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Talmage  Egan
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Talmage Egan

Selected Publications

Kim TK, Obara S, Egan TD, Minto CF, LaColla L, Drover DR, Vuyk J, Mertens M, Disposition of Remifentanil in Obesity: A New Pharmacokinetic Model Incorporating the Influence of Body Mass. Anesthesiology 2017 Jun;126(6):1019-1032

Kim TK, Niklewski PJ, Martin JF, Obara S, Egan TD, Enhancing a sedation score to include truly noxious stimulation: the Extended Observer's Assessment of Alertness and Sedation (EOAA/S). Br J Anaesth 2015 Oct;115(4):569-77

Sear JW, Egan TD, David (Propofol Wannabes) Versus Goliath (Propofol): AZD-3043 Goes Up Against the Giant! Anesth Analg 2015 Oct;121(4):849-51

Egan TD, Total intravenous anesthesia versus inhalation anesthesia: a drug delivery perspective. J Cardiothorac Vasc Anesth 2015 Jun;29 Suppl 1:S3-6

Egan TD, Update on total intravenous anesthesia with special emphasis on cardiovascular anesthesia. J Cardiothorac Vasc Anesth 2015 Jun;29 Suppl 1:S1-2

Soto R, Jahr JS, Pavlin J, Sabo D, Philip BK, Egan TD, Rowe E, de Bie J, Woo T, Safety and Efficacy of Rocuronium With Sugammadex Reversal Versus Succinylcholine in Outpatient Surgery-A Multicenter, Randomized, Safety Assessor-Blinded Trial. Am J Ther 2016 Nov/Dec;23(6):e1654-e1662

Yu L, Ting CK, Hill BE, Orr JA, Brewer LM, Johnson KB, Egan TD, Westenskow DR, Using the Entropy of Tracheal Sounds to Detect Apnea during Sedation in Healthy Nonobese Volunteers. Anesthesiology 2013 Jun;118(6):1341-1349

Hanrahan SJ, Greger B, Parker RA, Ogura T, Obara S, Egan TD, House PA, The effects of propofol on local field potential spectra, action potential firing rate, and their temporal relationship in humans and felines. Front Hum Neurosci 2013;7:136

Syroid N, Liu D, Albert R, Agutter J, Egan TD, Pace NL, Johnson KB, Dowdle MR, Pulsipher D, Westenskow DR, Graphical user interface simplifies infusion pump programming and enhances the ability to detect pump-related faults. Anesth Analg 2012 Nov;115(5):1087-97

LaPierre CD, Johnson KB, Randall BR, Egan TD, A simulation study of common propofol and propofol-opioid dosing regimens for upper endoscopy: implications on the time course of recovery. Anesthesiology 2012 Aug;117(2):252-62

Egan TD, Obara S, Jenkins TE, Jaw-Tsai SS, Amagasu S, Cook DR, Steffensen SC, Beattie DT, AZD-3043: a novel, metabolically labile sedative-hypnotic agent with rapid and predictable emergence from hypnosis. Anesthesiology 2012 Jun;116(6):1267-77

Wallentine CB, Shimode N, Egan TD, Pace NL, Propofol in a modified cyclodextrin formulation: first human study of dose-response with emphasis on injection pain. Anesth Analg 2011 Oct;113(4):738-41

LaPierre CD, Johnson KB, Randall BR, White JL, Egan TD, An exploration of remifentanil-propofol combinations that lead to a loss of response to esophageal instrumentation, a loss of responsiveness, and/or onset of intolerable ventilatory depression. Anesth Analg 2011 Sep;113(3):490-9

Syroid ND, Johnson KB, Pace NL, Westenskow DR, Tyler D, Brühschwein F, Albert RW, Roalstad S, Costy-Bennett S, Egan TD, Response surface model predictions of emergence and response to pain in the recovery room: An evaluation of patients emerging from an isoflurane and fentanyl anesthetic. Anesth Analg 2010 Aug;111(2):380-6

Johnson KB, Syroid ND, Gupta DK, Manyam SC, Pace NL, LaPierre CD, Egan TD, White JL, Tyler D, Westenskow DR, An evaluation of remifentanil-sevoflurane response surface models in patients emerging from anesthesia: model improvement using effect-site sevoflurane concentrations. Anesth Analg 2010 Aug;111(2):387-94

Sakata DJ, Matsubara I, Gopalakrishnan NA, Westenskow DR, White JL, Yamamori S, Egan TD, Pace NL, Flow-through versus sidestream capnometry for detection of end tidal carbon dioxide in the sedated patient. J Clin Monit Comput 2009 Apr;23(2):115-22

Johnson KB, Syroid ND, Gupta DK, Manyam SC, Egan TD, Huntington J, White JL, Tyler D, Westenskow DR, An evaluation of remifentanil propofol response surfaces for loss of responsiveness, loss of response to surrogates of painful stimuli and laryngoscopy in patients undergoing elective surgery. Anesth Analg 2008 Feb;106(2):471-9, table of contents

Stanley TH, Egan TD, Van Aken H, A tribute to Dr. Paul A. J. Janssen: entrepreneur extraordinaire, innovative scientist, and significant contributor to anesthesiology. Anesth Analg 2008 Feb;106(2):451-62, table of contents

Manyam SC, Gupta DK, Johnson KB, White JL, Pace NL, Westenskow DR, Egan TD, Opioid-volatile anesthetic synergy: a response surface model with remifentanil and sevoflurane as prototypes. Anesthesiology 2006 Aug;105(2):267-78

Sikharam S, Egan TD, Kern SE, Cyclodextrins as new formulation entities and therapeutic agents. Curr Opin Anaesthesiol 2005 Aug;18(4):392-5

Davis JJ, Swenson JD, Hall RH, Dillon JD, Johnson KB, Egan TD, Pace NL, Niu SY, Preoperative "fentanyl challenge" as a tool to estimate postoperative opioid dosing in chronic opioid-consuming patients. Anesth Analg 2005 Aug;101(2):389-95, table of contents

Richardson SP, Egan TD, The safety of remifentanil by bolus injection. Expert Opin Drug Saf 2005 Jul;4(4):643-51

Johnson KB, Egan TD, Kern SE, McJames SW, Cluff ML, Pace NL, Influence of hemorrhagic shock followed by crystalloid resuscitation on propofol: a pharmacokinetic and pharmacodynamic analysis. Anesthesiology 2004 Sep;101(3):647-59

Kern SE, Xie G, White JL, Egan TD, A response surface analysis of propofol-remifentanil pharmacodynamic interaction in volunteers. Anesthesiology 2004 Jun;100(6):1373-81

Egan TD, Kern SE, Muir KT, White J, Remifentanil by bolus injection: a safety, pharmacokinetic, pharmacodynamic, and age effect investigation in human volunteers. Br J Anaesth 2004 Mar;92(3):335-43

Davis JJ, Johnson KB, Egan TD, Vezina DP, Snell TE, Swenson JD, Preoperative fentanyl infusion with pharmacokinetic simulation for anesthetic and perioperative management of an opioid-tolerant patient. Anesth Analg 2003 Dec;97(6):1661-2

Egan TD, Target-controlled drug delivery: progress toward an intravenous "vaporizer" and automated anesthetic administration. Anesthesiology 2003 Nov;99(5):1214-9

Lee M, Kern SE, Kisicki JC, Egan TD, A pharmacokinetic study to compare two simultaneous 400 microg doses with a single 800 microg dose of oral transmucosal fentanyl citrate. J Pain Symptom Manage 2003 Aug;26(2):743-7

Johnson KB, Egan TD, Kern SE, White JL, McJames SW, Syroid N, Whiddon D, Church T, The influence of hemorrhagic shock on propofol: a pharmacokinetic and pharmacodynamic analysis. Anesthesiology 2003 Aug;99(2):409-20

Egan TD, Kern SE, Johnson KB, Pace NL, The pharmacokinetics and pharmacodynamics of propofol in a modified cyclodextrin formulation (Captisol) versus propofol in a lipid formulation (Diprivan): an electroencephalographic and hemodynamic study in a porcine model. Anesth Analg 2003 Jul;97(1):72-9, table of contents

Johnson KB, Egan TD, Layman J, Kern SE, White JL, McJames SW, The influence of hemorrhagic shock on etomidate: a pharmacokinetic and pharmacodynamic analysis. Anesth Analg 2003 May;96(5):1360-8, table of contents

Johnson KB, Swenson JD, Egan TD, Jarrett R, Johnson M, Midazolam and remifentanil by bolus injection for intensely stimulating procedures of brief duration: experience with awake laryngoscopy. Anesth Analg 2002 May;94(5):1241-3, table of contents

Johnson KB, Kern SE, Hamber EA, McJames SW, Kohnstamm KM, Egan TD, Influence of hemorrhagic shock on remifentanil: a pharmacokinetic and pharmacodynamic analysis. Anesthesiology 2001 Feb;94(2):322-32

Egan TD, Pharmacokinetics and pharmacodynamics of remifentanil: an update in the year 2000. Curr Opin Anaesthesiol 2000 Aug;13(4):449-55

Miner JE, Egan TD, An AIDS-associated cause of the difficult airway: supraglottic Kaposi's sarcoma. Anesth Analg 2000 May;90(5):1223-6

Egan TD, Sharma A, Ashburn MA, Kievit J, Pace NL, Streisand JB, Multiple dose pharmacokinetics of oral transmucosal fentanyl citrate in healthy volunteers. Anesthesiology 2000 Mar;92(3):665-73

Farnsworth ST, Egan TD, Johnson SE, Westenskow D, Teaching sedation and analgesia with simulation. J Clin Monit Comput 2000;16(4):273-85

Manullang J, Egan TD, Remifentanil's effect is not prolonged in a patient with pseudocholinesterase deficiency. Anesth Analg 1999 Aug;89(2):529-30

Egan TD, Kuramkote S, Gong G, Zhang J, McJames SW, Bailey PL, Fentanyl pharmacokinetics in hemorrhagic shock: a porcine model. Anesthesiology 1999 Jul;91(1):156-66

Reusche MD, Egan TD, Remifentanil for conscious sedation and analgesia during awake fiberoptic tracheal intubation: a case report with pharmacokinetic simulations. J Clin Anesth 1999 Feb;11(1):64-8

Smyth E, Egan TD, Apneic oxygenation associated with patient-controlled analgesia. J Clin Anesth 1998 Sep;10(6):499-501

Egan TD, Huizinga B, Gupta SK, Jaarsma RL, Sperry RJ, Yee JB, Muir KT, Remifentanil pharmacokinetics in obese versus lean patients. Anesthesiology 1998 Sep;89(3):562-73

Brada SA, Egan TD, Viscomi CM, The use of remifentanil infusion to facilitate epidural catheter placement in a parturient: a case report with pharmacokinetic simulations. Int J Obstet Anesth 1998 Apr;7(2):124-7

Streisand JB, Busch MA, Egan TD, Smith BG, Gay M, Pace NL, Dose proportionality and pharmacokinetics of oral transmucosal fentanyl citrate. Anesthesiology 1998 Feb;88(2):305-9

Johnson KB, Egan TD, Remifentanil and propofol combination for awake craniotomy: case report with pharmacokinetic simulations. J Neurosurg Anesthesiol 1998 Jan;10(1):25-9

Egan TD, Intravenous drug delivery systems: toward an intravenous "vaporizer". J Clin Anesth 1996 May;8(3 Suppl):8S-14S

Egan TD, Minto CF, Hermann DJ, Barr J, Muir KT, Shafer SL, Remifentanil versus alfentanil: comparative pharmacokinetics and pharmacodynamics in healthy adult male volunteers. Anesthesiology 1996 Apr;84(4):821-33

Egan TD, Remifentanil pharmacokinetics and pharmacodynamics. A preliminary appraisal. Clin Pharmacokinet 1995 Aug;29(2):80-94

Egan TD, Lemmens HJ, Fiset P, Hermann DJ, Muir KT, Stanski DR, Shafer SL, The pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers. Anesthesiology 1993 Nov;79(5):881-92

Egan TD, Wong KC, Predicting difficult laryngoscopy for tracheal intubation: an approach to airway assessment. Ma Zui Xue Za Zhi 1993 Sep;31(3):165-78

Egan TD, Joyce SM, Acute compartment syndrome following a minor athletic injury. J Emerg Med 1989 Jul-Aug;7(4):353-7