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Friday March 2, 2018 -- Massively Parallel All-Optical Cardiac Electrophysiology

SMBB 2650, 11:45 am

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Speaker: Emilia Entcheva, Professor, Biomedical Engineering, George Washington University

Presentation Abstract:

Optical targeting (stimulation or recording) allows distributed parallel access to thousands and even millions of cells and locations at the same time, and within the tissue setting; optical targeting is high-throughput by nature. In this talk, I will discuss and demonstrate the combination of optogenetic stimulation with optical imaging of electrical activity in cardiomyocytes, i.e. the realization of “all-optical electrophysiology” in a high-throughput manner (HTS). Examples will include demonstration of cardiac “wave steering” by light and the use of a new fully-automated all-optical HTS platform (OptoDyCE) for drug screening using patient-derived cardiomyocytes (iPS-CMs).

Faculty Host: Frank Sachse Contact: