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Ravi  Ranjan
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Office: SOM 4A100

Ravi Ranjan

Associate Professor of Medicine
Adjunct Associate Professor, Bioengineering
PhD, Biomedical Engineering, Johns Hopkins University
MD, Harvard Medical School

Research

Cardiac Electrophysiology


Current Research

I am interested in cardiac electrophysiology with focus on developing new technology and imaging applications for cardiac electrophysiology, mathmatical modeling of arrhythmias and understanding arrhythmia mechanisms at the tissue, cellular and whole organ level.


Selected Publications

Polejaeva IA, Ranjan R, Davies CJ, Regouski M, Hall J, Olsen AL, Meng Q, Rutigliano HM, Dosdall DJ, Angel NA, Sachse FB, Seidel T, Thomas AJ, Stott R, Panter KE, Lee PM, Van Wettere AJ, Stevens JR, Wang Z, MacLeod RS, Marrouche NF, White KL, Increased Susceptibility to Atrial Fibrillation Secondary to Atrial Fibrosis in Transgenic Goats Expressing Transforming Growth Factor-ß1. J Cardiovasc Electrophysiol 2016 Oct;27(10):1220-1229

Kholmovski EG, Coulombe N, Silvernagel J, Angel N, Parker D, Macleod R, Marrouche N, Ranjan R, Real-Time MRI-Guided Cardiac Cryo-Ablation: A Feasibility Study. J Cardiovasc Electrophysiol 2016 May;27(5):602-8

Rupp AB, Ahmadjee A, Morshedzadeh JH, Ranjan R, Carcinoid Syndrome-Induced Ventricular Tachycardia. Case Rep Cardiol 2016;2016:9142598

Parmar BR, Jarrett TR, Kholmovski EG, Hu N, Parker D, MacLeod RS, Marrouche NF, Ranjan R, Poor scar formation after ablation is associated with atrial fibrillation recurrence. J Interv Card Electrophysiol 2015 Dec;44(3):247-56

Angel N, Li LI, Macleod RS, Marrouche N, Ranjan R, Dosdall DJ, Diverse Fibrosis Architecture and Premature Stimulation Facilitate Initiation of Reentrant Activity Following Chronic Atrial Fibrillation. J Cardiovasc Electrophysiol 2015 Dec;26(12):1352-60

Ranjan R, McGann CJ, Jeong EK, Hong K, Kholmovski EG, Blauer J, Wilson BD, Marrouche NF, Kim D, Wideband late gadolinium enhanced magnetic resonance imaging for imaging myocardial scar without image artefacts induced by implantable cardioverter-defibrillator: a feasibility study at 3 T. Europace 2015 Mar;17(3):483-8

Navaravong L, Barakat M, Burgon N, Mahnkopf C, Koopmann M, Ranjan R, Kholmovski E, Marrouche N, Akoum N, Improvement in estimated glomerular filtration rate in patients with chronic kidney disease undergoing catheter ablation for atrial fibrillation. J Cardiovasc Electrophysiol 2015 Jan;26(1):21-7

Pacchia CF, Dosdall DJ, Ranjan R, DiBella E, Alterations in atrial perfusion during atrial fibrillation. Exp Physiol 2014 Oct;99(10):1267-72

Zenger B, Cates J, Morris A, Kholmovski E, Au A, Ranjan R, Akoum N, McGann C, Wilson B, Marrouche N, Han FT, MacLeod RS, A Practical Algorithm for Improving Localization and Quantification of Left Ventricular Scar. Comput Cardiol (2010) 2014 Sep 7;2014:105-108

Blauer JJ, Han F, Ranjan R, Marrouche NF, MacLeod RS, Controlled Activation for Interrogation of the Electrophysiological Substrate. Comput Cardiol (2010) 2014 Sep 9;2014:189-192

Blauer JJ, Swenson D, Higuchi K, Plank G, Ranjan R, Marrouche N, Macleod RS, Sensitivity and specificity of substrate mapping: an in silico framework for the evaluation of electroanatomical substrate mapping strategies. J Cardiovasc Electrophysiol 2014 Jul;25(7):774-80

Parmar BR, Jarrett TR, Burgon NS, Kholmovski EG, Akoum NW, Hu N, Macleod RS, Marrouche NF, Ranjan R, Comparison of left atrial area marked ablated in electroanatomical maps with scar in MRI. J Cardiovasc Electrophysiol 2014 May;25(5):457-63

Ranjan R, Dosdall D, Norlund L, Higuchi K, Silvernagel JM, Olsen AL, Davies CJ, MacLeod R, Marrouche NF, Diagnostic imaging and pacemaker implantation in a domestic goat with persistent left cranial vena cava. J Vet Cardiol 2014 Mar;16(1):45-50

McGann C, Akoum N, Patel A, Kholmovski E, Revelo P, Damal K, Wilson B, Cates J, Harrison A, Ranjan R, Burgon NS, Greene T, Kim D, Dibella EV, Parker D, Macleod RS, Marrouche NF, Atrial fibrillation ablation outcome is predicted by left atrial remodeling on MRI. Circ Arrhythm Electrophysiol 2014 Feb;7(1):23-30

Bassett EC, Kholmovski EG, Wilson BD, DiBella EV, Dosdall DJ, Ranjan R, McGann CJ, Kim D, Evaluation of highly accelerated real-time cardiac cine MRI in tachycardia. NMR Biomed 2014 Feb;27(2):175-82

Fitts M, Breton E, Kholmovski EG, Dosdall DJ, Vijayakumar S, Hong KP, Ranjan R, Marrouche NF, Axel L, Kim D, Arrhythmia insensitive rapid cardiac T1 mapping pulse sequence. Magn Reson Med 2013 Nov;70(5):1274-82

Dosdall DJ, Ranjan R, Higuchi K, Kholmovski E, Angel N, Li L, Macleod R, Norlund L, Olsen A, Davies CJ, Marrouche NF, Chronic atrial fibrillation causes left ventricular dysfunction in dogs but not goats: experience with dogs, goats, and pigs. Am J Physiol Heart Circ Physiol 2013 Sep 1;305(5):H725-31

Higuchi K, Akkaya M, Koopmann M, Blauer JJ, Burgon NS, Damal K, Ranjan R, Kholmovski E, Macleod RS, Marrouche NF, The effect of fat pad modification during ablation of atrial fibrillation: late gadolinium enhancement MRI analysis. Pacing Clin Electrophysiol 2013 Apr;36(4):467-76

Meng Q, Hall J, Rutigliano H, Zhou X, Sessions BR, Stott R, Panter K, Davies CJ, Ranjan R, Dosdall D, Macleod R, Marrouche N, White KL, Wang Z, Polejaeva IA, 30 GENERATION OF CLONED TRANSGENIC GOATS WITH CARDIAC SPECIFIC OVEREXPRESSION OF TRANSFORMING GROWTH FACTOR ß1. Reprod Fertil Dev 2012 Dec;25(1):162-3

Ranjan R, Kholmovski EG, Blauer J, Vijayakumar S, Volland NA, Salama ME, Parker DL, MacLeod R, Marrouche NF, Identification and acute targeting of gaps in atrial ablation lesion sets using a real-time magnetic resonance imaging system. Circ Arrhythm Electrophysiol 2012 Dec;5(6):1130-5

Ranjan R, Magnetic resonance imaging in clinical cardiac electrophysiology. Crit Rev Biomed Eng 2012;40(5):409-26

Akoum N, McGann C, Vergara G, Badger T, Ranjan R, Mahnkopf C, Kholmovski E, Macleod R, Marrouche N, Atrial fibrosis quantified using late gadolinium enhancement MRI is associated with sinus node dysfunction requiring pacemaker implant. J Cardiovasc Electrophysiol 2012 Jan;23(1):44-50

Ranjan R, Kato R, Zviman MM, Dickfeld TM, Roguin A, Berger RD, Tomaselli GF, Halperin HR, Gaps in the ablation line as a potential cause of recovery from electrical isolation and their visualization using MRI. Circ Arrhythm Electrophysiol 2011 Jun;4(3):279-86

Ranjan R, Henrikson CA, ICD implantation after crossing a totally occluded subclavian vein via collaterals from the superior vena cava. Pacing Clin Electrophysiol 2010 Feb;33(2):e14-6

Yannopoulos D, Zviman M, Castro V, Kolandaivelu A, Ranjan R, Wilson RF, Halperin HR, Intra-cardiopulmonary resuscitation hypothermia with and without volume loading in an ischemic model of cardiac arrest. Circulation 2009 Oct 6;120(14):1426-35

Yannopoulos D, Kolandaivelu A, Ranjan R, Flow or no flow: that is the question! Crit Care Med 2008 May;36(5):1677-8

Ranjan R, Tomaselli GF, Marbán E, A novel mechanism of anode-break stimulation predicted by bidomain modeling. Circ Res 1999 Feb 5;84(2):153-6

Ranjan R, Chiamvimonvat N, Thakor NV, Tomaselli GF, Marban E, Mechanism of anode break stimulation in the heart. Biophys J 1998 Apr;74(4):1850-63

Bénitah JP, Ranjan R, Yamagishi T, Janecki M, Tomaselli GF, Marban E, Molecular motions within the pore of voltage-dependent sodium channels. Biophys J 1997 Aug;73(2):603-13

Baykal A, Ranjan R, Thakor NV, Estimation of the ventricular fibrillation duration by autoregressive modeling. IEEE Trans Biomed Eng 1997 May;44(5):349-56

Pérez-García MT, Chiamvimonvat N, Ranjan R, Balser JR, Tomaselli GF, Marban E, Mechanisms of sodium/calcium selectivity in sodium channels probed by cysteine mutagenesis and sulfhydryl modification. Biophys J 1997 Mar;72(3):989-96

Thakor NV, Ranjan R, Rajasekhar S, Mower MM, Effect of varying pacing waveform shapes on propagation and hemodynamics in the rabbit heart. Am J Cardiol 1997 Mar 20;79(6A):36-43

Chiamvimonvat N, Pérez-García MT, Ranjan R, Marban E, Tomaselli GF, Depth asymmetries of the pore-lining segments of the Na+ channel revealed by cysteine mutagenesis. Neuron 1996 May;16(5):1037-47

Ranjan R, Thakor NV, Electrical stimulation of cardiac myocytes. Ann Biomed Eng 1995 Nov-Dec;23(6):812-21

Baykal A, Ranjan R, Thakor NV, Model-based analysis of the ECG during early stages of ventricular fibrillation. J Electrocardiol 1994;27 Suppl:84-90