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Natalya  Rapoport
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Phone: 801-231-2480
Office: MEB 2532

Natalya Rapoport

Selected Publications

Rapoport N, Drug-Loaded Perfluorocarbon Nanodroplets for Ultrasound-Mediated Drug Delivery. Adv Exp Med Biol 2016;880:221-41

Gupta R, Shea J, Scafe C, Shurlygina A, Rapoport N, Polymeric micelles and nanoemulsions as drug carriers: Therapeutic efficacy, toxicity, and drug resistance. J Control Release 2015 Aug 28;212:70-7

Rapoport N, Gupta R, Kim YS, O'Neill BE, Polymeric micelles and nanoemulsions as tumor-targeted drug carriers: Insight through intravital imaging. J Control Release 2015 May 28;206:153-60

Thakkar D, Gupta R, Monson K, Rapoport N, Effect of ultrasound on the permeability of vascular wall to nano-emulsion droplets. Ultrasound Med Biol 2013 Oct;39(10):1804-11

Rapoport N, Payne A, Dillon C, Shea J, Scaife C, Gupta R, Focused ultrasound-mediated drug delivery to pancreatic cancer in a mouse model. J Ther Ultrasound 2013 Jul 1;1:11

Rapoport N, Phase-shift, stimuli-responsive perfluorocarbon nanodroplets for drug delivery to cancer. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2012 Sep-Oct;4(5):492-510

Rapoport N, Ultrasound-mediated micellar drug delivery. Int J Hyperthermia 2012;28(4):374-85

Thakkar D, Gupta R, Mohan P, Monson K, Rapoport N, Overcoming Biological Barriers with Ultrasound. AIP Conf Proc 2012 Jan 1;1481:381-387

Rapoport N, Nam KH, Gupta R, Gao Z, Mohan P, Payne A, Todd N, Liu X, Kim T, Shea J, Scaife C, Parker DL, Jeong EK, Kennedy AM, Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions. J Control Release 2011 Jul 15;153(1):4-15

Shea JE, Nam KH, Rapoport N, Scaife CL, Genexol inhibits primary tumour growth and metastases in gemcitabine-resistant pancreatic ductal adenocarcinoma. HPB (Oxford) 2011 Mar;13(3):153-7

Mohan P, Rapoport N, Doxorubicin as a molecular nanotheranostic agent: effect of doxorubicin encapsulation in micelles or nanoemulsions on the ultrasound-mediated intracellular delivery and nuclear trafficking. Mol Pharm 2010 Dec 6;7(6):1959-73

Rapoport N, Christensen DA, Kennedy AM, Nam KH, Cavitation properties of block copolymer stabilized phase-shift nanoemulsions used as drug carriers. Ultrasound Med Biol 2010 Mar;36(3):419-29

Rapoport N, Kennedy AM, Shea JE, Scaife CL, Nam KH, Ultrasonic nanotherapy of pancreatic cancer: lessons from ultrasound imaging. Mol Pharm 2010 Feb 1;7(1):22-31

Rapoport NY, Nam KH, Gao Z, Kennedy A, Application of Ultrasound for Targeted Nanotherapy of Malignant Tumors. Acoust Phys 2009 Oct 1;55(4-5):594-601

Rapoport NY, Kennedy AM, Shea JE, Scaife CL, Nam KH, Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles. J Control Release 2009 Sep 15;138(3):268-76

Rapoport NY, Efros AL, Christensen DA, Kennedy AM, Nam KH, Microbubble Generation in Phase-Shift Nanoemulsions used as Anticancer Drug Carriers. Bubble Sci Eng Technol 2009;1(1-2):31-39

Gao Z, Kennedy AM, Christensen DA, Rapoport NY, Drug-loaded nano/microbubbles for combining ultrasonography and targeted chemotherapy. Ultrasonics 2008 Aug;48(4):260-70

Rapoport N, Nam KH, Gao Z, Cristensen DA, Kennedy AM, Acoustic properties of multifunctional nanomicrobubbles used in ultrasonography and ultrasound-mediated chemotherapy. J Acoust Soc Am 2008 May;123(5):3217

Rapoport N, Gao Z, Kennedy A, Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy. J Natl Cancer Inst 2007 Jul 18;99(14):1095-106

Gao Z, Fain HD, Rapoport N, Ultrasound-enhanced tumor targeting of polymeric micellar drug carriers. Mol Pharm 2004 Jul-Aug;1(4):317-30

Gao ZG, Fain HD, Rapoport N, Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultrasound. J Control Release 2005 Jan 20;102(1):203-22

Rapoport N, Combined cancer therapy by micellar-encapsulated drug and ultrasound. Int J Pharm 2004 Jun 11;277(1-2):155-62

Rapoport NY, Christensen DA, Fain HD, Barrows L, Gao Z, Ultrasound-triggered drug targeting of tumors in vitro and in vivo. Ultrasonics 2004 Apr;42(1-9):943-50

Rapoport N, Pitt WG, Sun H, Nelson JL, Drug delivery in polymeric micelles: from in vitro to in vivo. J Control Release 2003 Aug 28;91(1-2):85-95

Marin A, Sun H, Husseini GA, Pitt WG, Christensen DA, Rapoport NY, Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake. J Control Release 2002 Nov 7;84(1-2):39-47

Bohner M, Ring TA, Rapoport N, Caldwell KD, Fibrinogen adsorption by PS latex particles coated with various amounts of a PEO/PPO/PEO triblock copolymer. J Biomater Sci Polym Ed 2002;13(6):733-46

Rapoport N, Marin A, Luo Y, Prestwich GD, Muniruzzaman MD, Intracellular uptake and trafficking of Pluronic micelles in drug-sensitive and MDR cells: effect on the intracellular drug localization. J Pharm Sci 2002 Jan;91(1):157-70

Marin A, Muniruzzaman M, Rapoport N, Mechanism of the ultrasonic activation of micellar drug delivery. J Control Release 2001 Jul 10;75(1-2):69-81

Marin A, Muniruzzaman M, Rapoport N, Acoustic activation of drug delivery from polymeric micelles: effect of pulsed ultrasound. J Control Release 2001 Apr 28;71(3):239-49

Rapoport N, Marin AP, Timoshin AA, Effect of a polymeric surfactant on electron transport in HL-60 cells. Arch Biochem Biophys 2000 Dec 1;384(1):100-8

Husseini GA, Myrup GD, Pitt WG, Christensen DA, Rapoport NY, Factors affecting acoustically triggered release of drugs from polymeric micelles. J Control Release 2000 Oct 3;69(1):43-52

Rapoport NY, Herron JN, Pitt WG, Pitina L, Micellar delivery of doxorubicin and its paramagnetic analog, ruboxyl, to HL-60 cells: effect of micelle structure and ultrasound on the intracellular drug uptake. J Control Release 1999 Mar 29;58(2):153-62

Rapoport N, Smirnov AI, Pitt WG, Timoshin AA, Bioreduction of Tempone and spin-labeled gentamicin by gram-negative bacteria: kinetics and effect of ultrasound. Arch Biochem Biophys 1999 Feb 15;362(2):233-41

Rapoport N, Pitina L, Intracellular distribution and intracellular dynamics of a spin-labeled analogue of doxorubicin fluorescence and EPR spectroscopy. J Pharm Sci 1998 Mar;87(3):321-5

Rapoport N, Smirnov AI, Timoshin A, Pratt AM, Pitt WG, Factors affecting the permeability of Pseudomonas aeruginosa cell walls toward lipophilic compounds: effects of ultrasound and cell age. Arch Biochem Biophys 1997 Aug 1;344(1):114-24