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Glenn D. Prestwich

Phone: 801-585-9501
Office: Medicinal Chem,419 Wakara Ste 205

Glenn D. Prestwich

Professor of Medicinal Chemistry
Adjunct Professor, Bioengineering

Selected Publications

Jensen MM, Jia W, Isaacson KJ, Schults A, Cappello J, Prestwich GD, Oottamasathien S, Ghandehari H, Silk-elastinlike protein polymers enhance the efficacy of a therapeutic glycosaminoglycan for prophylactic treatment of radiation-induced proctitis. J Control Release 2017 Oct 10;263:46-56

Pulsipher A, Qin X, Thomas AJ, Prestwich GD, Oottamasathien S, Alt JA, Prevention of sinonasal inflammation by a synthetic glycosaminoglycan. Int Forum Allergy Rhinol 2017 Feb;7(2):177-184

Dormán G, Nakamura H, Pulsipher A, Prestwich GD, The Life of Pi Star: Exploring the Exciting and Forbidden Worlds of the Benzophenone Photophore. Chem Rev 2016 Dec 28;116(24):15284-15398

Stock AJ, Kasus-Jacobi A, Wren JD, Sjoelund VH, Prestwich GD, Pereira HA, The Role of Neutrophil Proteins on the Amyloid Beta-RAGE Axis. PLoS One 2016;11(9):e0163330

Ryskamp DA, Frye AM, Phuong TT, Yarishkin O, Jo AO, Xu Y, Lakk M, Iuso A, Redmon SN, Ambati B, Hageman G, Prestwich GD, Torrejon KY, Križaj D, TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye. Sci Rep 2016 Aug 11;6:30583

Highley CB, Prestwich GD, Burdick JA, Recent advances in hyaluronic acid hydrogels for biomedical applications. Curr Opin Biotechnol 2016 Aug;40:35-40

Savage JR, Pulsipher A, Rao NV, Kennedy TP, Prestwich GD, Ryan ME, Lee WY, A Modified Glycosaminoglycan, GM-0111, Inhibits Molecular Signaling Involved in Periodontitis. PLoS One 2016;11(6):e0157310

Alt JA, Qin X, Pulsipher A, Orb Q, Orlandi RR, Zhang J, Schults A, Jia W, Presson AP, Prestwich GD, Oottamasathien S, Topical cathelicidin (LL-37) an innate immune peptide induces acute olfactory epithelium inflammation in a mouse model. Int Forum Allergy Rhinol 2015 Dec;5(12):1141-50

Murph MM, Jiang GW, Altman MK, Jia W, Nguyen DT, Fambrough JM, Hardman WJ, Nguyen HT, Tran SK, Alshamrani AA, Madan D, Zhang J, Prestwich GD, Vinyl sulfone analogs of lysophosphatidylcholine irreversibly inhibit autotaxin and prevent angiogenesis in melanoma. Bioorg Med Chem 2015 Sep 1;23(17):5999-6013

Woodman JL, Suh MS, Zhang J, Kondaveeti Y, Burgess DJ, White BA, Prestwich GD, Kuhn LT, Carboxymethyl Hyaluronan-Stabilized Nanoparticles for Anticancer Drug Delivery. Int J Cell Biol 2015;2015:249573

Astashkina AI, Mann BK, Prestwich GD, Grainger DW, 'Erratum to "Comparing predictive drug nephrotoxicity biomarkers in kidney 3-D primary organoid culture and immortalized cell lines" [Biomaterials 33 (2012) 4712-4721]'. Biomaterials 2015 Jan;38:108

Prestwich GD, Healy KE, Why regenerative medicine needs an extracellular matrix. Expert Opin Biol Ther 2015 Jan;15(1):3-7

Skindersoe ME, Krogfelt KA, Blom A, Zhang J, Jiang G, Prestwich GD, Mansell JP, Dual Action of Lysophosphatidate-Functionalised Titanium: Interactions with Human (MG63) Osteoblasts and Methicillin Resistant Staphylococcus aureus. PLoS One 2015;10(11):e0143509

Mouratis MA, Magkrioti C, Oikonomou N, Katsifa A, Prestwich GD, Kaffe E, Aidinis V, Autotaxin and Endotoxin-Induced Acute Lung Injury. PLoS One 2015;10(7):e0133619

Wirostko B, Mann BK, Williams DL, Prestwich GD, Ophthalmic Uses of a Thiol-Modified Hyaluronan-Based Hydrogel. Adv Wound Care (New Rochelle) 2014 Nov 1;3(11):708-716

Prestwich GD, Delivery, retention and engraftment of progenitor cells in cell therapy. Biomatter 2013 Jan-Mar;3(1):

Zhuo R, Kosak KM, Sankar S, Wiles ET, Sun Y, Zhang J, Ayello J, Prestwich GD, Shami PJ, Cairo MS, Lessnick SL, Luo W, Targeting Glutathione S-transferase M4 in Ewing sarcoma. Front Pediatr 2014;2:83

Oottamasathien S, Jia W, Roundy LM, Zhang J, Wang L, Ye X, Hill AC, Savage J, Lee WY, Hannon AM, Milner S, Prestwich GD, Physiological relevance of LL-37 induced bladder inflammation and mast cells. J Urol 2013 Oct;190(4 Suppl):1596-1602

Swarup VP, Hsiao TW, Zhang J, Prestwich GD, Kuberan B, Hlady V, Exploiting differential surface display of chondroitin sulfate variants for directing neuronal outgrowth. J Am Chem Soc 2013 Sep 11;135(36):13488-94

Roundy LM, Jia W, Zhang J, Ye X, Prestwich GD, Oottamasathien S, LL-37 induced cystitis and the receptor for advanced glycation end-products (RAGE) pathway. Adv Biosci Biotechnol 2013 Aug 1;4(8B):1-8

Park AH, Hoyt D, Britt D, Chase S, Tansavatdi K, Hunter L, McGill L, Sheng X, Skardal A, Prestwich GD, Cross-linked hydrogel and polyester resorbable ventilation tubes in a Chinchilla model. Laryngoscope 2013 Apr;123(4):1043-8

Jiang G, Inoue A, Aoki J, Prestwich GD, Phosphorothioate analogs of sn-2 radyl lysophosphatidic acid (LPA): metabolically stabilized LPA receptor agonists. Bioorg Med Chem Lett 2013 Mar 15;23(6):1865-9

Prestwich GD, Culture of impact: faculty as mentors for student entrepreneurs. Sci Transl Med 2013 Jan 23;5(169):169ed2

Lee WY, Savage JR, Zhang J, Jia W, Oottamasathien S, Prestwich GD, Prevention of anti-microbial peptide LL-37-induced apoptosis and ATP release in the urinary bladder by a modified glycosaminoglycan. PLoS One 2013;8(10):e77854

Madan D, Ferguson CG, Lee WY, Prestwich GD, Testa CA, Non-invasive imaging of tumors by monitoring autotaxin activity using an enzyme-activated near-infrared fluorogenic substrate. PLoS One 2013;8(11):e79065

Prestwich GD, Erickson IE, Zarembinski TI, West M, Tew WP, The translational imperative: making cell therapy simple and effective. Acta Biomater 2012 Dec;8(12):4200-7

Prestwich GD, Bhatia S, Breuer CK, Dahl SL, Mason C, McFarland R, McQuillan DJ, Sackner-Bernstein J, Schox J, Tente WE, Trounson A, What is the greatest regulatory challenge in the translation of biomaterials to the clinic? Sci Transl Med 2012 Nov 14;4(160):160cm14

Astashkina AI, Mann BK, Prestwich GD, Grainger DW, Comparing predictive drug nephrotoxicity biomarkers in kidney 3-D primary organoid culture and immortalized cell lines. Biomaterials 2012 Jun;33(18):4712-21

Astashkina AI, Mann BK, Prestwich GD, Grainger DW, A 3-D organoid kidney culture model engineered for high-throughput nephrotoxicity assays. Biomaterials 2012 Jun;33(18):4700-11

Oottamasathien S, Jia W, McCoard L, Slack S, Zhang J, Skardal A, Job K, Kennedy TP, Dull RO, Prestwich GD, A murine model of inflammatory bladder disease: cathelicidin peptide induced bladder inflammation and treatment with sulfated polysaccharides. J Urol 2011 Oct;186(4 Suppl):1684-92

Prestwich GD, Hyaluronic acid-based clinical biomaterials derived for cell and molecule delivery in regenerative medicine. J Control Release 2011 Oct 30;155(2):193-9

Jiang G, Madan D, Prestwich GD, Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin. Bioorg Med Chem Lett 2011 Sep 1;21(17):5098-101

Zhang J, Xu X, Rao NV, Argyle B, McCoard L, Rusho WJ, Kennedy TP, Prestwich GD, Krueger G, Novel sulfated polysaccharides disrupt cathelicidins, inhibit RAGE and reduce cutaneous inflammation in a mouse model of rosacea. PLoS One 2011 Feb 9;6(2):e16658

Yang G, Prestwich GD, Mann BK, Thiolated carboxymethyl-hyaluronic-Acid-based biomaterials enhance wound healing in rats, dogs, and horses. ISRN Vet Sci 2011;2011:851593

Skardal A, Sarker SF, Crabbé A, Nickerson CA, Prestwich GD, The generation of 3-D tissue models based on hyaluronan hydrogel-coated microcarriers within a rotating wall vessel bioreactor. Biomaterials 2010 Nov;31(32):8426-35

Skardal A, Zhang J, McCoard L, Oottamasathien S, Prestwich GD, Dynamically crosslinked gold nanoparticle - hyaluronan hydrogels. Adv Mater 2010 Nov 9;22(42):4736-40

Skardal A, Zhang J, Prestwich GD, Bioprinting vessel-like constructs using hyaluronan hydrogels crosslinked with tetrahedral polyethylene glycol tetracrylates. Biomaterials 2010 Aug;31(24):6173-81

Skardal A, Zhang J, McCoard L, Xu X, Oottamasathien S, Prestwich GD, Photocrosslinkable hyaluronan-gelatin hydrogels for two-step bioprinting. Tissue Eng Part A 2010 Aug;16(8):2675-85

Rao NV, Argyle B, Xu X, Reynolds PR, Walenga JM, Prechel M, Prestwich GD, MacArthur RB, Walters BB, Hoidal JR, Kennedy TP, Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands. Am J Physiol Cell Physiol 2010 Jul;299(1):C97-110

Xu X, Prestwich GD, Inhibition of tumor growth and angiogenesis by a lysophosphatidic acid antagonist in an engineered three-dimensional lung cancer xenograft model. Cancer 2010 Apr 1;116(7):1739-50

Zhang H, He J, Kutateladze TG, Sakai T, Sasaki T, Markadieu N, Erneux C, Prestwich GD, 5-Stabilized phosphatidylinositol 3,4,5-trisphosphate analogues bind Grp1 PH, inhibit phosphoinositide phosphatases, and block neutrophil migration. Chembiochem 2010 Feb 15;11(3):388-95

Xu X, Yang G, Zhang H, Prestwich GD, Evaluating dual activity LPA receptor pan-antagonist/autotaxin inhibitors as anti-cancer agents in vivo using engineered human tumors. Prostaglandins Other Lipid Mediat 2009 Sep;89(3-4):140-6

Zhang H, Xu X, Gajewiak J, Tsukahara R, Fujiwara Y, Liu J, Fells JI, Perygin D, Parrill AL, Tigyi G, Prestwich GD, Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. Cancer Res 2009 Jul 1;69(13):5441-9

Zhang H, Thompson J, Prestwich GD, A scalable synthesis of the IP7 isomer, 5-PP-Ins(1,2,3,4,6)P5. Org Lett 2009 Apr 2;11(7):1551-4

Vanderhooft JL, Alcoutlabi M, Magda JJ, Prestwich GD, Rheological properties of cross-linked hyaluronan-gelatin hydrogels for tissue engineering. Macromol Biosci 2009 Jan 9;9(1):20-8

Zhang J, Skardal A, Prestwich GD, Engineered extracellular matrices with cleavable crosslinkers for cell expansion and easy cell recovery. Biomaterials 2008 Dec;29(34):4521-31

Serban MA, Scott A, Prestwich GD, Use of hyaluronan-derived hydrogels for three-dimensional cell culture and tumor xenografts. Curr Protoc Cell Biol 2008 Sep;Chapter 10:Unit 10.14

Prestwich GD, Gajewiak J, Zhang H, Xu X, Yang G, Serban M, Phosphatase-resistant analogues of lysophosphatidic acid: agonists promote healing, antagonists and autotaxin inhibitors treat cancer. Biochim Biophys Acta 2008 Sep;1781(9):588-94

Prestwich GD, Kuo JW, Chemically-modified HA for therapy and regenerative medicine. Curr Pharm Biotechnol 2008 Aug;9(4):242-5

Scaife CL, Shea JE, Dai Q, Firpo MA, Prestwich GD, Mulvihill SJ, Synthetic extracellular matrix enhances tumor growth and metastasis in an orthotopic mouse model of pancreatic adenocarcinoma. J Gastrointest Surg 2008 Jun;12(6):1074-80

Serban MA, Prestwich GD, Modular extracellular matrices: solutions for the puzzle. Methods 2008 May;45(1):93-8

Liu Y, Skardal A, Shu XZ, Prestwich GD, Prevention of peritendinous adhesions using a hyaluronan-derived hydrogel film following partial-thickness flexor tendon injury. J Orthop Res 2008 Apr;26(4):562-9

Serban MA, Yang G, Prestwich GD, Synthesis, characterization and chondroprotective properties of a hyaluronan thioethyl ether derivative. Biomaterials 2008 Apr;29(10):1388-99

Gajewiak J, Tsukahara R, Fujiwara Y, Tigyi G, Prestwich GD, Synthesis, pharmacology, and cell biology of sn-2-aminooxy analogues of lysophosphatidic acid. Org Lett 2008 Mar 20;10(6):1111-4

Prestwich GD, Evaluating drug efficacy and toxicology in three dimensions: using synthetic extracellular matrices in drug discovery. Acc Chem Res 2008 Jan;41(1):139-48

Prestwich GD, Engineering a clinically-useful matrix for cell therapy. Organogenesis 2008 Jan;4(1):42-7

Serban MA, Liu Y, Prestwich GD, Effects of extracellular matrix analogues on primary human fibroblast behavior. Acta Biomater 2008 Jan;4(1):67-75

Zhang H, Xu Y, Markadieu N, Beauwens R, Erneux C, Prestwich GD, Synthesis and biological activity of phosphatidylinositol-3,4,5-trisphosphorothioate. Bioorg Med Chem Lett 2008 Jan 15;18(2):762-6

Gajewiak J, Tsukahara R, Tsukahara T, Fujiwara Y, Yu S, Lu Y, Murph M, Mills GB, Tigyi G, Prestwich GD, Alkoxymethylenephosphonate analogues of (Lyso) phosphatidic acid stimulate signaling networks coupled to the LPA2 receptor. ChemMedChem 2007 Dec;2(12):1789-98

Serban MA, Prestwich GD, Synthesis of hyaluronan haloacetates and biology of novel cross-linker-free synthetic extracellular matrix hydrogels. Biomacromolecules 2007 Sep;8(9):2821-8

Vanderhooft JL, Mann BK, Prestwich GD, Synthesis and characterization of novel thiol-reactive poly(ethylene glycol) cross-linkers for extracellular-matrix-mimetic biomaterials. Biomacromolecules 2007 Sep;8(9):2883-9

Zhang L, Huang W, Tanimura A, Morita T, Harihar S, Dewald DB, Prestwich GD, Synthesis and biological activity of metabolically stabilized cyclopentyl trisphosphate analogues of D-myo-Ins(1,4,5)P3. ChemMedChem 2007 Sep;2(9):1281-9

Liu Y, Shu XZ, Prestwich G , Reply: A statistical correction is in order. Fertil Steril 2007 Aug 4;:

Prestwich GD, Simplifying the extracellular matrix for 3-D cell culture and tissue engineering: a pragmatic approach. J Cell Biochem 2007 Aug 15;101(6):1370-83

Orlandi RR, Shu XZ, McGill L, Petersen E, Prestwich GD, Structural variations in a single hyaluronan derivative significantly alter wound-healing effects in the rabbit maxillary sinus. Laryngoscope 2007 Jul;117(7):1288-95

Connors RC, Muir JJ, Liu Y, Reiss GR, Kouretas PC, Whitten MG, Sorenson TK, Prestwich GD, Bull DA, Postoperative pericardial adhesion prevention using Carbylan-SX in a rabbit model. J Surg Res 2007 Jun 15;140(2):237-42

Huang W, Zhang H, Davrazou F, Kutateladze TG, Shi X, Gozani O, Prestwich GD, Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling. J Am Chem Soc 2007 May 23;129(20):6498-506

Jiang G, Xu Y, Fujiwara Y, Tsukahara T, Tsukahara R, Gajewiak J, Tigyi G, Prestwich GD, Alpha-substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPA. ChemMedChem 2007 May;2(5):679-90

Liu Y, Shu XZ, Prestwich GD, Tumor engineering: orthotopic cancer models in mice using cell-loaded, injectable, cross-linked hyaluronan-derived hydrogels. Tissue Eng 2007 May;13(5):1091-101

Liu Y, Shu XZ, Prestwich GD, Reduced postoperative intra-abdominal adhesions using Carbylan-SX, a semisynthetic glycosaminoglycan hydrogel. Fertil Steril 2007 Apr;87(4):940-8

Liu Y, Cai S, Shu XZ, Shelby J, Prestwich GD, Release of basic fibroblast growth factor from a crosslinked glycosaminoglycan hydrogel promotes wound healing. Wound Repair Regen 2007 Mar-Apr;15(2):245-51

Prestwich GD, Liu Y, Yu B, Shu XZ, Scott A, 3-D culture in synthetic extracellular matrices: new tissue models for drug toxicology and cancer drug discovery. Adv Enzyme Regul 2007;47:196-207

Shu XZ, Ahmad S, Liu Y, Prestwich GD, Synthesis and evaluation of injectable, in situ crosslinkable synthetic extracellular matrices for tissue engineering. J Biomed Mater Res A 2006 Dec 15;79(4):902-12

Zhang H, Markadieu N, Beauwens R, Erneux C, Prestwich GD, Synthesis and biological activity of PTEN-resistant analogues of phosphatidylinositol 3,4,5-trisphosphate. J Am Chem Soc 2006 Dec 27;128(51):16464-5

Park AH, Hughes CW, Jackson A, Hunter L, McGill L, Simonsen SE, Alder SC, Shu XZ, Prestwich GD, Crosslinked hydrogels for tympanic membrane repair. Otolaryngol Head Neck Surg 2006 Dec;135(6):877-83

Liu Y, Shu XZ, Prestwich GD, Osteochondral defect repair with autologous bone marrow-derived mesenchymal stem cells in an injectable, in situ, cross-linked synthetic extracellular matrix. Tissue Eng 2006 Dec;12(12):3405-16

Liu Y, Shu XZ, Prestwich G , Osteochondral Defect Repair with Autologous Bone Marrow-Derived Mesenchymal Stem Cells in an Injectable, In Situ, Cross-Linked Synthetic Extracellular Matrix. Tissue Eng 2006 Oct 1;:

Xu Y, Jiang G, Tsukahara R, Fujiwara Y, Tigyi G, Prestwich GD, Phosphonothioate and fluoromethylene phosphonate analogues of cyclic phosphatidic acid: Novel antagonists of lysophosphatidic acid receptors. J Med Chem 2006 Aug 24;49(17):5309-15

Zhang H, Tsukuhara R, Tigyi G, Prestwich GD, Synthesis of cyclic phosphonate analogues of (lyso)phosphatidic acid using a ring-closing metathesis reaction. J Org Chem 2006 Aug 4;71(16):6061-6

Sondrup C, Liu Y, Shu XZ, Prestwich GD, Smith ME, Cross-linked hyaluronan-coated stents in the prevention of airway stenosis. Otolaryngol Head Neck Surg 2006 Jul;135(1):28-35

Liu Y, Ahmad S, Shu XZ, Sanders RK, Kopesec SA, Prestwich GD, Accelerated repair of cortical bone defects using a synthetic extracellular matrix to deliver human demineralized bone matrix. J Orthop Res 2006 Jul;24(7):1454-62

Gajewiak J, Cai S, Shu XZ, Prestwich GD, Aminooxy pluronics: synthesis and preparation of glycosaminoglycan adducts. Biomacromolecules 2006 Jun;7(6):1781-9

Rose TM, Prestwich GD, Synthesis and evaluation of fluorogenic substrates for phospholipase D and phospholipase C. Org Lett 2006 Jun 8;8(12):2575-8

Gajewiak J, Xu Y, Lee SA, Kutateladze TG, Prestwich GD, Synthesis and molecular recognition of phosphatidylinositol-3-methylenephosphate. Org Lett 2006 Jun 22;8(13):2811-3

Zhang H, Xu Y, Zhang Z, Liman ER, Prestwich GD, Synthesis and biological activity of phospholipase C-resistant analogues of phosphatidylinositol 4,5-bisphosphate. J Am Chem Soc 2006 May 3;128(17):5642-3

Ferguson CG, Bigman CS, Richardson RD, van Meeteren LA, Moolenaar WH, Prestwich GD, Fluorogenic phospholipid substrate to detect lysophospholipase D/autotaxin activity. Org Lett 2006 May 11;8(10):2023-6

Proctor M, Proctor K, Shu XZ, McGill LD, Prestwich GD, Orlandi RR, Composition of hyaluronan affects wound healing in the rabbit maxillary sinus. Am J Rhinol 2006 Mar-Apr;20(2):206-11

Zhang H, Shibuya K, Hemmi H, Nishino T, Prestwich GD, Total synthesis of geranylgeranylglyceryl phosphate enantiomers: substrates for characterization of 2,3-O-digeranylgeranylglyceryl phosphate synthase. Org Lett 2006 Mar 2;8(5):943-6

Qian L, Xu Y, Simper T, Jiang G, Aoki J, Umezu-Goto M, Arai H, Yu S, Mills GB, Tsukahara R, Makarova N, Fujiwara Y, Tigyi G, Prestwich GD, Phosphorothioate analogues of alkyl lysophosphatidic acid as LPA3 receptor-selective agonists. ChemMedChem 2006 Mar;1(3):376-83

Rose TM, Prestwich GD, Fluorogenic phospholipids as head group-selective reporters of phospholipase A activity. ACS Chem Biol 2006 Mar 17;1(2):83-91

Jiang G, Xu Y, Prestwich GD, Practical enantiospecific syntheses of lysobisphosphatidic acid and its analogues. J Org Chem 2006 Feb 3;71(3):934-9

Xu Y, Lee SA, Kutateladze TG, Sbrissa D, Shisheva A, Prestwich GD, Chemical synthesis and molecular recognition of phosphatase-resistant analogues of phosphatidylinositol-3-phosphate. J Am Chem Soc 2006 Jan 25;128(3):885-97

Prestwich GD, Shu XZ, Liu Y, Cai S, Walsh JF, Hughes CW, Ahmad S, Kirker KR, Yu B, Orlandi RR, Park AH, Thibeault SL, Duflo S, Smith ME, Injectable synthetic extracellular matrices for tissue engineering and repair. Adv Exp Med Biol 2006;585:125-33

Brunecky R, Lee S, Rzepecki PW, Overduin M, Prestwich GD, Kutateladze AG, Kutateladze T , Investigation of the Binding Geometry of a Peripheral Membrane Protein. Biochemistry 2005 Dec 13;44(49):16064-16071

Prestwich GD, Xu Y, Qian L, Gajewiak J, Jiang G, New metabolically stabilized analogues of lysophosphatidic acid: agonists, antagonists and enzyme inhibitors. Biochem Soc Trans 2005 Dec;33(Pt 6):1357-61

Ferguson CG, James RD, Bigman CS, Shepard DA, Abdiche Y, Katsamba PS, Myszka DG, Prestwich GD, Phosphoinositide-containing polymerized liposomes: stable membrane-mimetic vesicles for protein-lipid binding analysis. Bioconjug Chem 2005 Nov-Dec;16(6):1475-83

Cai S, Liu Y, Zheng Shu X, Prestwich GD, Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growth factor. Biomaterials 2005 Oct;26(30):6054-67

Prestwich GD, Visualization and perturbation of phosphoinositide and phospholipid signaling. Prostaglandins Other Lipid Mediat 2005 Sep;77(1-4):168-78

Jiang G, Xu Y, Falguières T, Gruenberg J, Prestwich GD, Concise synthesis of ether analogues of lysobisphosphatidic acid. Org Lett 2005 Sep 1;7(18):3837-40

Ghosh K, Shu XZ, Mou R, Lombardi J, Prestwich GD, Rafailovich MH, Clark R , Rheological Characterization of in Situ Cross-Linkable Hyaluronan Hydrogels. Biomacromolecules 2005 Sep 12;6(5):2857-2865

Hansen JK, Thibeault SL, Walsh JF, Shu XZ, Prestwich GD, In vivo engineering of the vocal fold extracellular matrix with injectable hyaluronic acid hydrogels: early effects on tissue repair and biomechanics in a rabbit model. Ann Otol Rhinol Laryngol 2005 Sep;114(9):662-70

Liu Y, Zheng Shu X, Prestwich GD, Biocompatibility and stability of disulfide-crosslinked hyaluronan films. Biomaterials 2005 Aug;26(23):4737-46

Dewald DB, Ozaki S, Malaviya S, Shope JC, Manabe K, Crosby L, Neilsen P, Johnston D, Harihar S, Prestwich GD, Cellular calcium mobilization in response to phosphoinositide delivery. Cell Calcium 2005 Aug;38(2):59-72

Xu Y, Aoki J, Shimizu K, Umezu-Goto M, Hama K, Takanezawa Y, Yu S, Mills GB, Arai H, Qian L, Prestwich GD, Structure-activity relationships of fluorinated lysophosphatidic acid analogues. J Med Chem 2005 May 5;48(9):3319-27

Liu Y, Li H, Shu XZ, Gray SD, Prestwich GD, Crosslinked hyaluronan hydrogels containing mitomycin C reduce postoperative abdominal adhesions. Fertil Steril 2005 Apr;83 Suppl 1:1275-83

Xu Y, Tanaka M, Arai H, Aoki J, Prestwich GD, Alkyl lysophosphatidic acid and fluoromethylene phosphonate analogs as metabolically-stabilized agonists for LPA receptors. Bioorg Med Chem Lett 2004 Nov 1;14(21):5323-8

Liu Y, Webb K, Kirker KR, Bernshaw NJ, Tresco PA, Gray SD, Prestwich GD, Composite articular cartilage engineered on a chondrocyte-seeded aliphatic polyurethane sponge. Tissue Eng 2004 Jul-Aug;10(7-8):1084-92

Gilbert ME, Kirker KR, Gray SD, Ward PD, Szakacs JG, Prestwich GD, Orlandi RR, Chondroitin sulfate hydrogel and wound healing in rabbit maxillary sinus mucosa. Laryngoscope 2004 Aug;114(8):1406-9

Kirker KR, Luo Y, Morris SE, Shelby J, Prestwich GD, Glycosaminoglycan hydrogels as supplemental wound dressings for donor sites. J Burn Care Rehabil 2004 May-Jun;25(3):276-86

Li H, Liu Y, Shu XZ, Gray SD, Prestwich GD, Synthesis and biological evaluation of a cross-linked hyaluronan-mitomycin C hydrogel. Biomacromolecules 2004 May-Jun;5(3):895-902

Prestwich GD, Phosphoinositide signaling; from affinity probes to pharmaceutical targets. Chem Biol 2004 May;11(5):619-37

Liu XH, Prestwich GD, Didehydrofarnesyl diphosphate: an intrinsically fluorescent inhibitor of protein farnesyltransferase. Bioorg Med Chem Lett 2004 May 3;14(9):2137-40

Prestwich GD, Visualizing signalling by phosphoinositide 3-kinase pathway lipids. Biochem Soc Trans 2004 Apr;32(Pt 2):336-7

Cai S, Dufner-Beattie JL, Prestwich GD, A selective protein sensor for heparin detection. Anal Biochem 2004 Mar 1;326(1):33-41

Xu Y, Fang Y, Chen J, Prestwich GD, Activation of mTOR signaling by novel fluoromethylene phosphonate analogues of phosphatidic acid. Bioorg Med Chem Lett 2004 Mar 22;14(6):1461-4

Liu XH, Suh DY, Call J, Prestwich GD, Antigenic prenylated peptide conjugates and polyclonal antibodies to detect protein prenylation. Bioconjug Chem 2004 Mar-Apr;15(2):270-7

Shu XZ, Ghosh K, Liu Y, Palumbo FS, Luo Y, Clark RA, Prestwich GD, Attachment and spreading of fibroblasts on an RGD peptide-modified injectable hyaluronan hydrogel. J Biomed Mater Res A 2004 Feb 1;68(2):365-75

Liu Y, Shu XZ, Gray SD, Prestwich GD, Disulfide-crosslinked hyaluronan-gelatin sponge: growth of fibrous tissue in vivo. J Biomed Mater Res A 2004 Jan 1;68(1):142-9

Zhang H, Liu XH, Zhang K, Chen CK, Frederick JM, Prestwich GD, Baehr W, Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein. J Biol Chem 2004 Jan 2;279(1):407-13

Qian L, Xu Y, Hasegawa Y, Aoki J, Mills GB, Prestwich GD, Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity. J Med Chem 2003 Dec 18;46(26):5575-8

Zheng Shu X, Liu Y, Palumbo FS, Luo Y, Prestwich GD, In situ crosslinkable hyaluronan hydrogels for tissue engineering. Biomaterials 2004 Mar-Apr;25(7-8):1339-48

Qian L, Xu Y, Arai H, Aoki J, McIntyre TM, Prestwich GD, Synthesis of migration-resistant hydroxyethoxy analogues of lysophosphatidic acid. Org Lett 2003 Nov 27;5(24):4685-8

Hinshaw JC, Suh DY, Garnier P, Buckner FS, Eastman RT, Matsuda SP, Joubert BM, Coppens I, Joiner KA, Merali S, Nash TE, Prestwich GD, Oxidosqualene cyclase inhibitors as antimicrobial agents. J Med Chem 2003 Sep 25;46(20):4240-3

Shu XZ, Liu Y, Palumbo F, Prestwich GD, Disulfide-crosslinked hyaluronan-gelatin hydrogel films: a covalent mimic of the extracellular matrix for in vitro cell growth. Biomaterials 2003 Sep;24(21):3825-34

Ward DM, Shiflett SL, Huynh D, Vaughn MB, Prestwich G, Kaplan , Use of expression constructs to dissect the functional domains of the CHS/beige protein: identification of multiple phenotypes. Traffic 2003 Jun;4(6):403-15

Xu Y, Qian L, Prestwich GD, Synthesis of alpha-fluorinated phosphonates from alpha-fluorovinylphosphonates: a new route to analogues of lysophosphatidic acid. Org Lett 2003 Jun 26;5(13):2267-70

Xu Y, Qian L, Prestwich GD, Synthesis of monofluorinated analogues of lysophosphatidic acid. J Org Chem 2003 Jun 27;68(13):5320-30

McIntyre TM, Pontsler AV, Silva AR, St Hilaire A, Xu Y, Hinshaw JC, Zimmerman GA, Hama K, Aoki J, Arai H, Prestwich GD, Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist. Proc Natl Acad Sci U S A 2003 Jan 7;100(1):131-6

Shu XZ, Liu Y, Luo Y, Roberts MC, Prestwich GD, Disulfide cross-linked hyaluronan hydrogels. Biomacromolecules 2002 Nov-Dec;3(6):1304-11

Xu Y, Prestwich GD, Synthesis of chiral (alpha,alpha-difluoroalkyl)phosphonate analogues of (lyso)phosphatidic acid via hydrolytic kinetic resolution. Org Lett 2002 Nov 14;4(23):4021-4

Xu Y, Prestwich GD, Concise synthesis of acyl migration-blocked 1,1-difluorinated analogues of lysophosphatidic acid. J Org Chem 2002 Oct 4;67(20):7158-61

Lazar J, Greenwood DR, Rasmussen LE, Prestwich GD, Molecular and functional characterization of an odorant binding protein of the Asian elephant, Elephas maximus: implications for the role of lipocalins in mammalian olfaction. Biochemistry 2002 Oct 1;41(39):11786-94

Kirker KR, Luo Y, Nielson JH, Shelby J, Prestwich GD, Glycosaminoglycan hydrogel films as bio-interactive dressings for wound healing. Biomaterials 2002 Sep;23(17):3661-71

Rzepecki PW, Prestwich GD, Synthesis of hybrid lipid probes: derivatives of phosphatidylethanolamine-extended phosphatidylinositol 4,5-bisphosphate (Pea-PIP(2)). J Org Chem 2002 Aug 9;67(16):5454-60

Vercruysse KP, Li H, Luo Y, Prestwich GD, Thermosensitive lanthanide complexes of hyaluronan. Biomacromolecules 2002 Jul-Aug;3(4):639-43

Prestwich GD, Matthew H, Hybrid, composite, and complex biomaterials. Ann N Y Acad Sci 2002 Jun;961:106-8

Chen R, Kang VH, Chen J, Shope JC, Torabinejad J, DeWald DB, Prestwich GD, A monoclonal antibody to visualize PtdIns(3,4,5)P(3) in cells. J Histochem Cytochem 2002 May;50(5):697-708

Luo Y, Bernshaw NJ, Lu ZR, Kopecek J, Prestwich GD, Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates. Pharm Res 2002 Apr;19(4):396-402

Rapoport N, Marin A, Luo Y, Prestwich GD, Muniruzzaman MD, Intracellular uptake and trafficking of Pluronic micelles in drug-sensitive and MDR cells: effect on the intracellular drug localization. J Pharm Sci 2002 Jan;91(1):157-70

Liu XH, Prestwich GD, Didehydrogeranylgeranyl (Delta Delta GG): a fluorescent probe for protein prenylation. J Am Chem Soc 2002 Jan 9;124(1):20-1

Prestwich GD, Chen R, Feng L, Ozaki S, Ferguson CG, Drees BE, Neklason DA, Mostert MJ, Porter-Gill PA, Kang VH, Shope JC, Neilsen PO, Dewald DB, In situ detection of phospholipid and phosphoinositide metabolism. Adv Enzyme Regul 2002;42:19-38

Luo Y, Prestwich GD, Hyaluronic acid-N-hydroxysuccinimide: a useful intermediate for bioconjugation. Bioconjug Chem 2001 Nov-Dec;12(6):1085-8

DeWald DB, Torabinejad J, Jones CA, Shope JC, Cangelosi AR, Thompson JE, Prestwich GD, Hama H, Rapid accumulation of phosphatidylinositol 4,5-bisphosphate and inositol 1,4,5-trisphosphate correlates with calcium mobilization in salt-stressed arabidopsis. Plant Physiol 2001 Jun;126(2):759-69

Davies SS, Pontsler AV, Marathe GK, Harrison KA, Murphy RC, Hinshaw JC, Prestwich GD, Hilaire AS, Prescott SM, Zimmerman GA, McIntyre TM, Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists. J Biol Chem 2001 May 11;276(19):16015-23

Feng L, Mejillano M, Yin HL, Chen J, Prestwich GD, Full-contact domain labeling: identification of a novel phosphoinositide binding site on gelsolin that requires the complete protein. Biochemistry 2001 Jan 30;40(4):904-13

Liu XH, Wang HK, Herron JN, Prestwich GD, Photopatterning of antibodies on biosensors. Bioconjug Chem 2000 Nov-Dec;11(6):755-61

Luo Y, Kirker KR, Prestwich GD, Cross-linked hyaluronic acid hydrogel films: new biomaterials for drug delivery. J Control Release 2000 Oct 3;69(1):169-84

Ozaki S, DeWald DB, Shope JC, Chen J, Prestwich GD, Intracellular delivery of phosphoinositides and inositol phosphates using polyamine carriers. Proc Natl Acad Sci U S A 2000 Oct 10;97(21):11286-91

Dang T, Prestwich GD, Site-directed mutagenesis of squalene-hopene cyclase: altered substrate specificity and product distribution. Chem Biol 2000 Aug;7(8):643-9

Mehrotra B, Myszka DG, Prestwich GD, Binding kinetics and ligand specificity for the interactions of the C2B domain of synaptogmin II with inositol polyphosphates and phosphoinositides. Biochemistry 2000 Aug 15;39(32):9679-86

Peng J, Chen PY, Marchase RB, Prestwich GD, Preparation and use of a photoactivatable glucose-6-phosphate analogue. Bioorg Med Chem Lett 2000 Mar 20;10(6):535-9

Luo Y, Ziebell MR, Prestwich GD, A hyaluronic acid-taxol antitumor bioconjugate targeted to cancer cells. Biomacromolecules 2000 Summer;1(2):208-18

Luo Y, Prestwich GD, Synthesis and selective cytotoxicity of a hyaluronic acid-antitumor bioconjugate. Bioconjug Chem 1999 Sep-Oct;10(5):755-63

Ganem B, Dong Y, Zheng YF, Prestwich GD, Amidrazone and Amidoxime Inhibitors of Squalene Hopene Cyclase. J Org Chem 1999 Jul 23;64(15):5441-5446

Dang T, Abe I, Zheng YF, Prestwich GD, The binding site for an inhibitor of squalene:hopene cyclase determined using photoaffinity labeling and molecular modeling. Chem Biol 1999 Jun;6(6):333-41

Vercruysse KP, Ziebell MR, Prestwich GD, Control of enzymatic degradation of hyaluronan by divalent cations. Carbohydr Res 1999 May 31;318(1-4):26-37

Abe I, Zheng YF, Prestwich GD, Mechanism-based inhibitors and other active-site targeted inhibitors of oxidosqualene cyclase and squalene cyclase. J Enzyme Inhib 1998 Sep;13(6):385-98

Prestwich GD, Marecak DM, Marecek JF, Vercruysse KP, Ziebell MR, Controlled chemical modification of hyaluronic acid: synthesis, applications, and biodegradation of hydrazide derivatives. J Control Release 1998 Apr 30;53(1-3):93-103

Chaudhary A, Gu QM, Thum O, Profit AA, Qi Y, Jeyakumar L, Fleischer S, Prestwich GD, Specific interaction of Golgi coatomer protein alpha-COP with phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998 Apr 3;273(14):8344-50

Zheng YF, Abe I, Prestwich GD, Inhibition kinetics and affinity labeling of bacterial squalene:hopene cyclase by thia-substituted analogues of 2, 3-oxidosqualene. Biochemistry 1998 Apr 28;37(17):5981-7

Abe I, Zheng YF, Prestwich GD, Photoaffinity labeling of oxidosqualene cyclase and squalene cyclase by a benzophenone-containing inhibitor. Biochemistry 1998 Apr 28;37(17):5779-84

Chen J, Prestwich GD, Asymmetric Synthesis of Water-Soluble, Nonhydrolyzable Phosphonate Analogue of Phosphatidylinositol 4,5-Bisphosphate. J Org Chem 1998 Feb 6;63(3):430-431

Vercruysse KP, Prestwich GD, Hyaluronate derivatives in drug delivery. Crit Rev Ther Drug Carrier Syst 1998;15(5):513-55

Vercruysse KP, Marecak DM, Marecek JF, Prestwich GD, Synthesis and in vitro degradation of new polyvalent hydrazide cross-linked hydrogels of hyaluronic acid. Bioconjug Chem 1997 Sep-Oct;8(5):686-94

Prestwich GD, Dormán G, Elliott JT, Marecak DM, Chaudhary A, Benzophenone photoprobes for phosphoinositides, peptides and drugs. Photochem Photobiol 1997 Feb;65(2):222-34

Mayer MP, Prestwich GD, Dolence JM, Bond PD, Wu HY, Poulter CD, Protein farnesyltransferase: production in Escherichia coli and immunoaffinity purification of the heterodimer from Saccharomyces cerevisiae. Gene 1993 Sep 30;132(1):41-7