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Bala  Ambati

Bala Ambati

Selected Publications

Mukhtar S, Ambati BK, Pediatric keratoconus: a review of the literature. Int Ophthalmol 2017 Aug 29;:

Zhang X, Bohner A, Bhuvanagiri S, Uehara H, Upadhyay AK, Emerson LL, Bondalapati S, Muddana SK, Fang D, Li M, Sandhu Z, Hussain A, Carroll LS, Tiem M, Archer B, Kompella U, Patil R, Ambati BK, Targeted Intraceptor Nanoparticle for Neovascular Macular Degeneration: Preclinical Dose Optimization and Toxicology Assessment. Mol Ther 2017 Jul 5;25(7):1606-1615

Bondalapati S, Ambati B, Intraocular foreign body removal: a novel technique using intraoperative imaging. Int Ophthalmol 2017 Jun;37(3):749-752

Uehara H, Muddana SK, Zhang X, Das SK, Bhuvanagiri S, Liu J, Wu Y, Choi S, Carroll LS, Archer B, Ambati BK, Targeted Delivery of FLT-Morpholino Using Cyclic RGD Peptide. Transl Vis Sci Technol 2017 May;6(3):9

Singh MK, Ambati BK, Crandall AS, New capsular tension segment with 2-point fixation for zonular weakness. J Cataract Refract Surg 2017 May;43(5):590-592

Ambati B, Re: Schwartz etáal.: Intracameral antibiotics and cataract surgery: endophthalmitis rates, cost, and stewardship (Ophthalmology. 2016;123:1411-1413). Ophthalmology 2017 Apr;124(4):e42-e43

Cho YK, Shin EY, Uehara H, Ambati BK, Effect of sorafenib in a murine high risk penetrating keratoplasty model. Int J Ophthalmol 2017;10(6):834-839

Lambert NG, ElShelmani H, Singh MK, Mansergh FC, Wride MA, Padilla M, Keegan D, Hogg RE, Ambati BK, Risk factors and biomarkers of age-related macular degeneration. Prog Retin Eye Res 2016 Sep;54:64-102

Ryskamp DA, Frye AM, Phuong TT, Yarishkin O, Jo AO, Xu Y, Lakk M, Iuso A, Redmon SN, Ambati B, Hageman G, Prestwich GD, Torrejon KY, Kri×aj D, TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye. Sci Rep 2016 Aug 11;6:30583

Zhou AX, Messenger WB, Sargent S, Ambati BK, Safety of undiluted intracameral moxifloxacin without postoperative topical antibiotics in cataract surgery. Int Ophthalmol 2016 Aug;36(4):493-8

Lambert NG, Zhang X, Rai RR, Uehara H, Choi S, Carroll LS, Das SK, Cahoon JM, Kirk BH, Bentley BM, Ambati BK, Subretinal AAV2.COMP-Ang1 suppresses choroidal neovascularization and vascular endothelial growth factor in a murine model of age-related macular degeneration. Exp Eye Res 2016 Apr;145:248-257

Rai RR, Messenger WB, Ambati BK, Hydrogel ocular sealant for wound closure during intrastromal corneal ring segment implantation. J Cataract Refract Surg 2016 Apr;42(4):515-9

Uehara H, Das SK, Cho YK, Archer B, Ambati BK, Comparison of the Anti-angiogenic and Anti-inflammatory Effects of Two Antibiotics: Clarithromycin Versus Moxifloxacin. Curr Eye Res 2016 Apr;41(4):474-84

Bondalapati S, Ambati B, Minimally Invasive Pterygium Surgery: Sutureless Excision with Amniotic Membrane and Hydrogel Sealant. Case Rep Ophthalmol 2016 Jan-Apr;7(1):79-84

Yasuma R, Cicatiello V, Mizutani T, Tudisco L, Kim Y, Tarallo V, Bogdanovich S, Hirano Y, Kerur N, Li S, Yasuma T, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ambati BK, Helmers SB, Lundberg IE, Viklicky O, Leusen JH, Verbeek JS, Gelfand BD, Ba, Intravenous immune globulin suppresses angiogenesis in mice and humans. Signal Transduct Target Ther 2016;1:

Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Tudisco L, Cicatiello V, Bastos-Carvalho A, Kerur N, Hirano Y, Baffi JZ, Tarallo V, Li S, Yasuma T, Arpitha P, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ruvo M, Sandomenico A, Nozaki M, Ijima R, Kan, Human IgG1 antibodies suppress angiogenesis in a target-independent manner. Signal Transduct Target Ther 2016;1:

Bell J, Harrison J, Mamalis N, Floyd A, Shakoor A, Ambati B, Concurrent Uveal and Vitreoretinal Lymphoma Masquerading as Anterior Uveitis. Ocul Immunol Inflamm 2016;24(1):120-3

Cahoon JM, Rai RR, Carroll LS, Uehara H, Zhang X, O'Neil CL, Medina RJ, Das SK, Muddana SK, Olson PR, Nielson S, Walker K, Flood MM, Messenger WB, Archer BJ, Barabas P, Krizaj D, Gibson CC, Li DY, Koh GY, Gao G, Stitt AW, Ambati BK, Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy. Diabetes 2015 Dec;64(12):4247-59

Pierce JL, Tanner K, Merrill RM, Miller KL, Ambati BK, Kendall KA, Roy N, Voice disorders in Sj÷gren's syndrome: Prevalence and related risk factors. Laryngoscope 2015 Jun;125(6):1385-92

Nie C, Zhang MN, Zhao HW, Olsen TD, Jackman K, Hu LN, Ma WP, Chen XF, Wang J, Zhang Y, Gao TS, Uehara H, Ambati BK, Luo L, Correlation of in vivo and in vitro methods in measuring choroidal vascularization volumes using a subretinal injection induced choroidal neovascularization model. Chin Med J (Engl) 2015 Jun 5;128(11):1516-22

Bosco A, Romero CO, Breen KT, Chagovetz AA, Steele MR, Ambati BK, Vetter ML, Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma. Dis Model Mech 2015 May;8(5):443-55

Gupta I, Cahoon J, Zhang X, Jones AD, Ahmed F, Uehara H, Messenger W, Ambati BK, Inávivo ZW800-microbead imaging of retinal and choroidal vascular leakage in mice. Exp Eye Res 2015 May;134:155-8

Bosco A, Romero CO, Ambati BK, Vetter ML, In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma. J Vis Exp 2015 May 11;(99):e52731

Zhang X, Das SK, Passi SF, Uehara H, Bohner A, Chen M, Tiem M, Archer B, Ambati BK, AAV2 delivery of Flt23k intraceptors inhibits murine choroidal neovascularization. Mol Ther 2015 Feb;23(2):226-34

Uehara H, Mamalis C, McFadden M, Taggart M, Stagg B, Passi S, Earle P, Chakravarthy U, Hogg RE, Ambati BK, The reduction of serum soluble Flt-1 in patients with neovascular age-related macular degeneration. Am J Ophthalmol 2015 Jan;159(1):92-100.e1-2

Hirano Y, Yasuma T, Mizutani T, Fowler BJ, Tarallo V, Yasuma R, Kim Y, Bastos-Carvalho A, Kerur N, Gelfand BD, Bogdanovich S, He S, Zhang X, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Nagai H, Haro I, N˙˝ez G, Ambati BK, Hinton DR, Ambati J, IL-18 is not therapeutic for neovascular age-related macular degeneration. Nat Med 2014 Dec;20(12):1372-5

Stagg BC, Uehara H, Lambert N, Rai R, Gupta I, Radmall B, Bates T, Ambati BK, Morpholino-Mediated Isoform Modulation of Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) Reduces Colon Cancer Xenograft Growth. Cancers (Basel) 2014 Nov 26;6(4):2330-42

Kim Y, Tarallo V, Kerur N, Yasuma T, Gelfand BD, Bastos-Carvalho A, Hirano Y, Yasuma R, Mizutani T, Fowler BJ, Li S, Kaneko H, Bogdanovich S, Ambati BK, Hinton DR, Hauswirth WW, Hakem R, Wright C, Ambati J, DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration. Proc Natl Acad Sci U S A 2014 Nov 11;111(45):16082-7

Chennamaneni SR, Bohner A, Bernhisel A, Ambati BK, Pharmacokinetics and efficacy of Bioerodible Dexamethasone implant in Concanavalin A-induced uveitic cataract rabbit model. Pharm Res 2014 Nov;31(11):3179-90

Taggart MG, Morshedi RG, Ambati BK, Trimanual Anterior Vitrectomy: A Novel Technique to Manage Vitreous Loss during Phacoemulsification. Case Rep Ophthalmol 2014 Sep;5(3):373-9

Ambati BK, Gender-based salary disparities: it pays to take a closer look. Acad Med 2014 Aug;89(8):1094

Cho YK, Archer B, Ambati BK, Dry eye predisposes to corneal neovascularization and lymphangiogenesis after corneal injury in a murine model. Cornea 2014 Jun;33(6):621-7

Owen LA, Morrison MA, Ahn J, Woo SJ, Sato H, Robinson R, Morgan DJ, Zacharaki F, Simeonova M, Uehara H, Chakravarthy U, Hogg RE, Ambati BK, Kotoula M, Baehr W, Haider NB, Silvestri G, Miller JW, Tsironi EE, Farrer LA, Kim IK, Park KH, DeAngelis MM, FLT1 genetic variation predisposes to neovascular AMD in ethnically diverse populations and alters systemic FLT1 expression. Invest Ophthalmol Vis Sci 2014 May 8;55(6):3543-54

Ambati B, Gender income disparities can be explained by alternative factors. JAMA Intern Med 2014 May;174(5):822-3

Das SK, Gupta I, Cho YK, Zhang X, Uehara H, Muddana SK, Bernhisel AA, Archer B, Ambati BK, Vimentin knockdown decreases corneal opacity. Invest Ophthalmol Vis Sci 2014 May 22;55(7):4030-40

Gupta I, Oakey Z, Ahmed F, Ambati BK, Spectacle Independence after Cataract Extraction in Post-Radial Keratotomy Patients Using Hybrid Monovision with ReSTOR(«) Multifocal and TECNIS(«) Monofocal Intraocular Lenses. Case Rep Ophthalmol 2014 May;5(2):157-61

Kumar S, Berriochoa Z, Ambati BK, Fu Y, Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epithelium. Invest Ophthalmol Vis Sci 2014 May 22;55(6):3842-50

Singh V, Jaini R, Torricelli AA, Santhiago MR, Singh N, Ambati BK, Wilson SE, TGF▀ and PDGF-B signaling blockade inhibits myofibroblast development from both bone marrow-derived and keratocyte-derived precursor cells inávivo. Exp Eye Res 2014 Apr;121:35-40

Ambati BK, Cahoon J, Rejuvenating clinician-scientist training. Invest Ophthalmol Vis Sci 2014 Mar 28;55(3):1853-5

Cahoon JM, Olson PR, Nielson S, Miya TR, Bankhead P, McGeown JG, Curtis TM, Ambati BK, Acridine orange leukocyte fluorography in mice. Exp Eye Res 2014 Mar;120:15-9

Kim HK, Choi JA, Uehara H, Zhang X, Ambati BK, Cho YK, Presurgical corticosteroid treatment improves corneal transplant survival in mice. Cornea 2013 Dec;32(12):1591-1598

Luo L, Uehara H, Zhang X, Das SK, Olsen T, Holt D, Simonis JM, Jackman K, Singh N, Miya TR, Huang W, Ahmed F, Bastos-Carvalho A, Le YZ, Mamalis C, Chiodo VA, Hauswirth WW, Baffi J, Lacal PM, Orecchia A, Ferrara N, Gao G, Young-Hee K, Fu Y, Owen L, Albuque, Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1. Elife 2013 Jun 18;2:e00324

Ambati B, A new target for simultaneous inhibition of hem- and lymphangiogenesis. Invest Ophthalmol Vis Sci 2013 Jun 26;54(6):4286

Singh N, Tiem M, Watkins R, Cho YK, Wang Y, Olsen T, Uehara H, Mamalis C, Luo L, Oakey Z, Ambati BK, Soluble vascular endothelial growth factor receptor 3 is essential for corneal alymphaticity. Blood 2013 May 16;121(20):4242-9

Gupta I, Oakey Z, Stagg BC, Ambati BK, Minus Piggyback Lens Overlaying ReSTOR(«) Multifocal Lens in High Myopia. Case Rep Ophthalmol 2013 May;4(2):57-60

Luo L, Zhang X, Hirano Y, Tyagi P, Barabßs P, Uehara H, Miya TR, Singh N, Archer B, Qazi Y, Jackman K, Das SK, Olsen T, Chennamaneni SR, Stagg BC, Ahmed F, Emerson L, Zygmunt K, Whitaker R, Mamalis C, Huang W, Gao G, Srinivas SP, Krizaj D, Baffi J, Ambati, Targeted intraceptor nanoparticle therapy reduces angiogenesis and fibrosis in primate and murine macular degeneration. ACS Nano 2013 Apr 23;7(4):3264-75

Chennamaneni SR, Mamalis C, Archer B, Oakey Z, Ambati BK, Development of a novel bioerodible dexamethasone implant for uveitis and postoperative cataract inflammation. J Control Release 2013 Apr 10;167(1):53-9

Uehara H, Cho Y, Simonis J, Cahoon J, Archer B, Luo L, Das SK, Singh N, Ambati J, Ambati BK, Dual suppression of hemangiogenesis and lymphangiogenesis by splice-shifting morpholinos targeting vascular endothelial growth factor receptor 2 (KDR). FASEB J 2013 Jan;27(1):76-85

Gooch N, Burr RM, Holt DJ, Gale B, Ambati B, Design and in vitro biocompatibility of a novel ocular drug delivery device. J Funct Biomater 2013 Jan 18;4(1):14-26

Cho YK, Uehara H, Young JR, Archer B, Ambati BK, Effect of glucocorticoid (triamcinolone acetonide) pretreatment in a murine penetrating keratoplasty and suture model. Cornea 2012 Dec;31(12):1468-75

Cho YK, Zhang X, Uehara H, Young JR, Archer B, Ambati B, Vascular Endothelial Growth Factor Receptor 1 morpholino increases graft survival in a murine penetrating keratoplasty model. Invest Ophthalmol Vis Sci 2012 Dec 19;53(13):8458-71

Cho YK, Uehara H, Young JR, Tyagi P, Kompella UB, Zhang X, Luo L, Singh N, Archer B, Ambati BK, Flt23k nanoparticles offer additive benefit in graft survival and anti-angiogenic effects when combined with triamcinolone. Invest Ophthalmol Vis Sci 2012 Apr 30;53(4):2328-36

Gooch N, Molokhia SA, Condie R, Burr RM, Archer B, Ambati BK, Wirostko B, Ocular drug delivery for glaucoma management. Pharmaceutics 2012 Mar 8;4(1):197-211

Qazi Y, Stagg B, Singh N, Singh S, Zhang X, Luo L, Simonis JM, Kompella UB, Ambati BK, Nanoparticle-mediated Delivery of shRNA.VEGF-A Plasmids Regresses Corneal Neovascularization. Invest Ophthalmol Vis Sci 2012 Mar 30;:

Cho YK, Uehara H, Young JR, Archer B, Zhang X, Ambati BK, Vascular endothelial growth factor receptor 1 morpholino decreases angiogenesis in a murine corneal suture model. Invest Ophthalmol Vis Sci 2012 Feb;53(2):685-92

Owen LA, Uehara H, Cahoon J, Huang W, Simonis J, Ambati BK, Morpholino-mediated increase in soluble Flt-1 expression results in decreased ocular and tumor neovascularization. PLoS One 2012;7(3):e33576

Holt DG, Young J, Stagg B, Ambati BK, Anterior chamber intraocular lens, sutured posterior chamber intraocular lens, or glued intraocular lens: where do we stand? Curr Opin Ophthalmol 2012 Jan;23(1):62-7

Wang H, Wittchen ES, Jiang Y, Ambati B, Grossniklaus HE, Hartnett ME, Upregulation of CCR3 by age-related stresses promotes choroidal endothelial cell migration via VEGF-dependent and -independent signaling. Invest Ophthalmol Vis Sci 2011 Oct 21;52(11):8271-7

Stagg BC, Ambati BK, Tarantula hairs as corneal foreign bodies. Case Rep Ophthalmol 2011 Sep;2(3):323-6

Jones A, Kumar S, Zhang N, Tong Z, Yang JH, Watt C, Anderson J, Amrita, Fillerup H, McCloskey M, Luo L, Yang Z, Ambati B, Marc R, Oka C, Zhang K, Fu Y, Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice. Proc Natl Acad Sci U S A 2011 Aug 30;108(35):14578-83

Zou J, Luo L, Shen Z, Chiodo VA, Ambati BK, Hauswirth WW, Yang J, Whirlin replacement restores the formation of the USH2 protein complex in whirlin knockout photoreceptors. Invest Ophthalmol Vis Sci 2011 Apr;52(5):2343-51

Maddula S, Davis DK, Maddula S, Burrow MK, Ambati BK, Horizons in therapy for corneal angiogenesis. Ophthalmology 2011 Mar;118(3):591-9

Jardine GJ, Wong GC, Elsnab JR, Gale BK, Ambati BK, Endocapsular carousel technique phacoemulsification. J Cataract Refract Surg 2011 Mar;37(3):433-7

Uehara H, Luo L, Simonis J, Singh N, Taylor EW, Ambati BK, Anti-SPARC oligopeptide inhibits laser-induced CNV in mice. Vision Res 2010 Mar 31;50(7):674-9

Molokhia SA, Sant H, Simonis J, Bishop CJ, Burr RM, Gale BK, Ambati BK, The capsule drug device: novel approach for drug delivery to the eye. Vision Res 2010 Mar 31;50(7):680-5

Qazi Y, Wong G, Monson B, Stringham J, Ambati BK, Corneal transparency: genesis, maintenance and dysfunction. Brain Res Bull 2010 Feb 15;81(2-3):198-210

Qazi Y, Maddula S, Ambati BK, Mediators of ocular angiogenesis. J Genet 2009 Dec;88(4):495-515