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Kenneth W. Spitzer

Phone: 801-581-8183
Office: 156 CVRTI

Kenneth W. Spitzer

Professor of Physiology
Adjunct Professor, Bioengineering

Selected Publications

Warren M, Sciuto KJ, Taylor TG, Garg V, Torres NS, Shibayama J, Spitzer KW, Zaitsev AV, Blockade of CaMKII depresses conduction preferentially in the right ventricular outflow tract and promotes ischemic ventricular fibrillation in the rabbit heart. Am J Physiol Heart Circ Physiol 2017 Apr 1;312(4):H752-H767

Lopez-Izquierdo A, Warren M, Riedel M, Cho S, Lai S, Lux RL, Spitzer KW, Benjamin IJ, Tristani-Firouzi M, Jou CJ, A near-infrared fluorescent voltage-sensitive dye allows for moderate-throughput electrophysiological analyses of human induced pluripotent stem cell-derived cardiomyocytes. Am J Physiol Heart Circ Physiol 2014 Nov 1;307(9):H1370-7

Riedel M, Jou CJ, Lai S, Lux RL, Moreno AP, Spitzer KW, Christians E, Tristani-Firouzi M, Benjamin IJ, Functional and pharmacological analysis of cardiomyocytes differentiated from human peripheral blood mononuclear-derived pluripotent stem cells. Stem Cell Reports 2014 Jul 8;3(1):131-41

Torres NS, Sachse FB, Izu LT, Goldhaber JI, Spitzer KW, Bridge JH, A modified local control model for Ca2+ transients in cardiomyocytes: junctional flux is accompanied by release from adjacent non-junctional RyRs. J Mol Cell Cardiol 2014 Mar;68:1-11

Zhang XQ, Tang R, Li L, Szucsik A, Javan H, Saegusa N, Spitzer KW, Selzman CH, Cardiomyocyte-specific p65 NF-?B deletion protects the injured heart by preservation of calcium handling. Am J Physiol Heart Circ Physiol 2013 Oct 1;305(7):H1089-97

Saegusa N, Garg V, Spitzer KW, Modulation of ventricular transient outward K? current by acidosis and its effects on excitation-contraction coupling. Am J Physiol Heart Circ Physiol 2013 Jun 15;304(12):H1680-96

Venable PW, Taylor TG, Sciuto KJ, Zhao J, Shibayama J, Warren M, Spitzer KW, Zaitsev AV, Detection of mitochondrial depolarization/recovery during ischaemia--reperfusion using spectral properties of confocally recorded TMRM fluorescence. J Physiol 2013 Jun 1;591(11):2781-94

Shibayama J, Taylor TG, Venable PW, Rhodes NL, Gil RB, Warren M, Wende AR, Abel ED, Cox J, Spitzer KW, Zaitsev AV, Metabolic determinants of electrical failure in ex-vivo canine model of cardiac arrest: evidence for the protective role of inorganic pyrophosphate. PLoS One 2013;8(3):e57821

McNary TG, Spitzer KW, Holloway H, Bridge JH, Kohl P, Sachse FB, Mechanical modulation of the transverse tubular system of ventricular cardiomyocytes. Prog Biophys Mol Biol 2012 Oct-Nov;110(2-3):218-25

Ajiro Y, Saegusa N, Giles WR, Stafforini DM, Spitzer KW, Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes. Am J Physiol Heart Circ Physiol 2011 Dec;301(6):H2395-401

Saegusa N, Moorhouse E, Vaughan-Jones RD, Spitzer KW, Influence of pH on CaČ? current and its control of electrical and CaČ? signaling in ventricular myocytes. J Gen Physiol 2011 Nov;138(5):537-59

Warren M, Spitzer KW, Steadman BW, Rees TD, Venable P, Taylor T, Shibayama J, Yan P, Wuskell JP, Loew LM, Zaitsev AV, High-precision recording of the action potential in isolated cardiomyocytes using the near-infrared fluorescent dye di-4-ANBDQBS. Am J Physiol Heart Circ Physiol 2010 Oct;299(4):H1271-81

Jou CJ, Spitzer KW, Tristani-Firouzi M, Blebbistatin effectively uncouples the excitation-contraction process in zebrafish embryonic heart. Cell Physiol Biochem 2010;25(4-5):419-24

Barry WH, Zhang XQ, Halkos ME, Vinten-Johansen J, Saegusa N, Spitzer KW, Matsuoka N, Sheets M, Rao NV, Kennedy TP, Nonanticoagulant heparin reduces myocyte Na+ and Ca2+ loading during simulated ischemia and decreases reperfusion injury. Am J Physiol Heart Circ Physiol 2010 Jan;298(1):H102-11

Spitzer KW, Pollard AE, Yang L, Zaniboni M, Cordeiro JM, Huelsing DJ, Cell-to-cell electrical interactions during early and late repolarization. J Cardiovasc Electrophysiol 2006 May;17 Suppl 1:S8-S14

Seguchi H, Ritter M, Shizukuishi M, Ishida H, Chokoh G, Nakazawa H, Spitzer KW, Barry WH, Propagation of Ca2+ release in cardiac myocytes: role of mitochondria. Cell Calcium 2005 Jul;38(1):1-9

Yamamoto T, Swietach P, Rossini A, Loh SH, Vaughan-Jones RD, Spitzer KW, Functional diversity of electrogenic Na+-HCO3- cotransport in ventricular myocytes from rat, rabbit and guinea pig. J Physiol 2005 Jan 15;562(Pt 2):455-75

Su Z, Li F, Spitzer KW, Yao A, Ritter M, Barry WH, Comparison of sarcoplasmic reticulum Ca2+-ATPase function in human, dog, rabbit, and mouse ventricular myocytes. J Mol Cell Cardiol 2003 Jul;35(7):761-7

Ritter M, Sui Z, Philipson KD, Li F, Spitzer KW, Ishida H, Barry WH, Ca2+ sparks induced by Na/Ca exchange. Cell Calcium 2003 Jul;34(1):11-7

Spitzer KW, Skolnick RL, Peercy BE, Keener JP, Vaughan-Jones RD, Facilitation of intracellular H(+) ion mobility by CO(2)/HCO(3)(-) in rabbit ventricular myocytes is regulated by carbonic anhydrase. J Physiol 2002 May 15;541(Pt 1):159-67

Cordeiro JM, Bridge JH, Spitzer KW, Early and delayed afterdepolarizations in rabbit heart Purkinje cells viewed by confocal microscopy. Cell Calcium 2001 May;29(5):289-97

Cordeiro JM, Spitzer KW, Giles WR, Ershler PE, Cannell MB, Bridge JH, Location of the initiation site of calcium transients and sparks in rabbit heart Purkinje cells. J Physiol 2001 Mar 1;531(Pt 2):301-14

Su Z, Sugishita K, Ritter M, Li F, Spitzer KW, Barry WH, The sodium pump modulates the influence of I(Na) on [Ca2+]i transients in mouse ventricular myocytes. Biophys J 2001 Mar;80(3):1230-7

Spitzer KW, Ershler PR, Skolnick RL, Vaughan-Jones RD, Generation of intracellular pH gradients in single cardiac myocytes with a microperfusion system. Am J Physiol Heart Circ Physiol 2000 Apr;278(4):H1371-82

Ritter M, Su Z, Spitzer KW, Ishida H, Barry WH, Caffeine-induced Ca(2+) sparks in mouse ventricular myocytes. Am J Physiol Heart Circ Physiol 2000 Feb;278(2):H666-9

Su Z, Bridge JH, Philipson KD, Spitzer KW, Barry WH, Quantitation of Na/Ca exchanger function in single ventricular myocytes. J Mol Cell Cardiol 1999 May;31(5):1125-35

Zaniboni M, Yao A, Barry WH, Musso E, Spitzer KW, Complications associated with rapid caffeine application to cardiac myocytes that are not voltage clamped. J Mol Cell Cardiol 1998 Nov;30(11):2229-35

Skolnick RL, Litwin SE, Barry WH, Spitzer KW, Effect of ANG II on pHi, [Ca2+]i, and contraction in rabbit ventricular myocytes from infarcted hearts. Am J Physiol 1998 Nov;275(5 Pt 2):H1788-97

Yao A, Su Z, Nonaka A, Zubair I, Spitzer KW, Bridge JH, Muelheims G, Ross J Jr, Barry WH, Abnormal myocyte Ca2+ homeostasis in rabbits with pacing-induced heart failure. Am J Physiol 1998 Oct;275(4 Pt 2):H1441-8

Sato N, Habuchi Y, Tanaka H, Kawamura Y, Kikuchi K, Spitzer KW, Giles WR, [Electrophysiological heterogeneity of rabbit atrioventricular node cells: possible relationship to fast and slow pathways]. J Cardiol 1998 Jun;31(6):373-80

Yao A, Matsui H, Spitzer KW, Bridge JH, Barry WH, Sarcoplasmic reticulum and Na+/Ca2+ exchanger function during early and late relaxation in ventricular myocytes. Am J Physiol 1997 Dec;273(6 Pt 2):H2765-73

Yao A, Spitzer KW, Ito N, Zaniboni M, Lorell BH, Barry WH, The restriction of diffusion of cations at the external surface of cardiac myocytes varies between species. Cell Calcium 1997 Dec;22(6):431-8

Spitzer KW, Sato N, Tanaka H, Firek L, Zaniboni M, Giles WR, Electrotonic modulation of electrical activity in rabbit atrioventricular node myocytes. Am J Physiol 1997 Aug;273(2 Pt 2):H767-76

Litwin S, Kohmoto O, Levi AJ, Spitzer KW, Bridge JH, Evidence that reverse Na-Ca exchange can trigger SR calcium release. Ann N Y Acad Sci 1996 Apr 15;779:451-63

Burgess MJ, Pollard AE, Spitzer KW, Yang L, Effects of premature beats on repolarization of postextrasystolic beats. Circulation 1995 Oct 1;92(7):1969-80

Matsui H, Barry WH, Livsey C, Spitzer KW, Angiotensin II stimulates sodium-hydrogen exchange in adult rabbit ventricular myocytes. Cardiovasc Res 1995 Feb;29(2):215-21

Barry WH, Matsui H, Bridge JH, Spitzer KW, Excitation-contraction coupling in ventricular myocytes: effects of angiotensin II. Adv Exp Med Biol 1995;382:31-9

Xu P, Spitzer KW, Na-independent Cl(-)-HCO3- exchange mediates recovery of pHi from alkalosis in guinea pig ventricular myocytes. Am J Physiol 1994 Jul;267(1 Pt 2):H85-91

Zubair I, Pollard AE, Spitzer KW, Burgess MJ, Effects of activation sequence on the spatial distribution of repolarization properties. J Electrocardiol 1994 Apr;27(2):115-27

Levi AJ, Spitzer KW, Kohmoto O, Bridge JH, Depolarization-induced Ca entry via Na-Ca exchange triggers SR release in guinea pig cardiac myocytes. Am J Physiol 1994 Apr;266(4 Pt 2):H1422-33

Pollard AE, Burgess MJ, Spitzer KW, Computer simulations of three-dimensional propagation in ventricular myocardium. Effects of intramural fiber rotation and inhomogeneous conductivity on epicardial activation. Circ Res 1993 Apr;72(4):744-56

Chin TK, Spitzer KW, Philipson KD, Bridge JH, The effect of exchanger inhibitory peptide (XIP) on sodium-calcium exchange current in guinea pig ventricular cells. Circ Res 1993 Mar;72(3):497-503

Spitzer KW, Bridge JH, Relationship between intracellular pH and tension development in resting ventricular muscle and myocytes. Am J Physiol 1992 Feb;262(2 Pt 1):C316-27

Spitzer KW, Steinhaus BM, Hirai M, Haws CW, Burgess MJ, Modulation of collision-induced changes in canine heart repolarization by cycle length. J Electrocardiol 1991 Jan;24(1):43-52

Bridge JH, Smolley J, Spitzer KW, Chin TK, Voltage dependence of sodium-calcium exchange and the control of calcium extrusion in the heart. Ann N Y Acad Sci 1991;639:34-47

Bridge JH, Smolley JR, Spitzer KW, The relationship between charge movements associated with ICa and INa-Ca in cardiac myocytes. Science 1990 Apr 20;248(4953):376-8

Kohmoto O, Spitzer KW, Movsesian MA, Barry WH, Effects of intracellular acidosis on [Ca2+]i transients, transsarcolemmal Ca2+ fluxes, and contraction in ventricular myocytes. Circ Res 1990 Mar;66(3):622-32

Spitzer KW, Bridge JH, A simple device for rapidly exchanging solution surrounding a single cardiac cell. Am J Physiol 1989 Feb;256(2 Pt 1):C441-7

Burgess MJ, Steinhaus BM, Spitzer KW, Ershler PR, Nonuniform epicardial activation and repolarization properties of in vivo canine pulmonary conus. Circ Res 1988 Feb;62(2):233-46