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Pavla  Kopeckova
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Phone: 801-581-7349
Office: 205 BPR

Pavla Kopeckova

Research Professor of Pharmaceutics and Pharmaceutical Chemistry
Adjunct Professor, Bioengineering

Selected Publications

Pan H, Sima M, Miller SC, Kopecková P, Yang J, Kopecek J, Efficiency of high molecular weight backbone degradable HPMA copolymer-prostaglandin E1 conjugate in promotion of bone formation in ovariectomized rats. Biomaterials 2013 Sep;34(27):6528-38

Liu J, Kopecková P, Pan H, Sima M, Bühler P, Wolf P, Elsässer-Beile U, Kopecek J, Prostate-cancer-targeted N-(2-hydroxypropyl)methacrylamide copolymer/docetaxel conjugates. Macromol Biosci 2012 Mar;12(3):412-22

Johnson RN, Kopecková P, Kopecek J, Biological activity of anti-CD20 multivalent HPMA copolymer-Fab' conjugates. Biomacromolecules 2012 Mar 12;13(3):727-35

Luo K, Yang J, Kopecková P, Kopecek J, Biodegradable Multiblock Poly[N-(2-hydroxypropyl)methacrylamide] via Reversible Addition-Fragmentation Chain Transfer Polymerization and Click Chemistry. Macromolecules 2011 Apr 26;44(8):2481-2488

Yang J, Luo K, Pan H, Kopecková P, Kopecek J, Synthesis of Biodegradable Multiblock Copolymers by Click Coupling of RAFT-Generated HeterotelechelicPolyHPMA Conjugates. React Funct Polym 2011 Mar 1;71(3):294-302

Pan H, Yang J, Kopecková P, Kopecek J, Backbone degradable multiblock N-(2-hydroxypropyl)methacrylamide copolymer conjugates via reversible addition-fragmentation chain transfer polymerization and thiol-ene coupling reaction. Biomacromolecules 2011 Jan 10;12(1):247-52

Giantsos-Adams K, Lopez-Quintero V, Kopeckova P, Kopecek J, Tarbell JM, Dull R, Study of the therapeutic benefit of cationic copolymer administration to vascular endothelium under mechanical stress. Biomaterials 2011 Jan;32(1):288-94

Liu J, Bauer H, Callahan J, Kopecková P, Pan H, Kopecek J, Endocytic uptake of a large array of HPMA copolymers: Elucidation into the dependence on the physicochemical characteristics. J Control Release 2010 Apr 2;143(1):71-9

Kopecek J, Kopecková P, HPMA copolymers: origins, early developments, present, and future. Adv Drug Deliv Rev 2010 Feb 17;62(2):122-49

Gao SQ, Sun Y, Kopecková P, Peterson CM, Kopecek J, Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts. Macromol Biosci 2009 Nov 10;9(11):1135-42

Giantsos KM, Kopeckova P, Dull RO, The use of an endothelium-targeted cationic copolymer to enhance the barrier function of lung capillary endothelial monolayers. Biomaterials 2009 Oct;30(29):5885-91

Callahan J, Kopec?kova´ P, Kopec?ek J, Intracellular Trafficking and Subcellular Distribution of a Large Array of HPMA Copolymers. Biomacromolecules 2009 Jul 13;10(7):1704-1714

Liu J, Kopecková P, Bühler P, Wolf P, Pan H, Bauer H, Elsässer-Beile U, Kopecek J, Biorecognition and subcellular trafficking of HPMA copolymer-anti-PSMA antibody conjugates by prostate cancer cells. Mol Pharm 2009 May-Jun;6(3):959-70

Johnson RN, Kopecková P, Kopecek J, Synthesis and evaluation of multivalent branched HPMA copolymer-Fab' conjugates targeted to the B-cell antigen CD20. Bioconjug Chem 2009 Jan;20(1):129-37

Miller SC, Pan H, Wang D, Bowman BM, Kopecková P, Kopecek J, Feasibility of using a bone-targeted, macromolecular delivery system coupled with prostaglandin E(1) to promote bone formation in aged, estrogen-deficient rats. Pharm Res 2008 Dec;25(12):2889-95

Yuan W, Yang J, Kopecková P, Kopecek J, Smart hydrogels containing adenylate kinase: translating substrate recognition into macroscopic motion. J Am Chem Soc 2008 Nov 26;130(47):15760-1

Hongrapipat J, Kopecková P, Liu J, Prakongpan S, Kopecek J, Combination chemotherapy and photodynamic therapy with fab' fragment targeted HPMA copolymer conjugates in human ovarian carcinoma cells. Mol Pharm 2008 Sep-Oct;5(5):696-709

Cuchelkar V, Kopecková P, Kopecek J, Novel HPMA copolymer-bound constructs for combined tumor and mitochondrial targeting. Mol Pharm 2008 Sep-Oct;5(5):776-86

Pan H, Sima M, Kopecková P, Wu K, Gao S, Liu J, Wang D, Miller SC, Kopecek J, Biodistribution and pharmacokinetic studies of bone-targeting N-(2-hydroxypropyl)methacrylamide copolymer-alendronate conjugates. Mol Pharm 2008 Jul-Aug;5(4):548-58

Pan H, Liu J, Dong Y, Sima M, Kopecková P, Brandi ML, Kopecek J, Release of prostaglandin E(1) from N-(2-hydroxypropyl)methacrylamide copolymer conjugates by bone cells. Macromol Biosci 2008 Jul 7;8(7):599-605

Cuchelkar V, Kopecková P, Kopecek J, Synthesis and biological evaluation of disulfide-linked HPMA copolymer-mesochlorin e6 conjugates. Macromol Biosci 2008 May 13;8(5):375-83

Hongrapipat J, Kopecková P, Prakongpan S, Kopecek J, Enhanced antitumor activity of combinations of free and HPMA copolymer-bound drugs. Int J Pharm 2008 Mar 3;351(1-2):259-70

Gao SQ, Sun Y, Kopecková P, Peterson CM, Kopecek J, Pharmacokinetic modeling of absorption behavior of 9-aminocamptothecin (9-AC) released from colon-specific HPMA copolymer-9-AC conjugate in rats. Pharm Res 2008 Jan;25(1):218-26

Pan H, Kopecková P, Liu J, Wang D, Miller SC, Kopecek J, Stability in plasmas of various species of HPMA copolymer-PGE1 conjugates. Pharm Res 2007 Dec;24(12):2270-80

Malugin A, Kopecková P, Kopecek J, Liberation of doxorubicin from HPMA copolymer conjugate is essential for the induction of cell cycle arrest and nuclear fragmentation in ovarian carcinoma cells. J Control Release 2007 Dec 4;124(1-2):6-10

Ding H, Kopecková P, Kopecek J, Self-association properties of HPMA copolymers containing an amphipathic heptapeptide. J Drug Target 2007 Aug-Sep;15(7-8):465-74

Wang D, Miller SC, Shlyakhtenko LS, Portillo AM, Liu XM, Papangkorn K, Kopeckova P, Lyubchenko Y, Higuchi WI, Kopecek , Osteotropic Peptide That Differentiates Functional Domains of the Skeleton. Bioconjug Chem 2007 Aug 17;:

Gao SQ, Lu ZR, Kopecková P, Kopecek J, Biodistribution and pharmacokinetics of colon-specific HPMA copolymer--9-aminocamptothecin conjugate in mice. J Control Release 2007 Feb 12;117(2):179-85

Wang D, Sima M, Mosley RL, Davda JP, Tietze N, Miller SC, Gwilt PR, Kopecková P, Kopecek J, Pharmacokinetic and biodistribution studies of a bone-targeting drug delivery system based on N-(2-hydroxypropyl)methacrylamide copolymers. Mol Pharm 2006 Nov-Dec;3(6):717-25

Pan H, Kopeckova P, Wang D, Yang J, Miller S, Kopecek , Water-soluble HPMA copolymer-prostaglandin E1 conjugates containing a cathepsin K sensitive spacer. J Drug Target 2006 Jul;14(6):425-35

Pan H, Kopecková P, Wang D, Yang J, Miller S, Kopecek J, Water-soluble HPMA copolymer--prostaglandin E1 conjugates containing a cathepsin K sensitive spacer. J Drug Target 2006 Jul;14(6):425-35

Malugin A, Kopecková P, Kopecek J, HPMA copolymer-bound doxorubicin induces apoptosis in ovarian carcinoma cells by the disruption of mitochondrial function. Mol Pharm 2006 May-Jun;3(3):351-61

Yang J, Xu C, Kopecková P, Kopecek J, Hybrid hydrogels self-assembled from HPMA copolymers containing peptide grafts. Macromol Biosci 2006 Mar 14;6(3):201-9

Chivukula P, Dusek K, Wang D, Dusková-Smrcková M, Kopecková P, Kopecek J, Synthesis and characterization of novel aromatic azo bond-containing pH-sensitive and hydrolytically cleavable IPN hydrogels. Biomaterials 2006 Mar;27(7):1140-51

Gao SQ, Lu ZR, Petri B, Kopecková P, Kopecek J, Colon-specific 9-aminocamptothecin-HPMA copolymer conjugates containing a 1,6-elimination spacer. J Control Release 2006 Jan 10;110(2):323-31

Malugin A, Kopecková P, Kopecek J, HPMA copolymer-bound doxorubicin induces apoptosis in human ovarian carcinoma cells by a Fas-independent pathway. Mol Pharm 2004 May-Jun;1(3):174-82

Wang D, Miller SC, Kopecková P, Kopecek J, Bone-targeting macromolecular therapeutics. Adv Drug Deliv Rev 2005 May 25;57(7):1049-76

Miller SC, Wang D, Kopecková P, Kopecek J, Biopolymer-based delivery systems for advanced imaging and skeletal tissue-specific therapeutics. J Bone Miner Metab 2005;23 Suppl:103-8

Wang D, Miller SC, Sima M, Parker D, Buswell H, Goodrich KC, Kopecková P, Kopecek J, The arthrotropism of macromolecules in adjuvant-induced arthritis rat model: a preliminary study. Pharm Res 2004 Oct;21(10):1741-9

Wang D, Li W, Pechar M, Kopecková P, Brömme D, Kopecek J, Cathepsin K inhibitor-polymer conjugates: potential drugs for the treatment of osteoporosis and rheumatoid arthritis. Int J Pharm 2004 Jun 11;277(1-2):73-9

Nishiyama N, Nori A, Malugin A, Kasuya Y, Kopecková P, Kopecek J, Free and N-(2-hydroxypropyl)methacrylamide copolymer-bound geldanamycin derivative induce different stress responses in A2780 human ovarian carcinoma cells. Cancer Res 2003 Nov 15;63(22):7876-82

Merdan T, Callahan J, Petersen H, Kunath K, Bakowsky U, Kopecková P, Kissel T, Kopecek J, Pegylated polyethylenimine-Fab' antibody fragment conjugates for targeted gene delivery to human ovarian carcinoma cells. Bioconjug Chem 2003 Sep-Oct;14(5):989-96

Wang D, Miller S, Sima M, Kopecková P, Kopecek J, Synthesis and evaluation of water-soluble polymeric bone-targeted drug delivery systems. Bioconjug Chem 2003 Sep-Oct;14(5):853-9

Tijerina M, Kopecková P, Kopecek J, Mechanisms of cytotoxicity in human ovarian carcinoma cells exposed to free Mce6 or HPMA copolymer-Mce6 conjugates. Photochem Photobiol 2003 Jun;77(6):645-52

Tijerina M, Kopecková P, Kopecek J, Correlation of subcellular compartmentalization of HPMA copolymer-Mce6 conjugates with chemotherapeutic activity in human ovarian carcinoma cells. Pharm Res 2003 May;20(5):728-37

Jensen KD, Nori A, Tijerina M, Kopecková P, Kopecek J, Cytoplasmic delivery and nuclear targeting of synthetic macromolecules. J Control Release 2003 Feb 21;87(1-3):89-105

Peterson CM, Shiah JG, Sun Y, Kopecková P, Minko T, Straight RC, Kopecek J, HPMA copolymer delivery of chemotherapy and photodynamic therapy in ovarian cancer. Adv Exp Med Biol 2003;519:101-23

Nori A, Jensen KD, Tijerina M, Kopecková P, Kopecek J, Tat-conjugated synthetic macromolecules facilitate cytoplasmic drug delivery to human ovarian carcinoma cells. Bioconjug Chem 2003 Jan-Feb;14(1):44-50

Jensen KD, Kopecková P, Kopecek J, Antisense oligonucleotides delivered to the lysosome escape and actively inhibit the hepatitis B virus. Bioconjug Chem 2002 Sep-Oct;13(5):975-84

Wang D, Pechar M, Li W, Kopecková P, Brömme D, Kopecek J, Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors. Biochemistry 2002 Jul 16;41(28):8849-59

Kasuya Y, Lu ZR, Kopecková P, Tabibi SE, Kopecek J, Influence of the structure of drug moieties on the in vitro efficacy of HPMA copolymer-geldanamycin derivative conjugates. Pharm Res 2002 Feb;19(2):115-23

Lu ZR, Shiah JG, Sakuma S, Kopecková P, Kopecek J, Design of novel bioconjugates for targeted drug delivery. J Control Release 2002 Jan 17;78(1-3):165-73

Sakuma S, Lu ZR, Kopecková P, Kopecek J, Biorecognizable HPMA copolymer-drug conjugates for colon-specific delivery of 9-aminocamptothecin. J Control Release 2001 Aug 10;75(3):365-79

Kasuya Y, Lu Z, Kopecková P, Kopecek J, Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems. Bioorg Med Chem Lett 2001 Aug 20;11(16):2089-91

Kopecek J, Kopecková P, Minko T, Lu ZR, Peterson CM, Water soluble polymers in tumor targeted delivery. J Control Release 2001 Jul 6;74(1-3):147-58

Tijerina M, Kopecková P, Kopecek J, The effects of subcellular localization of N-(2-hydroxypropyl)methacrylamide copolymer-Mce(6) conjugates in a human ovarian carcinoma. J Control Release 2001 Jul 6;74(1-3):269-73

Wróblewski S, Berenson M, Kopecková P, Kopecek J, Potential of lectin-N-(2-hydroxypropyl)methacrylamide copolymer-drug conjugates for the treatment of pre-cancerous conditions. J Control Release 2001 Jul 6;74(1-3):283-93

Lu ZR, Shiah JG, Kopecková P, Kopecek J, Preparation and biological evaluation of polymerizable antibody Fab' fragment targeted polymeric drug delivery system. J Control Release 2001 Jul 6;74(1-3):263-8

Shiah JG, Sun Y, Kopecková P, Peterson CM, Straight RC, Kopecek J, Combination chemotherapy and photodynamic therapy of targetable N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin/mesochlorin e(6)-OV-TL 16 antibody immunoconjugates. J Control Release 2001 Jul 6;74(1-3):249-53

Kasuya Y, Lu ZR, Kopecková P, Minko T, Tabibi SE, Kopecek J, Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates. J Control Release 2001 Jul 6;74(1-3):203-11

Wróblewski S, Ríhová B, Rossmann P, Hudcovicz T, Reháková Z, Kopecková P, Kopecek J, The influence of a colonic microbiota on HPMA copolymer lectin conjugates binding in rodent intestine. J Drug Target 2001 Apr;9(2):85-94

Minko T, Kopecková P, Kopecek J, Preliminary evaluation of caspases-dependent apoptosis signaling pathways of free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells. J Control Release 2001 Apr 28;71(3):227-37

Lu ZR, Gao SQ, Kopecková P, Kopecek J, Modification of cyclosporin A and conjugation of its derivative to HPMA copolymers. Bioconjug Chem 2001 Jan-Feb;12(1):129-33

Jensen KD, Kopecková P, Bridge JH, Kopecek J, The cytoplasmic escape and nuclear accumulation of endocytosed and microinjected HPMA copolymers and a basic kinetic study in Hep G2 cells. AAPS PharmSci 2001;3(4):E32

Shiah JG, Dvorák M, Kopecková P, Sun Y, Peterson CM, Kopecek J, Biodistribution and antitumour efficacy of long-circulating N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates in nude mice. Eur J Cancer 2001 Jan;37(1):131-9

Tijerina M, Fowers KD, Kopecková P, Kopecek J, Chronic exposure of human ovarian carcinoma cells to free or HPMA copolymer-bound mesochlorin e6 does not induce P-glycoprotein-mediated multidrug resistance. Biomaterials 2000 Nov;21(21):2203-10

Demoy M, Minko T, Kopecková P, Kopecek J, Time- and concentration-dependent apoptosis and necrosis induced by free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells. J Control Release 2000 Oct 3;69(1):185-96

Wróblewski S, Berenson M, Kopecková P, Kopecek J, Biorecognition of HPMA copolymer-lectin conjugates as an indicator of differentiation of cell-surface glycoproteins in development, maturation, and diseases of human and rodent gastrointestinal tissues. J Biomed Mater Res 2000 Sep 5;51(3):329-42

Kopecek J, Kopecková P, Minko T, Lu Z, HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action. Eur J Pharm Biopharm 2000 Jul;50(1):61-81

Minko T, Kopeckova P, Pozharov V, Jensen KD, Kopecek J, The influence of cytotoxicity of macromolecules and of VEGF gene modulated vascular permeability on the enhanced permeability and retention effect in resistant solid tumors. Pharm Res 2000 May;17(5):505-14

Minko T, Kopecková P, Kopecek J, Efficacy of the chemotherapeutic action of HPMA copolymer-bound doxorubicin in a solid tumor model of ovarian carcinoma. Int J Cancer 2000 Apr 1;86(1):108-17

Lu ZR, Gao SQ, Kopecková P, Kopecek J, Synthesis of bioadhesive lectin-HPMA copolymer-cyclosporin conjugates. Bioconjug Chem 2000 Jan-Feb;11(1):3-7

Kunath K, Kopecková P, Minko T, Kopecek J, HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. 3. The effect of free and polymer-bound adriamycin on the expression of some genes in the OVCAR-3 human ovarian carcinoma cell line. Eur J Pharm Biopharm 2000 Jan;49(1):11-5

Hart PR, Kopecková P, Omelyanenko V, Enioutina E, Kopecek J, HPMA copolymer-modified avidin: immune response. J Biomater Sci Polym Ed 2000;11(1):1-12

Lu ZR, Kopecková P, Kopecek J, Polymerizable Fab' antibody fragments for targeting of anticancer drugs. Nat Biotechnol 1999 Nov;17(11):1101-4

Dvorák M, Kopecková P, Kopecek J, High-molecular weight HPMA copolymer-adriamycin conjugates. J Control Release 1999 Aug 5;60(2-3):321-32

Spikes JD, Shen HR, Kopecková P, Kopecek J, Photodynamic crosslinking of proteins. III. Kinetics of the FMN- and rose bengal-sensitized photooxidation and intermolecular crosslinking of model tyrosine-containing N-(2-hydroxypropyl)methacrylamide copolymers. Photochem Photobiol 1999 Aug;70(2):130-7

Minko T, Kopecková P, Kopecek J, Comparison of the anticancer effect of free and HPMA copolymer-bound adriamycin in human ovarian carcinoma cells. Pharm Res 1999 Jul;16(7):986-96

Omelyanenko V, Kopecková P, Prakash RK, Ebert CD, Kopecek J, Biorecognition of HPMA copolymer-adriamycin conjugates by lymphocytes mediated by synthetic receptor binding epitopes. Pharm Res 1999 Jul;16(7):1010-9

Minko T, Kopecková P, Kopecek J, Chronic exposure to HPMA copolymer-bound adriamycin does not induce multidrug resistance in a human ovarian carcinoma cell line. J Control Release 1999 May 20;59(2):133-48

Lu RH, Kopecková P, Kopecek J, Degradation and aggregation of human calcitonin in vitro. Pharm Res 1999 Mar;16(3):359-67

Lu ZR, Kopecková P, Wu Z, Kopecek J, Functionalized semitelechelic poly[N-(2-hydroxypropyl)methacrylamide] for protein modification. Bioconjug Chem 1998 Nov-Dec;9(6):793-804

Minko T, Kopecková P, Pozharov V, Kopecek J, HPMA copolymer bound adriamycin overcomes MDR1 gene encoded resistance in a human ovarian carcinoma cell line. J Control Release 1998 Jul 31;54(2):223-33

Akala EO, Kopecková P, Kopecek J, Novel pH-sensitive hydrogels with adjustable swelling kinetics. Biomaterials 1998 Jun;19(11-12):1037-47

Omelyanenko V, Kopecková P, Gentry C, Kopecek J, Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate. J Control Release 1998 Apr 30;53(1-3):25-37

Omelyanenko V, Gentry C, Kopecková P, Kopecek J, HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. II. Processing in epithelial ovarian carcinoma cells in vitro. Int J Cancer 1998 Feb 9;75(4):600-8

Ghandehari H, Kopecková P, Kopecek J, In vitro degradation of pH-sensitive hydrogels containing aromatic azo bonds. Biomaterials 1997 Jun;18(12):861-72

Chiu HC, Kopecková P, Deshmane SS, Kopecek J, Lysosomal degradability of poly(alpha-amino acids). J Biomed Mater Res 1997 Mar 5;34(3):381-92

Shen HR, Spikes JD, Kopecková P, Kopecek J, Photodynamic crosslinking of proteins. II. Photocrosslinking of a model protein-ribonuclease A. J Photochem Photobiol B 1996 Sep;35(3):213-9

Omelyanenko V, Kopecková P, Gentry C, Shiah JG, Kopecek J, HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. 1. influence of the method of synthesis on the binding affinity to OVCAR-3 ovarian carcinoma cells in vitro. J Drug Target 1996;3(5):357-73

Chiu HC, Zalipsky S, Kopecková P, Kopecek J, Enzymatic activity of chymotrypsin and its poly(ethylene glycol) conjugates toward low and high molecular weight substrates. Bioconjug Chem 1993 Jul-Aug;4(4):290-5

Lee JH, Kopeckova P, Kopecek J, Andrade JD, Surface properties of copolymers of alkyl methacrylates with methoxy (polyethylene oxide) methacrylates and their application as protein-resistant coatings. Biomaterials 1990 Sep;11(7):455-64

Andrade JD, Herron J, Lin JN, Yen H, Kopecek J, Kopeckova P, On-line sensors for coagulation proteins: concept and progress report. Biomaterials 1988 Jan;9(1):76-9