Student Presentation -- Mark Elliott
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M.S. Thesis Defense, Thursday May 10, 2018 -- Establishment of an Automated Algorithm Utilizing Optical Coherence Tomography and Micro-Computed Tomography Imaging to Reconstruct the 3D Deformed Stent Geometry

WEB 3780 Evans conference room, 9:00 am

Speaker: Mark Elliott. Advisor: Dr. Luke Timmins


Percutaneous coronary intervention (PCI) is the prevalent treatment for coronary artery disease, with hundreds of thousands of stents implanted annually. Computational studies have demonstrated the role of biomechanics in the failure of vascular stents, but these studies are limited by a lack of understanding of the deployed stent geometry, which is required to accurately model and predict the stent-induced in vivo biomechanical environment. Herein, we present an automated method to reconstruct the 3D deployed stent configuration through the fusion of optical coherence tomography (OCT) and micro-computed tomography (uCT) imaging data. In an experimental setup, OCT and uCT data were collected in stents deployed in arterial phantoms (n = 4). A constrained iterative deformation process directed by diffeomorphic metric mapping was developed to deform uCT data of a stent wireframe to the OCT-derived sparse point cloud of the deployed stent. Reconstructions of the deployed stent showed excellent agreement with the ground truth configuration, with corresponding points between the reconstructed and ground truth configurations of 184 +/- 96 um. Furthermore, approximately 85% of the corresponding points were within 90 um, which is the approximate width of the stent designs investigated, of the ground truth geometry. Finally, reconstructions required < 30 minutes of computational time. In conclusion, the developed and validated reconstruction algorithm provides a complete spatially resolved reconstruction of a deployed vascular stent that will allow more accurate computational models to evaluate the in vivo post-stent mechanical environment, as well as clinical visualization of the stent geometry immediately following PCI.