Personal Profile
Home → Directory → Faculty → Yan-Ting Shiu
Yan-Ting  Shiu
E-mail:

Yan-Ting Shiu

Research Associate Professor of Internal Medicine
Adjunct Assistant Professor, Bioengineering
1990-1994, B.S., Chemical Engineering, National Taiwan University
1994-1999, Ph.D., Chemical Engineering, Rice University
1999-2001, Postgraduate Researcher, Bioengineering, University of California-San Diego

Research

Hemodialysis vascular access, Vascular devices, Medical imaging and CFD analysis of blood flow, Vascular extracellular matrix and medical imaging of blood vessel walls, Vascular cell and molecular biology, Biomechanics, Biotransport phenomena


Current Research

Performance of a successful hemodialysis procedure requires a functional vascular access, which is a surgically-created blood conduit and the site on the patient’s body where blood is removed and returned during dialysis. Unfortunately, these conduits often fail and vascular access dysfunction is a major cause of morbidity and hospitalization in the hemodialysis population. No clinical therapies are currently available to significantly prevent or treat vascular access dysfunction. There are three main forms of hemodialysis vascular access: (1) the native arteriovenous fistula, (2) the synthetic arteriovenous graft, and (3) the cuffed double-lumen catheter. Each form has its own specific problems leading to failure. Dr. Shiu’s Research Laboratory is devoted to laboratory and clinical research related to understanding the pathophysiology of hemodialysis vascular access failure, and developing novel approaches to increase vascular access longevity and function.

Academic Bio:
Yan-Ting Shiu, Ph.D., is a Research Associate Professor of Medicine (Division of Nephrology) at the University of Utah. Dr. Shiu received her Ph.D. degree in Chemical Engineering from Rice University and received her post-doctoral research training in Bioengineering from the University of California at San Diego. Her research work draws from her engineering talents and strong knowledge in vascular biology and medicine. Her research laboratory is devoted to both clinical research and laboratory research (using experimental and computational techniques) related to hemodialysis vascular access and mechanobiology of vascular cells in health and in disease. Dr. Shiu has received research funding as a PI from the National Institutes of Health (R01), Veterans Affairs Western Institute for Biomedical Research, American Heart Association (National Program’s National Innovative Research Grant and Western States Affiliate’s Beginning Grant-in-Aid), National Kidney Foundation of Utah & Idaho, Whitaker Foundation (Biomedical Engineering Research Grant), and University of Utah Research Foundation and as a key senior co-investigator in several NIH R01, R21, R15, and K01 grants. She also has received research funding from the industry. Dr. Shiu’s teaching experiences include both classroom teaching and research mentoring in clinical and basic science studies. Dr. Shiu has a broad technical skill set and can effectively deliver materials in a broad range, from chemical engineering and biophysics to molecular cell biology. Her laboratory has been active in training undergraduate and graduate students and post-doctoral fellows. Since 2002, Dr. Shiu has served as a chair or member of over 40 masters and doctoral thesis research supervisory committees and as an advisor of over 15 senior theses and/or Undergraduate Research Opportunities Program Grants at the University of Utah. Dr. Shiu is an active and enthusiastic participant in the research community. Dr. Shiu’s professional external service has included reviewing journal manuscripts, grant proposals, book chapters for many journals, funding agencies and publishers, as well as organizing and moderating podium presentation sessions at regional and national scientific conferences. In particular, Dr. Shiu has reviewed manuscripts for over 20 journals ranging broadly from engineering and biophysics to biomedical sciences, and is a member of the American Heart Association Peer Review Study Group: Vascular Endothelial Biology 2 in 2016. Dr. Shiu is currently a member of the Biomedical Engineering Society Affiliations Committee (2015-2018), as well as a member of the Research Advisory Committee in the Department of Internal Medicine and the School of Medicine Admissions Committee at the University of Utah.

Please visit Dr. Shiu’s primary research page for more details:
http://medicine.utah.edu/internalmedicine/nephrology/labs/shiu_lab.php

Please visit Dr. Shiu’s biography page for her educational background:
https://faculty.utah.edu/u0324617-Yan-Ting_Shiu,_Ph.D./biography/index.hml


Selected Publications

Alpers CE, Imrey PB, Hudkins KL, Wietecha TA, Radeva M, Allon M, Cheung AK, Dember LM, Roy-Chaudhury P, Shiu YT, Terry CM, Farber A, Beck GJ, Feldman HI, Kusek JW, Himmelfarb J, Histopathology of Veins Obtained at Hemodialysis Arteriovenous Fistula Creation Surgery. J Am Soc Nephrol 2017 Jul 19;:

Shang F, Wang SC, Hsu CY, Miao Y, Martin M, Yin Y, Wu CC, Wang YT, Wu G, Chien S, Huang HD, Tarng DC, Shiu YT, Cheung AK, Huang PH, Chen Z, Shyy JY, MicroRNA-92a Mediates Endothelial Dysfunction in CKD. J Am Soc Nephrol 2017 Jul 10;:

Cheung AK, Imrey PB, Alpers CE, Robbin ML, Radeva M, Larive B, Shiu YT, Allon M, Dember LM, Greene T, Himmelfarb J, Roy-Chaudhury P, Terry CM, Vazquez MA, Kusek JW, Feldman HI, Intimal Hyperplasia, Stenosis, and Arteriovenous Fistula Maturation Failure in the Hemodialysis Fistula Maturation Study. J Am Soc Nephrol 2017 Jul 14;:

van Ballegooijen AJ, Zelnick L, Hoofnagle AN, Hamburg NM, Robinson-Cohen C, Roy-Chaudhury P, Cheung AK, Shiu YT, de Boer IH, Himmelfarb J, Beck G, Imrey PB, Kusek JW, Kestenbaum B, Association of Vitamin D Metabolites With Arterial Function in the Hemodialysis Fistula Maturation Study. Am J Kidney Dis 2017 Jun;69(6):805-814

Pike D, Shiu YT, Somarathna M, Guo L, Isayeva T, Totenhagen J, Lee T, High resolution hemodynamic profiling of murine arteriovenous fistula using magnetic resonance imaging and computational fluid dynamics. Theor Biol Med Model 2017 Mar 20;14(1):5

Allon M, Greene T, Dember LM, Vita JA, Cheung AK, Hamburg NM, Imrey PB, Kaufman JS, Robbin ML, Shiu YT, Terry CM, Umphrey HR, Feldman HI, Association between Preoperative Vascular Function and Postoperative Arteriovenous Fistula Development. J Am Soc Nephrol 2016 Dec;27(12):3788-3795

Machin DR, Leary ME, He Y, Shiu YT, Tanaka H, Donato AJ, Ultrasound Assessment of Flow-Mediated Dilation of the Brachial and Superficial Femoral Arteries in Rats. J Vis Exp 2016 Nov 3;(117):

Shiu YT, Litovsky SH, Cheung AK, Pike DB, Tey JC, Zhang Y, Young CJ, Robbin M, Hoyt K, Allon M, Preoperative Vascular Medial Fibrosis and Arteriovenous Fistula Development. Clin J Am Soc Nephrol 2016 Sep 7;11(9):1615-23

Robbin ML, Greene T, Cheung AK, Allon M, Berceli SA, Kaufman JS, Allen M, Imrey PB, Radeva MK, Shiu YT, Umphrey HR, Young CJ, Arteriovenous Fistula Development in the First 6 Weeks after Creation. Radiology 2016 May;279(2):620-9

Wilkins JR, Pike DB, Gibson CC, Li L, Shiu YT, The interplay of cyclic stretch and vascular endothelial growth factor in regulating the initial steps for angiogenesis. Biotechnol Prog 2015 Jan-Feb;31(1):248-57

Singhal AK, Symons JD, Boudina S, Jaishy B, Shiu YT, Role of Endothelial Cells in Myocardial Ischemia-Reperfusion Injury. Vasc Dis Prev 2010;7:1-14

Gibson CC, Zhu W, Davis CT, Bowman-Kirigin JA, Chan AC, Ling J, Walker AE, Goitre L, Delle Monache S, Retta SF, Shiu YT, Grossmann AH, Thomas KR, Donato AJ, Lesniewski LA, Whitehead KJ, Li DY, Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation. Circulation 2015 Jan 20;131(3):289-99

Kwon SH, Li L, He Y, Tey CS, Li H, Zhuplatov I, Kim SJ, Terry CM, Blumenthal DK, Shiu YT, Cheung AK, Prevention of Venous Neointimal Hyperplasia by a Multitarget Receptor Tyrosine Kinase Inhibitor. J Vasc Res 2015;52(4):244-256

Gomez AD, Zou H, Shiu YT, Hsu EW, Characterization of regional deformation and material properties of the intact explanted vein by microCT and computational analysis. Cardiovasc Eng Technol 2014 Dec;5(4):359-370

Wilkins JR, Pike DB, Gibson CC, Kubota A, Shiu YT, Differential effects of cyclic stretch on bFGF- and VEGF-induced sprouting angiogenesis. Biotechnol Prog 2014 Jul-Aug;30(4):879-88

Chapin LM, Edgar LT, Blankman E, Beckerle MC, Shiu YT, Mathematical modeling of the dynamic mechanical behavior of neighboring sarcomeres in actin stress fibers. Cell Mol Bioeng 2014 Mar 1;7(1):73-85

Fitts MK, Pike DB, Anderson K, Shiu YT, Hemodynamic Shear Stress and Endothelial Dysfunction in Hemodialysis Access. Open Urol Nephrol J 2014;7(Suppl 1 M5):33-44

Ives SJ, Andtbacka RH, Kwon SH, Shiu YT, Ruan T, Noyes RD, Zhang QJ, Symons JD, Richardson RS, Heat and a1-adrenergic responsiveness in human skeletal muscle feed arteries: the role of nitric oxide. J Appl Physiol (1985) 2012 Dec 1;113(11):1690-8

Chapin LM, Blankman E, Smith MA, Shiu YT, Beckerle MC, Lateral Communication between Stress Fiber Sarcomeres Facilitates a Local Remodeling Response. Biophys J 2012 Nov 21;103(10):2082-92

Brinton MR, Tagge CA, Stewart RJ, Cheung AK, Shiu YT, Christensen DA, Thermal sensitivity of endothelial cells on synthetic vascular graft material. Int J Hyperthermia 2012;28(2):163-74

Brinton MR, Stewart RJ, Cheung AK, Christensen DA, Shiu YT, Modelling ultrasound-induced mild hyperthermia of hyperplasia in vascular grafts. Theor Biol Med Model 2011 Nov 3;8:42

Wilson BD, Gibson CC, Sorensen LK, Guilhermier MY, Clinger M, Kelley LL, Shiu YT, Li DY, Novel approach for endothelializing vascular devices: understanding and exploiting elastin-endothelial interactions. Ann Biomed Eng 2011 Jan;39(1):337-46

Li L, Terry CM, Shiu YT, Cheung AK, Neointimal hyperplasia associated with synthetic hemodialysis grafts. Kidney Int 2008 Nov;74(10):1247-61

Joung IS, Iwamoto MN, Shiu YT, Quam CT, Cyclic strain modulates tubulogenesis of endothelial cells in a 3D tissue culture model. Microvasc Res 2006 Jan;71(1):1-11

Chien S, Li S, Shiu YT, Li Y , Molecular basis of mechanical modulation of endothelial cell migration. Front Biosci 2005 May 1;10:1985-2000

Miao H, Hu YL, Shiu YT, Yuan S, Zhao Y, Kaunas R, Wang X, Jin G, Usami S, and Chien S., Effects of flow patterns on the localization and expression of VE-cadherin at vascular endothelial cell junctions: in-vivo and in-vitro investigations. Journal of Vascular Research 2005;42:77-89

Shiu YT, Weiss JA, Hoying JB, Iwamoto MN, Joung IS, Quam CT, The role of mechanical stresses in angiogenesis. Crit Rev Biomed Eng 2005;33(5):431-510

Shiu YT, Li S, Marganski WA, Usami S, Schwartz MA, Wang YL, Dembo M, Chien S., Rho mediates the shear-enhancement of endothelial cell migration and traction force generation Biophysical Journal 2004 Apr;86:2558-2565

Shiu YT, McIntire LV, In vitro studies of erythrocyte-vascular endothelium interactions. Ann Biomed Eng 2003 Dec;31(11):1299-313

Shiu YT, Li S, Yuan S, Wang Y, Nguyen P, Chien S., Shear stress-induced c-fos activation is mediated by Rho in a calcium-dependent manner Biochem Biophys Res Commun. 2003 Apr;4:548-555

Shiu YT, McIntire LV, and Udden MM., Sickle erythrocytes increase prostacyclin and endothelin-1 production by cultured human vein endothelial cells under flow conditions European Journal of Haematology 2002 Mar;68(3):163-169

Li S, Bhatia S, Hu YL, Shiu YT, Li YS, Usami S, Chien S., Effects of morphological patterning on endothelial cell migration Biorheology 2001;38:101-108

Shiu YT, Udden MM, and McIntire LV, Perfusion with sickle erythrocytes upregulates ICAM-1and VCAM-1 gene expression in cultured human endothelial cells Blood 2000;95:3232-3241