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R. Tyler McCabe

Phone: 801-550-9956
Office: 801-587-0506

R. Tyler McCabe

Selected Publications

Johnson TJ, Clark MR, Albright TH, Nebeker JS, Tuitupou AL, Clark JT, Fabian J, McCabe RT, Chandra N, Doncel GF, Friend DR, Kiser PF, A 90-day tenofovir reservoir intravaginal ring for mucosal HIV prophylaxis. Antimicrob Agents Chemother 2012 Dec;56(12):6272-83

Clark MR, Johnson TJ, McCabe RT, Clark JT, Tuitupou A, Elgendy H, Friend DR, Kiser PF, A hot-melt extruded intravaginal ring for the sustained delivery of the antiretroviral microbicide UC781. J Pharm Sci 2012 Feb;101(2):576-87

Nuovo GJ, Bartholomew D, Jung WW, Han IK, Um T, Grabarz DF, Lee DJ, McCabe RT, Correlation of Pap smear, cervical biopsy, and clinical follow-up with an HPV typing microarray system. Diagn Mol Pathol 2008 Jun;17(2):107-11

Allen JW, Hofer K, McCumber D, Wagstaff JD, Layer RT, McCabe RT, Yaksh TL, An assessment of the antinociceptive efficacy of intrathecal and epidural contulakin-G in rats and dogs. Anesth Analg 2007 Jun;104(6):1505-13, table of contents

Malmberg AB, Gilbert H, McCabe RT, Basbaum AI, Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T. Pain 2003 Jan;101(1-2):109-16

Williams AJ, Ling G, McCabe RT, Tortella FC, Intrathecal CGX-1007 is neuroprotective in a rat model of focal cerebral ischemia. Neuroreport 2002 May 7;13(6):821-4

Donevan SD, McCabe RT, Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors. Mol Pharmacol 2000 Sep;58(3):614-23

Adams AC, Layer RT, McCabe RT, Keefe KA, Effects of conantokins on L-3,4-dihydroxyphenylalanine-induced behavior and immediate early gene expression. Eur J Pharmacol 2000 Sep 22;404(3):303-13

Lian H, Steiner SS, Sofia RD, Woodhead JH, Wolf HH, White HS, Shen GS, Rhodes CA, McCabe RT, A self-complementary, self-assembling microsphere system: application for intravenous delivery of the antiepileptic and neuroprotectant compound felbamate. J Pharm Sci 2000 Jul;89(7):867-75

Williams AJ, Dave JR, Phillips JB, Lin Y, McCabe RT, Tortella FC, Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies. J Pharmacol Exp Ther 2000 Jul;294(1):378-86

Shen GS, Layer RT, McCabe RT, Conopeptides: From deadly venoms to novel therapeutics. Drug Discov Today 2000 Mar;5(3):98-106

Bush L, McCabe T, Hanson GR, Selective antagonism of nigral neuropeptide responses to methamphetamine by conantokin G, a naturally occurring conopeptide. Eur J Pharmacol 2000 Jan 3;387(1):55-8

White HS, McCabe RT, Armstrong H, Donevan SD, Cruz LJ, Abogadie FC, Torres J, Rivier JE, Paarmann I, Hollmann M, Olivera BM, In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. J Pharmacol Exp Ther 2000 Jan;292(1):425-32

Rogers JP, Luginbühl P, Shen GS, McCabe RT, Stevens RC, Wemmer DE, NMR solution structure of alpha-conotoxin ImI and comparison to other conotoxins specific for neuronal nicotinic acetylcholine receptors. Biochemistry 1999 Mar 30;38(13):3874-82

McCabe RT, Sofia RD, Layer RT, Leiner KA, Faull RL, Narang N, Wamsley JK, Felbamate increases [3H]glycine binding in rat brain and sections of human postmortem brain. J Pharmacol Exp Ther 1998 Aug;286(2):991-9

Wamsley JK, Sofia RD, Faull RL, Narang N, Ary T, McCabe RT, Interaction of felbamate with [3H]DCKA-labeled strychnine-insensitive glycine receptors in human postmortem brain. Exp Neurol 1994 Oct;129(2):244-50

Wamsley JK, Sofia RD, Faull RL, Narang N, Ary T, Gan XD, McCabe RT, Felbamate: interaction with glycine receptors in human cerebral cortex. Proc West Pharmacol Soc 1994;37:81-3

Wamsley JK, Sofia RD, Faull RL, Ary T, Narang N, McCabe RT, Use of [3H]5,7 dichlorokynurenic acid to identify strychnine-insensitive glycine receptors in human postmortem brain. Brain Res Bull 1994;35(3):205-9

McCabe RT, Wasterlain CG, Kucharczyk N, Sofia RD, Vogel JR, Evidence for anticonvulsant and neuroprotectant action of felbamate mediated by strychnine-insensitive glycine receptors. J Pharmacol Exp Ther 1993 Mar;264(3):1248-52

McCabe RT, Skolnick P, Jacobson KA, 2-[2-[4-[2-[2-[ 1,3-Dihydro- 1,1-bis (4-hydroxyphenyl)-3-oxo-5-isobenzofuranthioureidyl]ethylaminocarbonyl]ethyl]phenyl] ethylamino]-5'-N-ethylcarboxamidoadenosine (FITC-APEC): A Fluorescent Ligand For A2a-Adenosine Receptors. J Fluoresc 1992 Dec;2(4):217-223

Chang YJ, McCabe RT, Rennert H, Budarf ML, Sayegh R, Emanuel BS, Skolnick P, Strauss JF 3rd, The human "peripheral-type" benzodiazepine receptor: regional mapping of the gene and characterization of the receptor expressed from cDNA. DNA Cell Biol 1992 Jul-Aug;11(6):471-80

McCabe RT, Newman AH, Skolnick P, AHN 683: a fluorescent ligand for peripheral-type benzodiazepine receptors. J Pharmacol Exp Ther 1992 Aug;262(2):734-40

Von Lubitz DK, Lin RC, McKenzie RJ, Devlin TM, McCabe RT, Skolnick P, A novel treatment of global cerebral ischaemia with a glycine partial agonist. Eur J Pharmacol 1992 Aug 14;219(1):153-8

McCabe RT, Mahan DR, Smith RB, Wamsley JK, Characterization of [3H]alprazolam binding to central benzodiazepine receptors. Pharmacol Biochem Behav 1990 Oct;37(2):365-70

McCabe RT, de Costa BR, Miller RL, Havunjian RH, Rice KC, Skolnick P, Characterization of benzodiazepine receptors with fluorescent ligands. FASEB J 1990 Aug;4(11):2934-40

Olsen RW, McCabe RT, Wamsley JK, GABAA receptor subtypes: autoradiographic comparison of GABA, benzodiazepine, and convulsant binding sites in the rat central nervous system. J Chem Neuroanat 1990 Jan-Feb;3(1):59-76

Newman AH, McCabe RT, Schoenheimer JA, Skolnick P, [3H]AHN 070: a high affinity irreversible radioligand for characterization of peripheral benzodiazepine receptors. NIDA Res Monogr 1990;105:435-6

McCabe RT, Schoenheimer JA, Skolnick P, Newman AH, Rice KC, Reig JA, Klein DC, [3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland. FEBS Lett 1989 Feb 27;244(2):263-7

Newman AH, Arora P, McRae B, McCabe RT, Skolnick P, Fluorescent probes for peripheral-type benzodiazepine receptor visualization and localization. NIDA Res Monogr 1989;95:520-1

Newman AH, McCabe RT, Schoenheimer JA, Skolnick P, Rice KC, Reig JA, Klein DC, [3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland. NIDA Res Monogr 1989;95:285-6

Yezuita JP, McCabe RT, Barnett A, Iorio LC, Wamsley JK, Use of the selective benzodiazepine-1 (BZ-1) ligand [3H]2-oxo-quazepam (SCH 15-725) to localize BZ-1 receptors in the rat brain. Neurosci Lett 1988 May 16;88(1):86-92

McCabe RT, Olsen RW, Yezuita JP, Wamsley JK, Osmotic shock: a method to eliminate endogenous gamma-aminobutyric acid and account for the influence on benzodiazepine binding affinity in autoradiographic studies. J Pharmacol Exp Ther 1988 Apr;245(1):342-9

Byerley WF, McConnell EJ, McCabe RT, Dawson TM, Grosser BI, Wamsley JK, Decreased beta-adrenergic receptors in rat brain after chronic administration of the selective serotonin uptake inhibitor fluoxetine. Psychopharmacology (Berl) 1988;94(1):141-3

McCabe RT, Wamsley JK, Yezuita JP, Olsen RW, A novel GABAA antagonist [3H]SR 95531: microscopic analysis of binding in the rat brain and allosteric modulation by several benzodiazepine and barbiturate receptor ligands. Synapse 1988;2(2):163-73

McCabe RT, Gibb JW, Wamsley JK, Hanson GR, Autoradiographic analysis of muscarinic cholinergic and serotonergic receptor alterations following methamphetamine treatment. Brain Res Bull 1987 Nov;19(5):551-7

McCabe RT, Hanson GR, Dawson TM, Wamsley JK, Gibb JW, Methamphetamine-induced reduction in D1 and D2 dopamine receptors as evidenced by autoradiography: comparison with tyrosine hydroxylase activity. Neuroscience 1987 Oct;23(1):253-61

Dawson TM, McCabe RT, Stensaas SS, Wamsley JK, Autoradiographic evidence of [3H]SCH 23390 binding sites in human prefrontal cortex (Brodmann's area 9). J Neurochem 1987 Sep;49(3):789-96

Byerley WF, McConnell EJ, McCabe RT, Dawson TM, Grosser BI, Wamsley JK, Chronic administration of sertraline, a selective serotonin uptake inhibitor, decreased the density of beta-adrenergic receptors in rat frontoparietal cortex. Brain Res 1987 Sep 22;421(1-2):377-81

Wamsley JK, Byerley WF, McCabe RT, McConnell EJ, Dawson TM, Grosser BI, Receptor alterations associated with serotonergic agents: an autoradiographic analysis. J Clin Psychiatry 1987 Mar;48 Suppl:19-25

McCabe RT, Wamsley JK, Autoradiographic localization of subcomponents of the macromolecular GABA receptor complex. Life Sci 1986 Nov 24;39(21):1937-45

Dawson TM, Gehlert DR, McCabe RT, Barnett A, Wamsley JK, D-1 dopamine receptors in the rat brain: a quantitative autoradiographic analysis. J Neurosci 1986 Aug;6(8):2352-65

Lee RJ, McCabe RT, Wamsley JK, Olsen RW, Lomax P, Opioid receptor alterations in a genetic model of generalized epilepsy. Brain Res 1986 Aug 13;380(1):76-82

Olsen RW, Wamsley JK, McCabe RT, Lee RJ, Lomax P, Benzodiazepine/gamma-aminobutyric acid receptor deficit in the midbrain of the seizure-susceptible gerbil. Proc Natl Acad Sci U S A 1985 Oct;82(19):6701-5

Grabowsky KL, McCabe RT, Wamsley JK, Localization of [3H]-imipramine binding sites in rat brain by light microscopic autoradiography. Life Sci 1983 May 16;32(20):2355-61