug Chem 2000 Sep-Oct;11(5):734-40

Tijerina M, Fowers KD, Kopecková P, Kopecek J, Chronic exposure of human ovarian carcinoma cells to free or HPMA copolymer-bound mesochlorin e6 does not induce P-glycoprotein-mediated multidrug resistance. Biomaterials 2000 Nov;21(21):2203-10

Demoy M, Minko T, Kopecková P, Kopecek J, Time- and concentration-dependent apoptosis and necrosis induced by free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells. J Control Release 2000 Oct 3;69(1):185-96

Wróblewski S, Berenson M, Kopecková P, Kopecek J, Biorecognition of HPMA copolymer-lectin conjugates as an indicator of differentiation of cell-surface glycoproteins in development, maturation, and diseases of human and rodent gastrointestinal tissues. J Biomed Mater Res 2000 Sep 5;51(3):329-42

Tang A, Wang C, Stewart R, Kopecek J, Self-assembled peptides exposing epitopes recognizable by human lymphoma cells. Bioconjug Chem 2000 May-Jun;11(3):363-71

Kopecek J, Kopecková P, Minko T, Lu Z, HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action. Eur J Pharm Biopharm 2000 Jul;50(1):61-81

Minko T, Kopeckova P, Pozharov V, Jensen KD, Kopecek J, The influence of cytotoxicity of macromolecules and of VEGF gene modulated vascular permeability on the enhanced permeability and retention effect in resistant solid tumors. Pharm Res 2000 May;17(5):505-14

Minko T, Kopecková P, Kopecek J, Efficacy of the chemotherapeutic action of HPMA copolymer-bound doxorubicin in a solid tumor model of ovarian carcinoma. Int J Cancer 2000 Apr 1;86(1):108-17

Lu ZR, Gao SQ, Kopecková P, Kopecek J, Synthesis of bioadhesive lectin-HPMA copolymer-cyclosporin conjugates. Bioconjug Chem 2000 Jan-Feb;11(1):3-7

Shiah JG, Sun Y, Peterson CM, Straight RC, Kopecek J, Antitumor activity of N-(2-hydroxypropyl) methacrylamide copolymer-Mesochlorine e6 and adriamycin conjugates in combination treatments. Clin Cancer Res 2000 Mar;6(3):1008-15

Kunath K, Kopecková P, Minko T, Kopecek J, HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. 3. The effect of free and polymer-bound adriamycin on the expression of some genes in the OVCAR-3 human ovarian carcinoma cell line. Eur J Pharm Biopharm 2000 Jan;49(1):11-5

Wang D, Kopecková JP, Minko T, Nanayakkara V, Kopecek J, Synthesis of starlike N-(2-hydroxypropyl)methacrylamide copolymers: potential drug carriers. Biomacromolecules 2000 Fall;1(3):313-9

Hart PR, Kopecková P, Omelyanenko V, Enioutina E, Kopecek J, HPMA copolymer-modified avidin: immune response. J Biomater Sci Polym Ed 2000;11(1):1-12

Lu ZR, Kopecková P, Kopecek J, Polymerizable Fab' antibody fragments for targeting of anticancer drugs. Nat Biotechnol 1999 Nov;17(11):1101-4

Dvorák M, Kopecková P, Kopecek J, High-molecular weight HPMA copolymer-adriamycin conjugates. J Control Release 1999 Aug 5;60(2-3):321-32

Spikes JD, Shen HR, Kopecková P, Kopecek J, Photodynamic crosslinking of proteins. III. Kinetics of the FMN- and rose bengal-sensitized photooxidation and intermolecular crosslinking of model tyrosine-containing N-(2-hydroxypropyl)methacrylamide copolymers. Photochem Photobiol 1999 Aug;70(2):130-7

Omelyanenko V, Kopecková P, Prakash RK, Ebert CD, Kopecek J, Biorecognition of HPMA copolymer-adriamycin conjugates by lymphocytes mediated by synthetic receptor binding epitopes. Pharm Res 1999 Jul;16(7):1010-9

Minko T, Kopecková P, Kopecek J, Comparison of the anticancer effect of free and HPMA copolymer-bound adriamycin in human ovarian carcinoma cells. Pharm Res 1999 Jul;16(7):986-96

Lu JM, Peterson CM, Guo-Shiah J, Gu ZW, Peterson CA, Straight RC, Kopecek J, Cooperativity between free and N-(2-hydroxypropyl) methacrylamide copolymer bound adriamycin and meso-chlorin e6 monoethylene diamine induced photodynamic therapy in human epithelial ovarian carcinoma in vitro. Int J Oncol 1999 Jul;15(1):5-16

Minko T, Kopecková P, Kopecek J, Chronic exposure to HPMA copolymer-bound adriamycin does not induce multidrug resistance in a human ovarian carcinoma cell line. J Control Release 1999 May 20;59(2):133-48

Lu RH, Kopecková P, Kopecek J, Degradation and aggregation of human calcitonin in vitro. Pharm Res 1999 Mar;16(3):359-67

Wang C, Stewart RJ, Kopecek J, Hybrid hydrogels assembled from synthetic polymers and coiled-coil protein domains. Nature 1999 Feb 4;397(6718):417-20

Lu ZR, Kopecková P, Wu Z, Kopecek J, Functionalized semitelechelic poly[N-(2-hydroxypropyl)methacrylamide] for protein modification. Bioconjug Chem 1998 Nov-Dec;9(6):793-804

Minko T, Kopecková P, Pozharov V, Kopecek J, HPMA copolymer bound adriamycin overcomes MDR1 gene encoded resistance in a human ovarian carcinoma cell line. J Control Release 1998 Jul 31;54(2):223-33

Akala EO, Kopecková P, Kopecek J, Novel pH-sensitive hydrogels with adjustable swelling kinetics. Biomaterials 1998 Jun;19(11-12):1037-47

Omelyanenko V, Kopecková P, Gentry C, Kopecek J, Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate. J Control Release 1998 Apr 30;53(1-3):25-37

Omelyanenko V, Gentry C, Kopecková P, Kopecek J, HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. II. Processing in epithelial ovarian carcinoma cells in vitro. Int J Cancer 1998 Feb 9;75(4):600-8

Peterson CM, Lu JM, Gu ZW, Shiah JG, Lythgoe K, Peterson CA, Straight RC, Kopecek J, Isobolographic assessment of the interaction between adriamycin and photodynamic therapy with meso-chlorin e6 monoethylene diamine in human epithelial ovarian carcinoma (OVCAR-3) in vitro. J Soc Gynecol Investig 1995 Nov-Dec;2(6):772-7

Shiah JG, Konák C, Spikes JD, Kopecek J, Influence of pH on aggregation and photoproperties of n-(2-hydroxypropyl)methacrylamide copolymer-meso-chlorin e6 conjugates. Drug Deliv 1998;5(2):119-26

Ghandehari H, Kopecková P, Kopecek J, In vitro degradation of pH-sensitive hydrogels containing aromatic azo bonds. Biomaterials 1997 Jun;18(12):861-72

Chiu HC, Kopecková P, Deshmane SS, Kopecek J, Lysosomal degradability of poly(alpha-amino acids). J Biomed Mater Res 1997 Mar 5;34(3):381-92

Ghandehari H, Smith PL, Ellens H, Yeh PY, Kopecek J, Size-dependent permeability of hydrophilic probes across rabbit colonic epithelium. J Pharmacol Exp Ther 1997 Feb;280(2):747-53

Putnam DA, Shiah JG, Kopecek J, Intracellularly biorecognizable derivatives of 5-fluorouracil. Implications for site-specific delivery in the human condition. Biochem Pharmacol 1996 Sep 27;52(6):957-62

Shen HR, Spikes JD, Kopecková P, Kopecek J, Photodynamic crosslinking of proteins. II. Photocrosslinking of a model protein-ribonuclease A. J Photochem Photobiol B 1996 Sep;35(3):213-9

Peterson CM, Lu JM, Sun Y, Peterson CA, Shiah JG, Straight RC, Kopecek J, Combination chemotherapy and photodynamic therapy with N-(2-hydroxypropyl) methacrylamide copolymer-bound anticancer drugs inhibit human ovarian carcinoma heterotransplanted in nude mice. Cancer Res 1996 Sep 1;56(17):3980-5

Shen HR, Spikes JD, Kopeceková P, Kopecek J, Photodynamic crosslinking of proteins. I. Model studies using histidine- and lysine-containing N-(2-hydroxypropyl)methacrylamide copolymers. J Photochem Photobiol B 1996 Jul;34(2-3):203-10

Omelyanenko V, Kopecková P, Gentry C, Shiah JG, Kopecek J, HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. 1. influence of the method of synthesis on the binding affinity to OVCAR-3 ovarian carcinoma cells in vitro. J Drug Target 1996;3(5):357-73

Putnam D, Kopecek J, Enantioselective release of 5-fluorouracil from N-(2-hydroxypropyl)methacrylamide-based copolymers via lysosomal enzymes. Bioconjug Chem 1995 Jul-Aug;6(4):483-92

Kamei S, Kopecek J, Prolonged blood circulation in rats of nanospheres surface-modified with semitelechelic poly[N-(2-hydroxypropyl)methacrylamide]. Pharm Res 1995 May;12(5):663-8

Yen HR, Oscarsson S, Ulbrich K, Kopecek J, Adsorption and activation of zymogens at solid-liquid interfaces. I. Chymotrypsinogen on alkylamino modified silica derivatives. J Biomed Mater Res 1994 Feb;28(2):247-57

Krinick NL, Sun Y, Joyner D, Spikes JD, Straight RC, Kopecek J, A polymeric drug delivery system for the simultaneous delivery of drugs activatable by enzymes and/or light. J Biomater Sci Polym Ed 1994;5(4):303-24

Chiu HC, Zalipsky S, Kopecková P, Kopecek J, Enzymatic activity of chymotrypsin and its poly(ethylene glycol) conjugates toward low and high molecular weight substrates. Bioconjug Chem 1993 Jul-Aug;4(4):290-5

Brřndsted H, Kopecek J, Hydrogels for site-specific drug delivery to the colon: in vitro and in vivo degradation. Pharm Res 1992 Dec;9(12):1540-5

Brřndsted H, Kopecek J, Hydrogels for site-specific oral drug delivery: synthesis and characterization. Biomaterials 1991 Aug;12(6):584-92

Kopecek J, Targetable polymeric anticancer drugs. Temporal control of drug activity. Ann N Y Acad Sci 1991;618:335-44

Lee JH, Kopeckova P, Kopecek J, Andrade JD, Surface properties of copolymers of alkyl methacrylates with methoxy (polyethylene oxide) methacrylates and their application as protein-resistant coatings. Biomaterials 1990 Sep;11(7):455-64

Lee JH, Kopecek J, Andrade JD, Protein-resistant surfaces prepared by PEO-containing block copolymer surfactants. J Biomed Mater Res 1989 Mar;23(3):351-68

Andrade JD, Herron J, Lin JN, Yen H, Kopecek J, Kopeckova P, On-line sensors for coagulation proteins: concept and progress report. Biomaterials 1988 Jan;9(1):76-9