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Brenda  Mann

Phone: 8014416521
Office: 391 Chipeta Way, Suite H

Brenda Mann

Vice President for R&D, EyeGate Pharmaceuticals
Co-founder, Sentrx Animal Care
Registered Patent Agent
BS, Chemical Engineering, Iowa State University
PhD, Chemical Engineering, Rice University
Postdoc, Bioengineering, Rice University


Cellular and Tissue Engineering, Biomaterials

Current Research

Development of synthetic extracellular matrices for medical devices and tissue engineering
Development of cellular microarrays for drug toxicity testing
Stereolithography of hydrogel scaffolds for tissue engineering
Examining cellular response to different hydrogel microenvironments

Below are some selected additional publications that are not listed in the PubMed "Selected Publications" collection (at the bottom of this page):

Prestwich GD, Mann BK. Creating commercial value from biomaterials. In Translational Regenerative Medicine. Atala A, Allickson J, eds. Elsevier, 2015; pp 185-195.
Yang G, Prestwich GD, Mann BK. Thiolated carboxymethyl hyaluronic acid-based biomaterials enhance wound healing in rats, dogs, and horses. ISRN Veterinary Science, Volume 2011, Article ID 851593, 7 pages.
Arcaute K, Mann BK, Wicker RB. Fabrication of Off-the-Shelf Multi-Lumen Poly(ethylene glycol) Nerve Guidance Conduits Using Stereolithography. Tissue Engineering, Part C: Methods 2011; 17:27-38.
Mann BK, Turner SD. Glycoproteins and adhesion peptides: properties and biomedical applications. In Renewable Resources for Functional Polymers and Biomaterials: Polysaccharides, Proteins and Polyesters. Williams PA, ed. Royal Society of Chemistry, London, 2011.
Arcaute K, Mann BK, Wicker RB. Stereolithography of spatially-controlled multi-material bioactive poly(ethylene glycol) scaffolds. Acta Biomaterialia 2010; 6:1047-1054.
Arcaute K, Mann BK, Wicker RB. Practical use of hydrogels in stereolithography for tissue engineering applications. In Stereolithography: Materials, Processes and Applications. Bartolo P, ed. Springer, New York, 2009.
Masters KS, Mann BK. Tissue engineered heart. In Applications of Cell Immobilisation Biotechnology. Nedovic V, Willaert R, eds. Springer, 2005.
Arcaute K, Ochoa L, Medina F, Elkins C, Mann B, Wicker R. Three-dimensional PEG hydrogel construct fabrication using stereolithography. Materials Research Society Symposium Proceedings 2005; 874:L5.5.1-7.
Fernet MD, Melvin B, Gustin MC, Shanks JV. 13C-NMR studies of glucose metabolism in osmolarity mutants of Saccharomyces cerevisiae. Enzyme and Microbial Technology 1994; 16:207-15.

Selected Publications

Williams DL, Wirostko BM, Gum G, Mann BK, Topical Cross-Linked HA-Based Hydrogel Accelerates Closure of Corneal Epithelial Defects and Repair of Stromal Ulceration in Companion Animals. Invest Ophthalmol Vis Sci 2017 Sep 1;58(11):4616-4622

Jann HW, Hart JC, Stein LE, Ritchey J, Blaik M, Payton M, Fackelman GE, Rezabek GB, Mann BK, The Effects of a Crosslinked, Modified Hyaluronic Acid (xCMHA-S) Gel on Equine Tendon Healing. Vet Surg 2016 Feb;45(2):231-9

Wendling RJ, Christensen AM, Quast AD, Atzet SK, Mann BK, Effect of Carboxymethylation on the Rheological Properties of Hyaluronan. PLoS One 2016;11(9):e0162849

Evangelista MS, Perez M, Salibian AA, Hassan JM, Darcy S, Paydar KZ, Wicker RB, Arcaute K, Mann BK, Evans GR, Single-lumen and multi-lumen poly(ethylene glycol) nerve conduits fabricated by stereolithography for peripheral nerve regeneration in vivo. J Reconstr Microsurg 2015 Jun;31(5):327-35

Astashkina AI, Mann BK, Prestwich GD, Grainger DW, 'Erratum to "Comparing predictive drug nephrotoxicity biomarkers in kidney 3-D primary organoid culture and immortalized cell lines" [Biomaterials 33 (2012) 4712-4721]'. Biomaterials 2015 Jan;38:108

Wirostko B, Mann BK, Williams DL, Prestwich GD, Ophthalmic Uses of a Thiol-Modified Hyaluronan-Based Hydrogel. Adv Wound Care (New Rochelle) 2014 Nov 1;3(11):708-716

Williams DL, Mann BK, Efficacy of a crosslinked hyaluronic acid-based hydrogel as a tear film supplement: a masked controlled study. PLoS One 2014;9(6):e99766

Williams DL, Mann BK, A Crosslinked HA-Based Hydrogel Ameliorates Dry Eye Symptoms in Dogs. Int J Biomater 2013;2013:460437

Astashkina AI, Mann BK, Prestwich GD, Grainger DW, A 3-D organoid kidney culture model engineered for high-throughput nephrotoxicity assays. Biomaterials 2012 Jun;33(18):4700-11

Astashkina AI, Mann BK, Prestwich GD, Grainger DW, Comparing predictive drug nephrotoxicity biomarkers in kidney 3-D primary organoid culture and immortalized cell lines. Biomaterials 2012 Jun;33(18):4712-21

Astashkina A, Mann B, Grainger DW, A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity. Pharmacol Ther 2012 Apr;134(1):82-106

Lawyer T, McIntosh K, Clavijo C, Potekhina L, Mann BK, Formulation Changes Affect Material Properties and Cell Behavior in HA-Based Hydrogels. Int J Cell Biol 2012;2012:737421

Yang G, Prestwich GD, Mann BK, Thiolated carboxymethyl-hyaluronic-Acid-based biomaterials enhance wound healing in rats, dogs, and horses. ISRN Vet Sci 2011;2011:851593

Baird IS, Yau AY, Mann BK, Mammalian cell-seeded hydrogel microarrays printed via dip-pin technology. Biotechniques 2008 Feb;44(2):249-56

Vanderhooft JL, Mann BK, Prestwich GD, Synthesis and characterization of novel thiol-reactive poly(ethylene glycol) cross-linkers for extracellular-matrix-mimetic biomaterials. Biomacromolecules 2007 Sep;8(9):2883-9

Arcaute K, Mann BK, Wicker RB, Stereolithography of three-dimensional bioactive poly(ethylene glycol) constructs with encapsulated cells. Ann Biomed Eng 2006 Sep;34(9):1429-41

Gunn JW, Turner SD, Mann B , Adhesive and mechanical properties of hydrogels influence neurite extension. J Biomed Mater Res A 2005 Jan 1;72(1):91-7

Mann BK, Biologic gels in tissue engineering. Clin Plast Surg 2003 Oct;30(4):601-9

Mann BK, West J , Cell adhesion peptides alter smooth muscle cell adhesion, proliferation, migration, and matrix protein synthesis on modified surfaces and in polymer scaffolds. J Biomed Mater Res 2002 Apr;60(1):86-93

Mann BK, Gobin AS, Tsai AT, Schmedlen RH, West J , Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering. Biomaterials 2001 Nov;22(22):3045-51

Mann BK, West J , Tissue engineering in the cardiovascular system: progress toward a tissue engineered heart. Anat Rec 2001 Aug 1;263(4):367-71

Mann BK, Schmedlen RH, West J , Tethered-TGF-beta increases extracellular matrix production of vascular smooth muscle cells. Biomaterials 2001 Mar;22(5):439-44

Mann BK, Tsai AT, Scott-Burden T, West J , Modification of surfaces with cell adhesion peptides alters extracellular matrix deposition. Biomaterials 1999 Dec;20(23-24):2281-6

Melvin BK, Shanks J , Influence of aeration on cytoplasmic pH of yeast in an NMR airlift bioreactor. Biotechnol Prog 1996 Mar-Apr;12(2):257-65