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You H. Bae

Phone: (801) 585-1518
Office: 421 Wakara Way, 315

You H. Bae

Professor of Pharmaceutical Chemistry
Adjunct Professor, Bioengineering

Selected Publications

Nurunnabi M, Lee SA, Revuri V, Hwang YH, Kang SH, Lee M, Cho S, Cho KJ, Byun Y, Bae YH, Lee DY, Lee YK, Oral delivery of a therapeutic gene encoding glucagon-like peptide 1 to treat high fat diet-induced diabetes. J Control Release 2017 Aug 28;:

Nichols JW, Sakurai Y, Harashima H, Bae YH, Nano-sized drug carriers: Extravasation, intratumoral distribution, and their modeling. J Control Release 2017 Aug 11;:

Huang W, Chen L, Kang L, Jin M, Sun P, Xin X, Gao Z, Bae YH, Nanomedicine-based combination anticancer therapy between nucleic acids and small-molecular drugs. Adv Drug Deliv Rev 2017 Jun 1;115:82-97

Cho H, Cho YW, Kang SW, Kwak MK, Huh KM, Bae YH, Kang HC, Tempo-spatial Activation of Sequential Quadruple Stimuli for High Gene Expression of Polymeric Gene Nanocomplexes. Mol Pharm 2017 Mar 6;14(3):842-855

Fan B, Kang L, Chen L, Sun P, Jin M, Wang Q, Bae YH, Huang W, Gao Z, Systemic siRNA Delivery with a Dual pH-Responsive and Tumor-targeted Nanovector for Inhibiting Tumor Growth and Spontaneous Metastasis in Orthotopic Murine Model of Breast Carcinoma. Theranostics 2017;7(2):357-376

Choi YS, Cho DY, Lee HK, Cho JK, Lee DH, Bae YH, Lee JK, Kang HC, Enhanced cell survival of pH-sensitive bioenergetic nucleotide nanoparticles in energy/oxygen-depleted cells and their intranasal delivery for reduced brain infarction. Acta Biomater 2016 Sep 1;41:147-60

Suzuki H, Bae YH, Evaluation of drug penetration with cationic micelles and their penetration mechanism using an in vitro tumor model. Biomaterials 2016 Aug;98:120-30

Matsumoto Y, Nichols JW, Toh K, Nomoto T, Cabral H, Miura Y, Christie RJ, Yamada N, Ogura T, Kano MR, Matsumura Y, Nishiyama N, Yamasoba T, Bae YH, Kataoka K, Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery. Nat Nanotechnol 2016 Jun;11(6):533-8

Stirland DL, Matsumoto Y, Toh K, Kataoka K, Bae YH, Analyzing spatiotemporal distribution of uniquely fluorescent nanoparticles in xenograft tumors. J Control Release 2016 Apr 10;227:38-44

Choi JW, Dayananda K, Jung SJ, Lee SH, Kim D, Hu J, Bae YH, Yun CO, Enhanced anti-tumor efficacy and safety profile of tumor microenvironment-responsive oncolytic adenovirus nanocomplex by systemic administration. Acta Biomater 2015 Dec;28:86-98

Grainger DW, Bae YH, The 17th International Symposium on Recent Advances in Drug Delivery, June 14-17, 2015, Salt Lake City, UT, USA. Preface. J Control Release 2015 Dec 28;220(Pt B):569-70

Park H, Cho S, Janat-Amsbury MM, Bae YH, Enhanced thermogenic program by non-viral delivery of combinatory browning genes to treat diet-induced obesity in mice. Biomaterials 2015 Dec;73:32-41

Cho H, Lee YJ, Bae YH, Kang HC, Synthetic polynucleotides as endosomolytic agents and bioenergy sources. J Control Release 2015 Oct 28;216:30-6

Stirland DL, Nichols JW, Jarboe E, Adelman M, Dassel M, Janát-Amsbury MM, Bae YH, Uterine perfusion model for analyzing barriers to transport in fibroids. J Control Release 2015 Sep 28;214:85-93

Kang HC, Cho H, Bae YH, DNA Polyplexes as Combinatory Drug Carriers of Doxorubicin and Cisplatin: An in Vitro Study. Mol Pharm 2015 Aug 3;12(8):2845-57

Park H, Cho S, Han YH, Janat-Amsbury MM, Boudina S, Bae YH, Combinatorial gene construct and non-viral delivery for anti-obesity in diet-induced obese mice. J Control Release 2015 Jun 10;207:154-62

Choi JW, Jung SJ, Kasala D, Hwang JK, Hu J, Bae YH, Yun CO, pH-sensitive oncolytic adenovirus hybrid targeting acidic tumor microenvironment and angiogenesis. J Control Release 2015 May 10;205:134-43

Cho S, Park H, Jarboe EA, Peterson CM, Bae YH, Janát-Amsbury MM, Design and Characterization of Bioengineered Cancer-Like Stem Cells. PLoS One 2015;10(10):e0141172

Park JW, Kim SJ, Kwag DS, Kim S, Park J, Youn YS, Bae YH, Lee ES, Multifunctional Delivery Systems for Advanced oral Uptake of Peptide/Protein Drugs. Curr Pharm Des 2015;21(22):3097-110

Miura S, Suzuki H, Bae YH, A Multilayered Cell Culture Model for Transport Study in Solid Tumors: Evaluation of Tissue Penetration of Polyethyleneimine Based Cationic Micelles. Nano Today 2014 Dec 1;9(6):695-704

Hwang HS, Hu J, Na K, Bae YH, Role of polymeric endosomolytic agents in gene transfection: a comparative study of poly(L-lysine) grafted with monomeric L-histidine analogue and poly(L-histidine). Biomacromolecules 2014 Oct 13;15(10):3577-86

Nichols JW, Bae YH, EPR: Evidence and fallacy. J Control Release 2014 Sep 28;190:451-64

Mishra D, Kang HC, Cho H, Bae YH, Dexamethasone-loaded reconstitutable charged polymeric (PLGA)n -b-bPEI micelles for enhanced nuclear delivery of gene therapeutics. Macromol Biosci 2014 Jun;14(6):831-41

Yin H, Kang HC, Huh KM, Bae YH, Effects of cholesterol incorporation on the physicochemical, colloidal, and biological characteristics of pH-sensitive AB2 miktoarm polymer-based polymersomes. Colloids Surf B Biointerfaces 2014 Apr 1;116:128-37

Khatun Z, Nurunnabi, Cho KJ, Byun Y, Bae YH, Lee YK, Oral absorption mechanism and anti-angiogenesis effect of taurocholic acid-linked heparin-docetaxel conjugates. J Control Release 2014 Mar 10;177:64-73

Stirland DL, Nichols JW, Miura S, Bae YH, Mind the gap: a survey of how cancer drug carriers are susceptible to the gap between research and practice. J Control Release 2013 Dec 28;172(3):1045-64

Bae YH, Grainger DW, The 16th International Symposium on Recent Advances in Drug Delivery, February 3-6, 2013, Salt Lake City, UT, USA. J Control Release 2013 Dec 10;172(2):393-4

Hu J, Miura S, Na K, Bae YH, pH-responsive and charge shielded cationic micelle of poly(L-histidine)-block-short branched PEI for acidic cancer treatment. J Control Release 2013 Nov 28;172(1):69-76

Tian L, Kang HC, Bae YH, Endosomolytic reducible polymeric electrolytes for cytosolic protein delivery. Biomacromolecules 2013 Aug 12;14(8):2570-81

Hwang HS, Kang HC, Bae YH, Bioreducible polymers as a determining factor for polyplex decomplexation rate and transfection. Biomacromolecules 2013 Feb 11;14(2):548-56

Nichols JW, Bae YH, Odyssey of a cancer nanoparticle: from injection site to site of action. Nano Today 2012 Dec 1;7(6):606-618

Park W, Kim D, Kang HC, Bae YH, Na K, Multi-arm histidine copolymer for controlled release of insulin from poly(lactide-co-glycolide) microsphere. Biomaterials 2012 Dec;33(34):8848-57

Denison TA, Bae YH, Tumor heterogeneity and its implication for drug delivery. J Control Release 2012 Dec 10;164(2):187-91

Tian L, Bae YH, Cancer nanomedicines targeting tumor extracellular pH. Colloids Surf B Biointerfaces 2012 Nov 1;99:116-26

Yin H, Kang HC, Huh KM, Bae YH, Biocompatible, pH-sensitive AB(2) Miktoarm Polymer-Based Polymersomes: Preparation, Characterization, and Acidic pH-Activated Nanostructural Transformation. J Mater Chem 2012 Sep 28;22(36):91968-19178

Lee YJ, Kang HC, Hu J, Nichols JW, Jeon YS, Bae YH, pH-Sensitive polymeric micelle-based pH probe for detecting and imaging acidic biological environments. Biomacromolecules 2012 Sep 10;13(9):2945-51

Nadithe V, Mishra D, Bae YH, Poly(ethylene glycol) cross-linked hemoglobin with antioxidant enzymes protects pancreatic islets from hypoxic and free radical stress and extends islet functionality. Biotechnol Bioeng 2012 Sep;109(9):2392-401

Kang HC, Lee JE, Bae YH, Nanoscaled buffering zone of charged (PLGA)n-b-bPEI micelles in acidic microclimate for potential protein delivery application. J Control Release 2012 Jun 28;160(3):440-50

Kang HC, Samsonova O, Kang SW, Bae YH, The effect of environmental pH on polymeric transfection efficiency. Biomaterials 2012 Feb;33(5):1651-62

Nadithe V, Bae YH, Hemoglobin conjugates with antioxidant enzymes (hemoglobin-superoxide dismutase-catalase) via poly(ethylene glycol) crosslinker for protection of pancreatic beta RINm5F cells in hypoxia. Tissue Eng Part A 2011 Oct;17(19-20):2453-62

Bae YH, Apoptosis-targeted drug delivery. J Control Release 2011 Sep 25;154(3):213

Bae YH, Park K, Targeted drug delivery to tumors: myths, reality and possibility. J Control Release 2011 Aug 10;153(3):198-205

Chang Kang H, Bae YH, Co-delivery of small interfering RNA and plasmid DNA using a polymeric vector incorporating endosomolytic oligomeric sulfonamide. Biomaterials 2011 Jul;32(21):4914-24

Mishra D, Kang HC, Bae YH, Reconstitutable charged polymeric (PLGA)(2)-b-PEI micelles for gene therapeutics delivery. Biomaterials 2011 May;32(15):3845-54

Gao ZG, Tian L, Hu J, Park IS, Bae YH, Prevention of metastasis in a 4T1 murine breast cancer model by doxorubicin carried by folate conjugated pH sensitive polymeric micelles. J Control Release 2011 May 30;152(1):84-9

Bae YH, Intravital real-time confocal laser scanning imaging of PEGylated gene vectors. J Control Release 2011 Apr 30;151(2):103

Kang HC, Kang HJ, Bae YH, A reducible polycationic gene vector derived from thiolated low molecular weight branched polyethyleneimine linked by 2-iminothiolane. Biomaterials 2011 Feb;32(4):1193-203

Nadithe V, Bae YH, Synthesis and characterization of hemoglobin conjugates with antioxidant enzymes via poly(ethylene glycol) cross-linker (Hb-SOD-CAT) for protection from free radical stress. Int J Biol Macromol 2010 Dec 1;47(5):603-13

Maeng JH, Lee DH, Jung KH, Bae YH, Park IS, Jeong S, Jeon YS, Shim CK, Kim W, Kim J, Lee J, Lee YM, Kim JH, Kim WH, Hong SS, Multifunctional doxorubicin loaded superparamagnetic iron oxide nanoparticles for chemotherapy and magnetic resonance imaging in liver cancer. Biomaterials 2010 Jun;31(18):4995-5006

Kang HC, Samsonova O, Bae YH, Trafficking microenvironmental pHs of polycationic gene vectors in drug-sensitive and multidrug-resistant MCF7 breast cancer cells. Biomaterials 2010 Apr;31(11):3071-8

Park K, Bae YH, Grainger DW, The 14th International Symposium on Recent Advances in Drug Delivery Systems, February 15-18, 2009, Salt Lake City, UT, USA. J Control Release 2009 Dec 16;140(3):183-4

Kim D, Gao ZG, Lee ES, Bae YH, In vivo evaluation of doxorubicin-loaded polymeric micelles targeting folate receptors and early endosomal pH in drug-resistant ovarian cancer. Mol Pharm 2009 Sep-Oct;6(5):1353-62

Kang SW, Bae YH, Cryopreservable and tumorigenic three-dimensional tumor culture in porous poly(lactic-co-glycolic acid) microsphere. Biomaterials 2009 Sep;30(25):4227-32

Kang HC, Bae YH, Transfection of rat pancreatic islet tissue by polymeric gene vectors. Diabetes Technol Ther 2009 Jul;11(7):443-9

Kang HC, Bae YH, Transfection of insulin-secreting cell line and rat islets by functional polymeric gene vector. Biomaterials 2009 May;30(14):2837-45

Yin H, Bae YH, Physicochemical aspects of doxorubicin-loaded pH-sensitive polymeric micelle formulations from a mixture of poly(L-histidine)-b-poly(ethylene glycol)/poly(L-lactide)-b-poly(ethylene glycol) [corrected]. Eur J Pharm Biopharm 2009 Feb;71(2):223-30

Bae YH, Drug targeting and tumor heterogeneity. J Control Release 2009 Jan 5;133(1):2-3

Lee ES, Gao Z, Bae YH, Recent progress in tumor pH targeting nanotechnology. J Control Release 2008 Dec 18;132(3):164-70

Kim D, Lee ES, Oh KT, Gao ZG, Bae YH, Doxorubicin-loaded polymeric micelle overcomes multidrug resistance of cancer by double-targeting folate receptor and early endosomal pH. Small 2008 Nov;4(11):2043-50

Bae YH, Yin H, Stability issues of polymeric micelles. J Control Release 2008 Oct 6;131(1):2-4

Kim D, Lee ES, Park K, Kwon IC, Bae YH, Doxorubicin loaded pH-sensitive micelle: antitumoral efficacy against ovarian A2780/DOXR tumor. Pharm Res 2008 Sep;25(9):2074-82

Lee ES, Gao Z, Kim D, Park K, Kwon IC, Bae YH, Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance. J Control Release 2008 Aug 7;129(3):228-36

Oh KT, Lee ES, Kim D, Bae YH, L-histidine-based pH-sensitive anticancer drug carrier micelle: reconstitution and brief evaluation of its systemic toxicity. Int J Pharm 2008 Jun 24;358(1-2):177-83

Taluja A, Bae YH, Role of a novel multifunctional excipient poly(ethylene glycol)-block-oligo(vinyl sulfadimethoxine) in controlled release of lysozyme from PLGA microspheres. Int J Pharm 2008 Jun 24;358(1-2):50-9

Yin H, Lee ES, Kim D, Lee KH, Oh KT, Bae YH, Physicochemical characteristics of pH-sensitive poly(L-histidine)-b-poly(ethylene glycol)/poly(L-lactide)-b-poly(ethylene glycol) mixed micelles. J Control Release 2008 Mar 3;126(2):130-8

Sethuraman VA, Lee MC, Bae YH, A biodegradable pH-sensitive micelle system for targeting acidic solid tumors. Pharm Res 2008 Mar;25(3):657-66

Qiu LY, Bae YH, Self-assembled polyethylenimine-graft-poly(epsilon-caprolactone) micelles as potential dual carriers of genes and anticancer drugs. Biomaterials 2007 Oct;28(28):4132-42

Lee ES, Oh KT, Kim D, Youn YS, Bae YH, Tumor pH-responsive flower-like micelles of poly(L-lactic acid)-b-poly(ethylene glycol)-b-poly(L-histidine). J Control Release 2007 Oct 18;123(1):19-26

Mohajer G, Lee ES, Bae YH, Enhanced intercellular retention activity of novel pH-sensitive polymeric micelles in wild and multidrug resistant MCF-7 cells. Pharm Res 2007 Sep;24(9):1618-27

Taluja A, Bae YH, Role of a novel excipient poly(ethylene glycol)-b-poly(L-histidine) in retention of physical stability of insulin at aqueous/organic interface. Mol Pharm 2007 Jul-Aug;4(4):561-70

Taluja A, Bae YH, Role of a novel excipient poly(ethylene glycol)-b-poly(L-histidine) in retention of physical stability of insulin in aqueous solutions. Pharm Res 2007 Aug;24(8):1517-26

Sethuraman VA, Bae YH, TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors. J Control Release 2007 Apr 2;118(2):216-24

Kang HC, Bae YH, Polymeric gene transfection on insulin-secreting cells: sulfonylurea receptor-mediation and transfection medium effect. Pharm Res 2006 Aug;23(8):1797-808

Zhu W, Masaki T, Bae YH, Rathi R, Cheung AK, Kern SE, Development of a sustained-release system for perivascular delivery of dipyridamole. J Biomed Mater Res B Appl Biomater 2006 Apr;77(1):135-43

Sethuraman VA, Na K, Bae YH, pH-responsive sulfonamide/PEI system for tumor specific gene delivery: an in vitro study. Biomacromolecules 2006 Jan;7(1):64-70

Qiu LY, Bae YH, Polymer architecture and drug delivery. Pharm Res 2006 Jan;23(1):1-30

Gao ZG, Lee DH, Kim DI, Bae YH, Doxorubicin loaded pH-sensitive micelle targeting acidic extracellular pH of human ovarian A2780 tumor in mice. J Drug Target 2005 Aug;13(7):391-7

Kang HC, Kim S, Lee M, Bae YH, Polymeric gene carrier for insulin secreting cells: poly(L-lysine)-g-sulfonylurea for receptor mediated transfection. J Control Release 2005 Jun 20;105(1-2):164-76

Kim S, Wan Kim S, Bae YH, Synthesis, bioactivity and specificity of glucagon-like peptide-1 (7-37)/polymer conjugate to isolated rat islets. Biomaterials 2005 Jun;26(17):3597-606

Lee ES, Na K, Bae YH, Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor. J Control Release 2005 Mar 21;103(2):405-18

Lee ES, Na K, Bae YH, Super pH-sensitive multifunctional polymeric micelle. Nano Lett 2005 Feb;5(2):325-9

Kim S, Bae YH, Long-term insulinotropic activity of glucagon-like peptide-1/polymer conjugate on islet microcapsules. Tissue Eng 2004 Nov-Dec;10(11-12):1607-16

Kang HC, Lee M, Bae YH, Polymeric gene carriers. Crit Rev Eukaryot Gene Expr 2005;15(4):317-42

Chae SY, Kim YY, Kim SW, Bae YH, Prolonged glucose normalization of streptozotocin-induced diabetic mice by transplantation of rat islets coencapsulated with crosslinked hemoglobin. Transplantation 2004 Aug 15;78(3):392-7

Na K, Lee KH, Bae YH, pH-sensitivity and pH-dependent interior structural change of self-assembled hydrogel nanoparticles of pullulan acetate/oligo-sulfonamide conjugate. J Control Release 2004 Jul 7;97(3):513-25

Bae YH, Caged pancreatic islet for IDDM. Yonsei Med J 2004 Jun 30;45 Suppl:56-60

Kim S, Bae YH, Visual evidence and quantification of interaction of polymeric sulfonylurea with pancreatic islet. Biomacromolecules 2003 Nov-Dec;4(6):1550-7

Lee ES, Na K, Bae YH, Polymeric micelle for tumor pH and folate-mediated targeting. J Control Release 2003 Aug 28;91(1-2):103-13

Lee ES, Shin HJ, Na K, Bae YH, Poly(L-histidine)-PEG block copolymer micelles and pH-induced destabilization. J Control Release 2003 Jul 31;90(3):363-74

Na K, Lee ES, Bae YH, Adriamycin loaded pullulan acetate/sulfonamide conjugate nanoparticles responding to tumor pH: pH-dependent cell interaction, internalization and cytotoxicity in vitro. J Control Release 2003 Feb 21;87(1-3):3-13

Ahn CH, Chae SY, Bae YH, Kim SW, Biodegradable poly(ethylenimine) for plasmid DNA delivery. J Control Release 2002 Apr 23;80(1-3):273-82

Gappa H, Baudys M, Koh JJ, Kim SW, Bae YH, The effect of zinc-crystallized glucagon-like peptide-1 on insulin secretion of macroencapsulated pancreatic islets. Tissue Eng 2001 Feb;7(1):35-44

Chae SY, Kim SW, Bae YH, Bioactive polymers for biohybrid artificial pancreas. J Drug Target 2001;9(6):473-84

Vernon B, Kim SW, Bae YH, Thermoreversible copolymer gels for extracellular matrix. J Biomed Mater Res 2000 Jul;51(1):69-79

Jeong B, Bae YH, Kim SW, In situ gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions and degradation thereof. J Biomed Mater Res 2000 May;50(2):171-7

Jeong B, Bae YH, Kim SW, Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers. J Control Release 2000 Jan 3;63(1-2):155-63

Jeong B, Choi YK, Bae YH, Zentner G, Kim SW, New biodegradable polymers for injectable drug delivery systems. J Control Release 1999 Nov 1;62(1-2):109-14

Vernon B, Kim SW, Bae YH, Insulin release from islets of Langerhans entrapped in a poly(N-isopropylacrylamide-co-acrylic acid) polymer gel. J Biomater Sci Polym Ed 1999;10(2):183-98

Jeong B, Bae YH, Lee DS, Kim SW, Biodegradable block copolymers as injectable drug-delivery systems. Nature 1997 Aug 28;388(6645):860-2

Gutowska A, Bae YH, Jacobs H, Mohammad F, Mix D, Feijen J, Kim SW, Heparin release from thermosensitive polymer coatings: in vivo studies. J Biomed Mater Res 1995 Jul;29(7):811-21

Yang Y, Jacobs H, Bae YH, Kim SW, Selective protein transport through a thin cellulose coated porous membrane. Biotechnol Bioeng 1994 Feb 5;43(3):207-14

Pai CM, Jacobs H, Bae YH, Kim SW, Synthesis and characterization of soluble concanavalin A oligomer. Biotechnol Bioeng 1993 Apr 25;41(10):957-63

Pai CM, Bae YH, Mack EJ, Wilson DE, Kim SW, Concanavalin A microspheres for a self-regulating insulin delivery system. J Pharm Sci 1992 Jun;81(6):532-6

Kim SW, Bae YH, Okano T, Hydrogels: swelling, drug loading, and release. Pharm Res 1992 Mar;9(3):283-90

Kwon IC, Bae YH, Kim SW, Electrically erodible polymer gel for controlled release of drugs. Nature 1991 Nov 28;354(6351):291-3

Bae YH, Okano T, Kim SW, "On-off" thermocontrol of solute transport. II. Solute release from thermosensitive hydrogels. Pharm Res 1991 May;8(5):624-8

Bae YH, Okano T, Kim SW, "On-off" thermocontrol of solute transport. I. Temperature dependence of swelling of N-isopropylacrylamide networks modified with hydrophobic components in water. Pharm Res 1991 Apr;8(4):531-7